Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Cellular Senescence: The Villain of Metabolic Disease?

  • Lee, Gung (National Leader Research Initiatives Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University)
  • Received : 2022.05.19
  • Accepted : 2022.05.23
  • Published : 2022.08.31
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Abstract

Keywords

Acknowledgement

This study was supported by the National Research Foundation, funded by the Korea government (NRF-2020R1A3B2078617 and NRF-2021R1I1A1A01060100).

References

  1. Coppe, J.P., Desprez, P.Y., Krtolica, A., and Campisi, J. (2010). The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99-118. https://doi.org/10.1146/annurev-pathol-121808-102144
  2. Gorgoulis, V., Adams, P.D., Alimonti, A., Bennett, D.C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019). Cellular senescence: defining a path forward. Cell 179, 813-827. https://doi.org/10.1016/j.cell.2019.10.005
  3. Hernandez-Segura, A., Nehme, J., and Demaria, M. (2018). Hallmarks of cellular senescence. Trends Cell Biol. 28, 436-453. https://doi.org/10.1016/j.tcb.2018.02.001
  4. Kahn, S.E., Hull, R.L., and Utzschneider, K.M. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846. https://doi.org/10.1038/nature05482
  5. Kim, S. and Kim, C. (2021). Transcriptomic analysis of cellular senescence: one step closer to senescence atlas. Mol. Cells 44, 136-145. https://doi.org/10.14348/molcells.2021.2239
  6. Lee, G., Kim, Y.Y., Jang, H., Han, J.S., Nahmgoong, H., Park, Y.J., Han, S.M., Cho, C., Lim, S., Noh, J.R., et al. (2022). SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity. Cell Metab. 34, 702-718.e5. https://doi.org/10.1016/j.cmet.2022.03.010
  7. Palmer, A.K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M.M., Hachfeld, C.M., Prata, L.G., van Dijk, T.H., Verkade, E., Casaclang-Verzosa, G., et al. (2019). Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell 18, e12950.
  8. Tchkonia, T., Morbeck, D.E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M.D., and Kirkland, J.L. (2010). Fat tissue, aging, and cellular senescence. Aging Cell 9, 667-684. https://doi.org/10.1111/j.1474-9726.2010.00608.x
  9. Wang, B., Wang, L., Gasek, N.S., Zhou, Y., Kim, T., Guo, C., Jellison, E.R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021). An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat. Aging 1, 962-973. https://doi.org/10.1038/s43587-021-00107-6
  10. Wang, L., Wang, B., Gasek, N.S., Zhou, Y., Cohn, R.L., Martin, D.E., Zuo, W., Flynn, W.F., Guo, C., Jellison, E.R., et al. (2022). Targeting p21(Cip1) highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 34, 75-89.e8. https://doi.org/10.1016/j.cmet.2021.11.002