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DOI QR Code

교태환(交泰丸)에 대한 심신부교(心腎不交)의 병기(病機)분석과 그 조성약물의 배오(配伍)분석

Pathological Analysis on Disharmony between the Heart and the Kidney for the Gyotae-hwan Formula and Compatibility Analysis on its Composition

  • 이석희 (동의대학교 대학원 한의학과 방제학교실) ;
  • 노종성 (대구한의대학교 한의과대학 방제학교실) ;
  • 신순식 (동의대학교 대학원 한의과대학 방제학교실)
  • Lee, Suk Hee (Dept. of Korean Medicine, Graduate School, Dong-Eui University) ;
  • Roh, Jong Seong (Dept. of Herbal Prescription, College of Korean Medicine, Daegu Haany University) ;
  • Shin, Soon Shik (Dept. of Formula Sciences, College of Korean Medicine and Research Center of Korean Medicine for Diabetes and Obesity, Dong-Eui University)
  • 투고 : 2022.05.11
  • 심사 : 2022.07.26
  • 발행 : 2022.08.25

초록

Objectives : The Gyotae-hwan formula has traditionally been applied to conditions of fearful throbbing[怔忡] and insomnia due to disharmony of the Heart and Kidney, of which experimental and clinical research has been carried out while those on its pathological mechanism and constituent compatibility have been inadequate. Methods : Pathological mechanism and constituent compatibility of the Gyotae-hwan formula as listed in the 『Comprehensive Medicine According to Master Han』(韓氏醫通) and the『Simple Recipes for Four Disciplines』(四科簡效方) were analyzed. Findings from recent researches searched using the keywords '交泰丸' and '교태환' in the OASIS and CNKI databases were referenced as well. Results : The Gyo-tae hwan was first mentioned in the text 『Comprehensive Medicine According to Master Han』by Mao Han in terms of constituent medicinals and application while measurements and name of formula were not listed while the concept of harmony between the Heart and Kidney was mentioned. In the『Simple Recipes for Four Discipline s』 written by Shixiong Wang, measurements of constituent medicinals, usages and name of formula were finally mentioned, along with its efficacy to treat fearful throbbing and insomnia due to disharmony between the Heart and the Kidney. Conclusions : In conclusion, the Gyo-tae hwan uses Coptidis Rhizoma as chief herb and Cinnamomi Cortex as assistant herb to change the state of disharmony between the Heart and Kidney to a harmonious state, treating insomnia and fearful throbbing.

키워드

과제정보

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술 연구개발사업 지원에 의하여 이루어진 것임(HF20C0063). 이 성과는 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2021R1F1A1052058).

