Clinical Endoscopy

The Korean Society of Gastrointestinal Endoscopy (대한소화기내시경학회)
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Acute Liver Failure Secondary to Hepatic Infiltration of Malignant Melanoma

  • Yujin Lee (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Jaekwang Lee (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Hyunsoo Kim (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Changkeun Park (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Jaekwon Jung (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Daejin Kim (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Yun Jin Chung (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Hanjun Ryu (Department of Internal Medicine, Daegu Fatima Hospital)
  • Received : 2020.10.16
  • Accepted : 2021.01.22
  • Published : 2022.03.30
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Abstract

Acute liver failure due to malignant melanoma is uncommon. We presents a case of acute liver failure secondary to hepatic infiltration of a malignant melanoma. An 86-year-old man was admitted with elevated liver enzymes and an increased lactate dehydrogenase level. His condition progressed to acute liver failure, but the etiology of liver failure was unclear. Esophagogastroduodenoscopy was performed to evaluate dyspepsia, which showed signs indicative of malignant melanoma. Based on the endoscopy findings and elevated liver enzyme levels, liver biopsy was performed to confirm the presence of malignant melanoma. Hepatic infiltration of malignant melanoma was observed histologically. However, massive and diffuse liver metastasis is very rare and difficult to identify on imaging studies. If the etiology of liver failure is unclear, diffuse metastatic melanoma infiltration should be considered as differential diagnosis. Early liver biopsy can help to clarify the diagnosis.

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References

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