DOI QR코드

DOI QR Code

A Study on the Exposure Factors Used in the Assessment of Inhalation Exposure to Household Chemicals

생활화학제품의 흡입노출평가에 사용되는 노출계수에 대한 고찰

  • Yoon, Chungsik (Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University) ;
  • Kwon, Taehong (Institute of Health and Environment, Seoul National University) ;
  • Oh, Gitaek (Institute of Health and Environment, Seoul National University) ;
  • Kim, Minjung (Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University) ;
  • Kim, Boowook (Institute of Health and Environment, Seoul National University) ;
  • Shin, CheolWoong (Air Environment Center, Korea Conformity Laboratories) ;
  • Lee, Kiyoung (Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University) ;
  • Zoh, Kyungduk (Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University)
  • 윤충식 (서울대학교 보건대학원 환경보건학과) ;
  • 권태홍 (서울대학교 보건환경연구소) ;
  • 오기택 (서울대학교 보건환경연구소) ;
  • 김민정 (서울대학교 보건대학원 환경보건학과) ;
  • 김부욱 (서울대학교 보건환경연구소) ;
  • 신철웅 ((재)한국건설생활환경시험연구원 공기환경센터) ;
  • 이기영 (서울대학교 보건대학원 환경보건학과) ;
  • 조경덕 (서울대학교 보건대학원 환경보건학과)
  • Received : 2022.07.07
  • Accepted : 2022.08.20
  • Published : 2022.08.31

Abstract

Background: The biggest concern when using household chemical products is the health risk from inhalation exposure. Objectives: The purpose of this paper was to provide information necessary for estimating inhalation exposure factors in several countries/organizations and to present some examples. Methods: We attempted to use PRISMA-ScR for a systematic review, but no major reports were found. We used the Google search function instead to find 'exposure factor handbook'. As for the results, inhalation exposure factors from South Korea, the United States, Canada, the EU, Australia, Japan, and China were compared. Results: The basic concept and origin of exposure factors was the US Environmental Protection Agency's Exposure Factor Handbook. Its latest version is 2011, but several chapters have been updated in 2017, 2018, and 2019. South Korea's Exposure Factor Handbook was updated in 2019, more recently than those of other countries, and was systematically investigated. In South Korea, the average daily respiratory rate is 14.62 m3/day for adults and 12.73 m3/day for children. It is difficult to compare breathing rate by country because each country divides age groups differently and uses different methods to estimate it. Information on household chemical products, space used, and ventilation rate are in the exposure factor handbook in some countries and not in others. It is not in the handbook in South Korea, but in the notice from the NIER (National Institute of Environmental Research), a sub-regulation of the Chemical Product Safety Act. Conclusions: The exposure factors registered in South Korea's exposure factor handbook have been systematically studied and reflect the most recent data. When using data not in the relevant handbook, data from other countries might be applied, but it should be determined whether the nature and quality of the original data have been managed.

Keywords

Acknowledgement

본 결과물은 환경부의 재원으로 한국환경산업기술원의 생활화학제품 안전관리 기술개발사업(2021002970003, 1485017937)과 한국연구재단(BK21 FOUR 5199990214126)의 지원을 받아 연구되었다.

