대한방사성의약품학회지 (Journal of Radiopharmaceuticals and Molecular Probes)

  • 제8권2호
  • /
  • Pages.87-93
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  • 2022
  • /
  • 2384-1583(pISSN)
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  • 2508-3848(eISSN)
대한방사성의약품학회 (Korean Society of Radiopharmaceuticals and Molecular Probes)
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The Development of Radiopharmaceutical Synthesizer and its FDG Synthesis Verification

  • 투고 : 2022.12.01
  • 심사 : 2022.12.14
  • 발행 : 2022.12.30
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초록

[18F]FDG is known as the most widely used radiopharmaceutical in the imaging field of nuclear medicine worldwide. With the introduction of PET equipment, the demand for [18F]FDG has increased and the production volume has also increased. However, in order to increase production, the use of 18F radioisotope must be increased or [18F]FDG must be synthesized in high yield. Therefore, in order to meet the high yield and purity of radiopharmaceuticals, a radiopharmaceutical automatic synthesizer was required. As the use of [18F]FDG increased, automated synthesizer manufacturers supplied various types of radiopharmaceutical automated synthesizers to the market. In this study, we developed a commercialized [18F]FDG radiopharmaceutical automatic synthesizer (sCUBE FDG) using a disposable cassette type that complies with GMP developed by FutureChem, a leading radiopharmaceutical company. We used sCUBE FDG to verify the production process, radiopharmaceutical's quality (radiochemical purity, etc.), and radiochemical yield of [18F]FDG. As a result of optimizing the automatic synthesis process and synthesizing a total of 30 times, the production time was 35 ± 3 minutes and the average production yield was 65.6%.

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과제정보

The 18F radioisotope used in this study was supported by the FutureChem Cyclotron Center, Ewha Womans University Medical Center (EUMC), Republic of Korea

참고문헌

  1. Antoch G, Saoudi N, Kuehl H, Dahmen G, Mueller SP, Beyer T, Bockisch A, Debatin JF, Freudenberg LS. Accuracy of wholebody dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDGPET/CT) for tumor staging in solid tumors: comparison with CT and PET. J of clin oncol 2004;22:4357-68. https://doi.org/10.1200/JCO.2004.08.120
  2. Lee H. Horsley ed. American Chemical Society. Azeotropic Date - III; 1973.
  3. Yu S. Review of 18F-FDG synthesis and quality control. Biomed Imaging Interv J 2006;2(4):e57.
  4. Lee JH, Kim JS. A Case of Incidentally Detected nasopharyngeal Tuberculosis on F-18 FDG PET/CT. Nucl Med Mol Imaging 2008;42:482-4.
  5. Gomzina NA, Vasil'ev DA, Krasikova RN. Optimization of Automated Synthesis of 2-[18F]Fluoro-2-deoxy-D-glucose Involving Base Hydrolysis. Radiochemistry 2002;44:403-9. https://doi.org/10.1023/A:1020689314452
  6. Kim SH, Kim DI, Chi YG, Choi SW, Choi CK, Seok JD. Radiolysis Assessment of F-FDG According to Automatic Synthesis Module. J Nucl Med Technology 2012;16:8-11.
  7. Koag MC, Kim HK, Kim AS. Efficient microscale synthesis of [18F]-2-fluoro-2-deoxy-d-glucose. Chemical Engineering Journal 2014;258:62-8. https://doi.org/10.1016/j.cej.2014.07.077
  8. Kryza D, Tadino V, Filannino MA, Villeret G, Lemoucheux L. Fully automated [18F]fluorocholine synthesis in the TracerLab MXFDG Coindence synthesizer. Nucl Med Biol 2008;35(2):255-60. https://doi.org/10.1016/j.nucmedbio.2007.11.008
  9. Saxena P, Singh AK, Dixit M, Kheruka SC, Mahmood T, Gambhir S. Establishing the [18F]-FDG Production via Two Different Automated Synthesizers for Routine Clinical Studies: Our Institutional Experience of 4 years. Indian J Nucl Med 2021;36(2):120-4. https://doi.org/10.4103/ijnm.IJNM_137_20