Korean Circulation Journal

  • 제52권3호
  • /
  • Pages.220-230
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  • 2022
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study

  • Jung-Ho Yang (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Ji-An Jeong (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Sun-Seog Kweon (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Young-Hoon Lee (Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine) ;
  • Seong-Woo Choi (Department of Preventive Medicine, Chosun University Medical School) ;
  • So-Yeon Ryu (Department of Preventive Medicine, Chosun University Medical School) ;
  • Hae-Sung Nam (Department of Preventive Medicine, Chungnam National University Medical School) ;
  • Kyeong-Soo Park (Cardiocerebrovascular Center, Mokpo Jung-Ang Hospital) ;
  • Hye-Yeon Kim (Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital) ;
  • Min-Ho Shin (Department of Preventive Medicine, Chonnam National University Medical School)
  • 투고 : 2021.08.10
  • 심사 : 2021.11.30
  • 발행 : 2022.03.01
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초록

Background and Objectives: Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is the genetic variant with the most potent effect on drinking behavior. Methods: A total of 8,964 participants from the Dong-gu Study were included in the present study. The causal association between alcohol consumption and AF was evaluated through a Mendelian randomization (MR) analysis using the ALDH2 rs671 polymorphism as an instrumental variable. Results: No significant relationship between alcohol consumption and AF was found in the observational analysis. However, the genetic analysis using the ALDH2 polymorphism showed a significant association in men. In the MR analysis, genetically predicted daily alcohol consumption was positively related to AF. Conclusions: MR analysis revealed a significant association between the amount of alcohol consumption and AF, which suggests that the association may be causal.

키워드

과제정보

This study was supported by a grant (BCRI 21062) Chonnam National University Hospital Biomedical Research Institute.

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