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Influence of middle hepatic vein resection during right or left hepatectomy on post hepatectomy outcomes

  • Anisa Nutu (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Michael Wilson (Department of Nuclear Medicine, Queen Elizabeth Hospital) ;
  • Erin Ross (Department of Nuclear Medicine, Queen Elizabeth Hospital) ;
  • Kunal Joshi (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Robert Sutcliffe (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Keith Roberts (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Ravi Marudanayagam (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Paolo Muiesan (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Nikolaos Chatzizacharias (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Darius Mirza (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • John Isaac (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital) ;
  • Bobby V. M. Dasari (Department of Hepato-Biliary and Pancreatic and Liver Transplantation, Queen Elizabeth Hospital)
  • 투고 : 2021.11.18
  • 심사 : 2022.02.04
  • 발행 : 2022.08.31

초록

Backgrounds/Aims: Middle hepatic vein (MHV) is usually preserved as a part of the right or left hepatectomy in order preserve the venous outflow of remnant liver. The aim of this study was to evaluate if resection of MHV could influence post-resection outcomes of standard right or left hepatectomy. Methods: Patients who underwent standard right or left hepatectomy between January 2015 and December 2019 were included. Anatomical remnant liver volumes were measured retrospectively using the Hermes workstation (Hermes Medical Solutions AB, Stockholm, Sweden). Uni- and multi-variate analyses were performed to assess the difference in outcomes of those with preservation of MHV and those without preservation. Results: A total of 144 patients were included. Right hepatectomy was performed for 114 (79.2%) and left hepatectomy was performed for 30 (20.8%) patients. MHV was resected for 13 (9.0%) in addition to the standard right or left hepatectomy. Median remnant liver volume was significantly higher in the MHV resected group (p < 0.01). There was no significant difference in serum level of bilirubin, international normalized ratio, alanine aminotransferase, creatinine on postoperative day 1, 3, 5, or 10, ≥ grade IIIa complications (p = 0.44), or 90-day mortality (p = 0.41). On multivariable analysis, resection of the MHV did not influence the incidence of post hepatectomy liver failure (p = 0.52). Conclusions: Resection of the MHV at standard right or left hepatectomy did not have a negative impact on postoperative outcomes of patients with adequate remnant liver volume.

키워드

과제정보

The Preliminary findings were presented at the 14th Congress of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), 15-17 September 2021, Bibalo. HPB 2021;23(Suppl 3):801.

참고문헌

  1. Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery 2011;149:713-724.
  2. Lee JW, Lee JH, Park Y, Lee W, Kwon J, Song KB, et al. Risk factors of posthepatectomy liver failure for perihilar cholangiocarcinoma: risk score and significance of future liver remnant volume-to-body weight ratio. J Surg Oncol 2020;122:469-479.
  3. Inoue Y, Suzuki Y, Ota M, Fujii K, Kawaguchi N, Shimizu T, et al. Comparison of regeneration of remnant liver after hemihepatectomy with or without the middle hepatic vein. World J Surg 2018;42:1100-1110.
  4. Yu PF, Wu J, Zheng SS. Management of the middle hepatic vein and its tributaries in right lobe living donor liver transplantation. Hepatobiliary Pancreat Dis Int 2007;6:358-363.
  5. Varghese CT, Bharathan VK, Gopalakrishnan U, Balakrishnan D, Menon RN, Sudheer OV, et al. Randomized trial on extended versus modified right lobe grafts in living donor liver transplantation. Liver Transpl 2018;24:888-896.
  6. Vauthey JN, Chaoui A, Do KA, Bilimoria MM, Fenstermacher MJ, Charnsangavej C, et al. Standardized measurement of the future liver remnant prior to extended liver resection: methodology and clinical associations. Surgery 2000;127:512-519.
  7. Urata K, Kawasaki S, Matsunami H, Hashikura Y, Ikegami T, Ishizone S, et al. Calculation of child and adult standard liver volume for liver transplantation. Hepatology 1995;21:1317-1321.
  8. Guglielmi A, Ruzzenente A, Conci S, Valdegamberi A, Iacono C. How much remnant is enough in liver resection? Dig Surg 2012;29:6-17.
  9. Dasari BVM, Wilson M, Pufal K, Kadam P, Hodson J, Roberts KJ, et al. Variations between the anatomical and functional distribution, based on 99m technetium -mebrofinate SPECT-CT scan, in patients at risk of post hepatectomy liver failure. HPB (Oxford) 2021;23:1807-1814.
  10. Bogner A, Reissfelder C, Striebel F, Mehrabi A, Ghamarnejad O, Rahbari M, et al. Intraoperative increase of portal venous pressure is an immediate predictor of posthepatectomy liver failure after major hepatectomy: a prospective study. Ann Surg 2021;274:e10-e17.
  11. Faitot F, Vibert E, Salloum C, Gorden DL, Coscas F, Adam R, et al. Importance of conserving middle hepatic vein distal branches for homogeneous regeneration of the left liver after right hepatectomy. HPB (Oxford) 2012;14:746-753.
  12. Morioka D, Tanaka K, Sekido H, Matsuo K, Sugita M, Ueda M, et al. Disruption of the middle hepatic vein is not crucial for liver regeneration of the remnant liver after right hemihepatectomy for hepatic tumors. Ann Surg Oncol 2006;13:1560-1568.
  13. Scatton O, Plasse M, Dondero F, Vilgrain V, Sauvanet A, Belghiti J. Impact of localized congestion related to venous deprivation after hepatectomy. Surgery 2008;143:483-489.
  14. Sano T, Shimada K, Nara S, Sakamoto Y, Kosuge T. Reconstruction of hepatic venous tributaries using a Y-shaped left portal vein graft harvested from a resected left liver. Hepatogastroenterology 2008;55:228-230.
  15. Mise Y, Hasegawa K, Satou S, Aoki T, Beck Y, Sugawara Y, et al. Venous reconstruction based on virtual liver resection to avoid congestion in the liver remnant. Br J Surg 2011;98:1742-1751.