Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Clinical Results of Drug-Coated Balloon Treatment in a Large-Scale Multicenter Korean Registry Study

  • Sang Yeub Lee (Division of Cardiology, Chung-Ang University Gwangmyeong Hospital and Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Yun-Kyeong Cho (Department of Cardiology, Keimyung University Dongsan Hospital) ;
  • Sang-Wook Kim (Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine) ;
  • Young-Joon Hong (Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University College of Medicine) ;
  • Bon-Kwon Koo (Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Jang-Whan Bae (Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine) ;
  • Seung-Hwan Lee (Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University, Wonju College of Medicine) ;
  • Tae Hyun Yang (Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Hun Sik Park (Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine) ;
  • Si Wan Choi (Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine) ;
  • Do-Sun Lim (Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine) ;
  • Soo-Joong Kim (Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine) ;
  • Young Hoon Jeong (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Hyun-Jong Lee (Bucheon Sejong Hospital) ;
  • Kwan Yong Lee (Incheon Saint Mary's Hospital) ;
  • Eun-Seok Shin (Department of Internal Medicine, Ulsan University Hospital, Ulsan University College of Medicine) ;
  • Ung Kim (Department of Internal Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine) ;
  • Moo Hyun Kim (Department of Internal Medicine, Dong-A University Hospital, Dong-A University College of Medicine) ;
  • Chang-Wook Nam (Department of Cardiology, Keimyung University Dongsan Hospital) ;
  • Seung-Ho Hur (Department of Cardiology, Keimyung University Dongsan Hospital) ;
  • Doo-Il Kim (Department of Cardiology, Inje University Haeundae Baek Hospital, Inje University College of Medicine) ;
  • Stent Failure Research Group (SFR) Drug coated balloon (DCB) registry investigators (Stent Failure Research Group (SFR))
  • Received : 2021.07.30
  • Accepted : 2022.02.23
  • Published : 2022.06.01
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Abstract

Background and Objectives: The aim of this study was to demonstrate the efficacy and safety of treatment with drug-coated balloon (DCB) in a large real-world population. Methods: Patients treated with DCBs were included in a multicenter observational registry that enrolled patients from 18 hospitals in Korea between January 2009 and December 2017. The primary outcome was target lesion failure (TLF) defined as a composite of cardiovascular death, target vessel myocardial infarction, and clinically indicated target lesion revascularization at 12 months. Results: The study included 2,509 patients with 2,666 DCB-treated coronary artery lesions (1,688 [63.3%] with in-stent restenosis [ISR] lesions vs. 978 [36.7%] with de novo lesions). The mean age with standard deviation was 65.7±11.3 years; 65.7% of the patients were men. At 12 months, the primary outcome, TLF, occurred in 179 (6.7%), 151 (8.9%), 28 (2.9%) patients among the total, ISR, and de novo lesion populations, respectively. A history of hypertension, diabetes, acute coronary syndrome, previous coronary artery bypass graft, reduced left ventricular ejection fraction, B2C lesion and ISR lesion were independent predictors of 12 months TLF in the overall study population. Conclusions: This large multicenter DCB registry study revealed the favorable clinical outcome of DCB treatment in real-world practice in patient with ISR lesion as well as small de novo coronary lesion.

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References

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