참고문헌

  1. 瞿彬 외 3인. 交泰丸加减方治疗失眠症 50例. 陕西中医. 2016. 37(12). https://doi.org/10.3969/j.issn.1000-7369.2016.12.028
  2. 唐宗海 原著, 顧植山 校注. 醫易通說. 北京. 中醫古籍出版社. 1989.
  3. 杜月茹 외 8인, 陆雄. 交泰丸对 db/db 小鼠脂肪肝防治作用的实验研究. 中国中医药科技. 2016. 23(1).
  4. 罗运环 외 4인. 交泰丸治疗非酒精性脂肪肝的临床研究. 湖北中医药大学学报. 2015. 17(4). https://doi.org/10.3969/j.issn.1008-987x.2015.04.06
  5. 한국한의학연구원 전통의학정보포털 오아시스. [cited at 10 December, 2021]; Available from: https://oasis.kiom.re.kr/oasis/search/search_total.jsp?)
  6. 中國知識基礎設施工程. [cited at 20 December, 2021]; Available from: https://tra.oversea.cnki.net/kns/defaultresult/index]
  7. 金憲. 「東醫寶鑑」의 醫易思想 硏究. 경희대학교대학원. 한의철학과 박사학위논문, 2011.
  8. 雒明池 외 4인. 基于 cAMP-CREB-BDNF 信号通路探讨交泰丸抗抑郁的作用机制. 天津中医药. 2018. 35(5). https://doi.org/10.11656/j.issn.1672-1519.2018.05.12
  9. 梁如, 외 5인. 交泰丸对慢性温和不可预知性应激抑郁模型大鼠炎性细胞因子的影响. 中草药. 2018. 49(5). https://doi.org/10.7501/j.issn.0253-2670.2018.05.017
  10. 孙咪, 杨伟伟, 郭栋. "交通心肾"法组方探析. 亚太传统医药. 2018. 14(12). https://doi.org/10.11954/ytctyy.201812038
  11. 孙云龙, 庞博, 褚颖. 交泰丸的镇静催眠及抗惊厥作用. 中国老年学杂志. 2018. 38(18). https://doi.org/10.3969/j.issn.1005-9202.2018.18.060
  12. 杨帅 외 3인, 蔡雪朦, 高树明, 于春泉. 交泰丸对抑郁大鼠行为学及脑内单胺类神经递质的影响. 中草药. 2016. 47(23). https://doi.org/10.7501/j.issn.0253-2670.2016.23.017
  13. 余运龙, 全世建. 交泰丸对 PCPA失眠大鼠大脑 r-氨基丁酸及受体的影响. 时珍国医国药. 2010. 21(6).
  14. 王孟英 著. 四科簡效方. 盛增秀 主編. 王孟英醫學全書. 第1版 第3次印刷. 北京. 中國中醫藥出版社. 2005.
  15. 王雪萍 외 6인. 交泰丸中小檗碱联合 cinnamtannin D1的降血糖作用. 中成药. 2018. 40(12). https://doi.org/10.3969/j.issn.1001-1528.2018.12.001
  16. 于春泉 외 7인. 交泰丸合用盐酸氟西汀治疗抑郁症心肾不交证的临床疗效观察. 天津中医药. 2020. 37(3). https://doi.org/10.11656/j.issn.1672-1519.2020.03.13
  17. 袁琳 외 6인. 交泰丸不同配比组方降糖作用 及相关机制探讨. 中国实验方剂学杂志. 2017. 23(8). https://doi.org/10.13422/j.cnki.syfjx.2017080130
  18. 李晓芸, 杨柏灿. 心肾相交实质探析. 上海中医药杂志. 2014. 48(9). https://doi.org/10.16305/j.1007-1334.2014.09.011
  19. 张坤瑞 외 4인. 交泰丸治疗失眠症 149例临床研究. 实用中医药杂志. 1994. 4.
  20. 曹雯 외 5인. 交泰丸联合降糖康复操对 2 型糖尿病湿热困脾证患者脂联素及胰岛 β 细胞功能的影响. 中国医药导报. 2019. 16(33).
  21. 朱国双, 王岚, 王小琴. 基于 Klotho 基因的生物活性探讨中医"心肾相交"理论. 中国中医基础医学杂志. 2020. 26(2).
  22. 周圆缘, 冯亚淑. 交泰丸加减对 2 型糖尿病伴失眠患者血清脑源性神经营养因子及 5-羟色胺水平的影响. 中医学报. 2016. 31(12). https://doi.org/10.16368/j.issn.1674-8999.2016.12.528
  23. 陳士鐸 著. 辨證錄. 柳長華 主編. 陳士鐸醫學全書. 北京. 中國中醫藥出版社. 2001.
  24. 陳士鐸 著. 本草新編. 柳長華 主編. 陳士鐸醫學全書. 北京. 中國中醫藥出版社. 2001.
  25. 陈旭. 从心肾不交论治失眠. 中医临床研究. 2015. 7(31). https://doi.org/10.3969/j.issn.1674-7860.2015.31.022
  26. 祝建材. 从交泰丸谈"心肾相交理论". 中国中医基础医学杂志. 2017. 23(1).
  27. 韓懋 著, 丁光迪 點校. 韓氏醫通. 北京. 人民衛生出版社. 1989.
  28. 허준 지음, 동의문헌연구실 옮김, 진주표 주석. 新對譯 東醫寶鑑. 수정증보판. 서울. 법인문화사. 2007.