References

  1. Park JH, Yoon CS. Model algorithms for estimates of inhalation exposure and comparison between exposure estimates from each model. J Korean Soc Occup Environ Hyg. 2019; 29(3): 358-367.
  2. U.S. Environmental Protection Agency. Exposure Factors Handbook. Available: http://rais.ornl.gov/documents/EFH_1989_EPA600889043.pdf [accessed 21 June 2022].
  3. U.S. Environmental Protection Agency. Methods for Assessing Exposure to Chemical Substances: Volume 7. Washington, DC: U.S. Environmental Protection Agency; 1987.
  4. U.S. Environmental Protection Agency. Standard Scenarios for Estimating Exposure to Chemical Substances during Use of Consumer Products: Volume I. Washington, DC: U.S. Environmental Protection Agency; 1986.
  5. U.S. Environmental Protection Agency. Standard Scenarios for Estimating Exposure to Chemical Substances during Use of Consumer Products: Volume II. Washington, DC: U.S. Environmental Protection Agency; 1986.
  6. Jang JY, Jo SN, Kim SY, Kim SJ, Cheong HK. Korean Exposure Factors Handbook. Seoul: Ministry of Environment; 2007.
  7. Seo JK, Yoon HJ, Kim T, Kim JH, Joe AR, Lee BW, et al. Korean Exposure Factors Handbook for Children. Incheon: National Institute of Environmental Research; 2016.
  8. National Institute of Environmental Research. Korean Exposure Factors Handbook for children. Incheon: National Institute of Environmental Research; 2019.
  9. National Institute of Environmental Research. Korean Exposure Factors Handbook. Incheon: National Institute of Environmental Research; 2019.
  10. Yoon H, Seo J, Yoo SK, Kim PJ, Park J, Choe Y, et al. Updated general exposure factors for risk assessment in the Korean population. J Expo Sci Environ Epidemiol. 2022. https://doi.org/10.1038/s41370-022-00437-6.
  11. Ministry of Environment. Act on Registration, Evaluation, etc. of Chemicals. Sejong: Ministry of Environment; 2015.
  12. Ministry of Environment. Act on the Safety Management of Living Chemicals and Biocide. Sejong: Ministry of Environment; 2019.
  13. Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018; 169(7): 467-473. https://doi.org/10.7326/M18-0850
  14. RIVM. General Fact Sheet, Children's Toys Fact Sheet, Cleaning Products Fact Sheet, Cosmetics Fact Sheet, Disinfectant Products Fact Sheet, Do-It-Yourself Products Fact Sheet, Paint Products Fact Sheet, Pest Control Products Fact Sheet. Available: https://www.rivm.nl/en/consexpo/fact-sheets [accessed 2 August 2022].
  15. Government of Canada. Canadian Exposure Factors used in Human Health Risk Assessments 2022 Modified. Available: https://www.canada.ca/en/health-canada/services/chemical-substances/fact-sheets/canadian-exposure-factors-human-health-risk-assessments.html [accessed 21 June 2022].
  16. Health Canada-Pest Management Regulatory Agency. General Exposure Factor Inputs for Dietary, Occupational, and Residential Exposure Assessments. Available: https://www.canada.ca/en/health-canada/services/consumer-product-safety/reports-publications/pesticides-pest-management/policies-guidelines/science-policy-notes/2014/general-exposure-factor-inputs-dietary-occupational-residential-exposure-assessments-spn2014-01.html [accessed 21 June 2022].
  17. Duan X, Zhao X, Wang B, Chen Y, Cao S. Highlights of the Chinese Exposure Factors Handbook (Adults). Beijing: Science Press; 2015.
  18. Gamo M, Futatsumata M. Development of Japanese exposure factors handbook. Epidemiology. 2006; 17(6): S528-S529. https://doi.org/10.1097/00001648-200611001-01423
  19. U.S. Environmental Protection Agency. Exposure Factors Handbook 2011. Available: https://cfpub.epa.gov/si/si_public_record_report.cfm?Lab=NCEA&dirEntryId=236252#:~:text=EPA%announced%the%release%of%the%final%report%2C,the%various%human%factors%used%in%assessing%exposure [accessed 21 June 2022].
  20. World Health Organization. Uncertainty and Data Quality in Exposure Assessment. Geneva: World Health Organization; 2009.
  21. U.S. Environmental Protection Agency. Guidelines for Exposure Assessment. Available: https://www.epa.gov/sites/default/files/2014-11/documents/guidelines_exp_assessment.pdf [accessed 21 June 2022].
  22. U.S. Environmental Protection Agency. Guidance on Selecting Age Groups for Monitoring and Assessing Childhood Exposures to Environmental Contaminants. Available: https://www.epa.gov/sites/default/files/2013-09/documents/agegroups.pdf [accessed 21 June 2022].
  23. U.S. Environmental Protection Agency. Child-specific Exposure Factors Handbook. Available: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=199243 [accessed 21 June 2022].
  24. Phillips LJ, Moya J. Exposure factors resources: contrasting EPA's exposure factors handbook with international sources. J Expo Sci Environ Epidemiol. 2014; 24(3): 233-243. https://doi.org/10.1038/jes.2013.17
  25. Government of Canada. CEPA, Topics in Risk Assessment of Substances under the Canadian Environmental Protection Act. Ottawa: Government of Canada; 1999.
  26. enHealth Steering Committee. The Australian Exposure Factor Guidance Handbook. Available: https://www.health.vic.gov.au/publications/the-australian-exposure-factor-guidance-handbook [accessed 21 June 2022].
  27. Duan X, Zhao X, Wang B, Zhao L, Cheng H, Cao S. Highlights of the Chinese Exposure Factors Handbook (Children). Beijing: China Environmental Science Press; 2016.
  28. Kawahara J, Tanaka S, Tanaka C, Aoki Y, Yonemoto J. Daily inhalation rate and time-activity/location pattern in Japanese preschool children. Risk Anal. 2012; 32(9): 1595-1604. https://doi.org/10.1111/j.1539-6924.2011.01776.x
  29. Rusconi F, Castagneto M, Gagliardi L, Leo G, Pellegatta A, Porta N, et al. Reference values for respiratory rate in the first 3 years of life. Pediatrics. 1994; 94(3): 350-355. https://doi.org/10.1542/peds.94.3.350
  30. European Commission. Guidance on Information Requirements and Chemical Safety Assessment Chapter R.15: Consumer Exposure Estimation. Available: https://echa.europa.eu/documents/10162/23047722/r15_update_version_2_rev20_en.pdf/ea08eca8-c0f9-41a0-9a3f-fdab925151b1 [accessed 21 June 2022].
  31. ECETOC. TR 079 - Exposure Factors Sourcebook for European Populations (with Focus on UK Data). Available: https://www.ecetoc.org/publication/tr-079-exposure-factors-sourcebook-for-european-populations-with-focus-on-uk-data/ [accessed 2 August 2022].
  32. Nordic Council of Ministers. Existing Default Values and Recommendations for Exposure Assessment. Copenhagen: Nordic Council of Ministers; 2012.
  33. National Institute of Environmental Research. Regulations on the Subject and Method of Risk Assessment for Household Chemical Products. Incheon: National Institute of Environmental Research; 2018.
  34. National Institute of Environmental Research. A Guideline for the Evaluation of Exposure According to the Use of Biocidal Products - Disinfectants and Exterminants. Incheon: National Institute of Environmental Research; 2021.
  35. U.S. Environmental Protection Agency. Exposure Factors Handbook (1997, Final Report). Available: https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=12464 [accessed 21 June 2022].
  36. Loretz LJ, Api AM, Babcock L, Barraj LM, Burdick J, Cater KC, et al. Exposure data for cosmetic products: facial cleanser, hair conditioner, and eye shadow. Food Chem Toxicol. 2008; 46(5): 1516-1524. https://doi.org/10.1016/j.fct.2007.12.011
  37. Sathyanarayana S, Karr CJ, Lozano P, Brown E, Calafat AM, Liu F, et al. Baby care products: possible sources of infant phthalate exposure. Pediatrics. 2008; 121(2): e260-e268. https://doi.org/10.1542/peds.2006-3766
  38. Zenie A, Reina V. ExpoFacts Database. Available: http://data.europa.eu/89h/jrc-10114-10001 [accessed 21 June 2022].