과제정보
This study was supported by the National Research Foundation, funded by the Korea government (NRF-2020R1A3B2078617 and NRF-2021R1I1A1A01060100).
참고문헌
- Coppe, J.P., Desprez, P.Y., Krtolica, A., and Campisi, J. (2010). The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99-118. https://doi.org/10.1146/annurev-pathol-121808-102144
- Gorgoulis, V., Adams, P.D., Alimonti, A., Bennett, D.C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019). Cellular senescence: defining a path forward. Cell 179, 813-827. https://doi.org/10.1016/j.cell.2019.10.005
- Hernandez-Segura, A., Nehme, J., and Demaria, M. (2018). Hallmarks of cellular senescence. Trends Cell Biol. 28, 436-453. https://doi.org/10.1016/j.tcb.2018.02.001
- Kahn, S.E., Hull, R.L., and Utzschneider, K.M. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846. https://doi.org/10.1038/nature05482
- Kim, S. and Kim, C. (2021). Transcriptomic analysis of cellular senescence: one step closer to senescence atlas. Mol. Cells 44, 136-145. https://doi.org/10.14348/molcells.2021.2239
- Lee, G., Kim, Y.Y., Jang, H., Han, J.S., Nahmgoong, H., Park, Y.J., Han, S.M., Cho, C., Lim, S., Noh, J.R., et al. (2022). SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity. Cell Metab. 34, 702-718.e5. https://doi.org/10.1016/j.cmet.2022.03.010
- Palmer, A.K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M.M., Hachfeld, C.M., Prata, L.G., van Dijk, T.H., Verkade, E., Casaclang-Verzosa, G., et al. (2019). Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell 18, e12950.
- Tchkonia, T., Morbeck, D.E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M.D., and Kirkland, J.L. (2010). Fat tissue, aging, and cellular senescence. Aging Cell 9, 667-684. https://doi.org/10.1111/j.1474-9726.2010.00608.x
- Wang, B., Wang, L., Gasek, N.S., Zhou, Y., Kim, T., Guo, C., Jellison, E.R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021). An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat. Aging 1, 962-973. https://doi.org/10.1038/s43587-021-00107-6
- Wang, L., Wang, B., Gasek, N.S., Zhou, Y., Cohn, R.L., Martin, D.E., Zuo, W., Flynn, W.F., Guo, C., Jellison, E.R., et al. (2022). Targeting p21(Cip1) highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 34, 75-89.e8. https://doi.org/10.1016/j.cmet.2021.11.002