Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지
DOI QR코드

DOI QR Code

A Rare Case of Canine Huge Renal Cell Carcinoma with Ovarian Metastasis

  • Koo, Jiyoung (College of Veterinary Medicine, Jeju National University) ;
  • Song, Woo-Jin (College of Veterinary Medicine, Jeju National University) ;
  • Jo, Heesoo (College of Veterinary Medicine, Jeju National University) ;
  • Ahn, Hyerin (College of Veterinary Medicine, Jeju National University) ;
  • Choi, Solji (College of Veterinary Medicine, Jeju National University) ;
  • Jeong, Hyohoon (College of Veterinary Medicine, Jeju National University) ;
  • Cheong, Jongtae (College of Veterinary Medicine, Jeju National University) ;
  • Park, Hyun-Jung (College of Veterinary Medicine, Jeju National University) ;
  • Yun, Youngmin (College of Veterinary Medicine, Jeju National University)
  • Received : 2022.05.30
  • Accepted : 2022.07.01
  • Published : 2022.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

A 10-year-old female Pomeranian weighing 2.25 kg with a history of gradual weight loss and an intraabdominal mass confirmed with ultrasonography at a local hospital was referred to the Veterinary Medical Teaching Hospital, Jeju National University. Physical examination revealed abdominal distention. Blood analysis revealed hypoglycemia (57 mg/dL; reference range, 60-110 mg/dL). On abdominal ultrasonography, a heterogeneously hyperechoic mass measuring 7.51 × 10.6 cm was found at the level of the left kidney. Computed tomographic findings showed a unilateral left kidney mass with a 10-cm diameter and vessel contrast enhancement in the corticomedullary phase. Unilateral nephrectomy and ovariohysterectomy were performed because left ovary enlargement was observed during surgery. The renal mass was adjacent to the aorta and vena cava and attached to a portion of the small intestine, greater omentum, and left ovary. The mass was huge (12.5 × 10 × 7 cm) and was 16.5% of the body weight. Histopathological examination revealed renal cell carcinoma (RCC) and ovarian metastasis. After surgery, clinical signs improved remarkably, and serum glucose level returned to normal. As RCC is resistant to radiation and chemotherapy, the owner decided not to proceed with postoperative adjunctive therapies. To the best of our knowledge, this is the first case report of ovarian metastasis with huge RCC in a dog.

Keywords

Acknowledgement

We thank veterinary pathologists of PATH (Seoul, Korea) for providing diagnostic supports.

References

  1. Araujo DCC, da Silva MA, da Veiga CCP, Fernandes JI. Renal nephroblastoma in adult dog. Braz J Vet Med 2021; 42: e107820.
  2. Birdane FM, Hatipoglu F, Ortatatli M, Koc Y, Turgut K. Renal cell carcinoma in a dog: pathologic and cytologic findings. Revue Med Vet 2004; 155: 212-216.
  3. Bryan JN, Henry CJ, Turnquist SE, Tyler JW, Liptak JM, Rizzo SA, et al. Primary renal neoplasia of dogs. J Vet Intern Med 2006; 20: 1155-1160. https://doi.org/10.1892/0891-6640(2006)20[1155:PRNOD]2.0.CO;2
  4. Chueh KS, Yeh HC, Li CC. A huge renal cell carcinoma: case report and literature review. Urol Sci 2013; 24: 58-60. https://doi.org/10.1016/j.urols.2013.05.001
  5. DiIenno N, Han E, Maitland C, Kansara V. Hypoglycemia in renal cell carcinoma: a rare paraneoplastic syndrome. Urology 2019; 124: 10-13. https://doi.org/10.1016/j.urology.2018.10.006
  6. Edmondson EF, Hess AM, Powers BE. Prognostic significance of histologic features in canine renal cell carcinomas: 70 nephrectomies. Vet Pathol 2015; 52: 260-268. https://doi.org/10.1177/0300985814533803
  7. Insabato L, De Rosa G, Franco R, D'Onofrio V, Di Vizio D. Ovarian metastasis from renal cell carcinoma: a report of three cases. Int J Surg Pathol 2003; 11: 309-312. https://doi.org/10.1177/106689690301100408
  8. Kim H, Kang J, Kang B, Yang M. Hypoglycaemic crisis induced by non-islet cell tumours in two dogs. Vet Med 2019; 64: 407-416. https://doi.org/10.17221/145/2018-VETMED
  9. Lappin MR, Latimer KS. Hematuria and extreme neutrophilic leukocytosis in a dog with renal tubular carcinoma. J Am Vet Med Assoc 1988; 192: 1289-1292.
  10. Lee K, Jung J, Byeon Y, Oh S, Seo E, Song K, et al. Renal cell carcinoma in a Pekingese dog. J Vet Clin 2005; 22: 148-152.
  11. Leifer CE, Peterson ME, Matus RE, Patnaik AK. Hypoglycemia associated with nonislet cell tumor in 13 dogs. J Am Vet Med Assoc 1985; 186: 53-55.
  12. Lucke VM, Kelly DF. Renal carcinoma in the dog. Vet Pathol 1976; 13: 264-276. https://doi.org/10.1177/030098587601300403
  13. Martin KDJ, Sarangom SB, Krishna BND, Nair ND, Pillai UN, Philip SB, et al. Renal nephroblastoma in an adult dog- a case report. Vet Arhiv 2014; 84: 85-96.
  14. Pasca AS, Lazar M. A case report of renal cell carcinoma in a dog. Arq Bras Med Vet Zootec 2013; 65: 1286-1290. https://doi.org/10.1590/S0102-09352013000500004
  15. Sountoulides P, Metaxa L, Cindolo L. Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports. J Med Case Rep 2011; 5: 429. https://doi.org/10.1186/1752-1947-5-429
  16. Swain JM, Pirie RS, Hudson NP, Else RW, Evans H, McGorum BC. Insulin-like growth factors and recurrent hypoglycemia associated with renal cell carcinoma in a horse. J Vet Intern Med 2005; 19: 613-616. https://doi.org/10.1892/0891-6640(2005)19[613:IGFARH]2.0.CO;2
  17. Tanaka T, Akiyoshi H, Nishida H, Mie K, Lin LS, Iimori Y, et al. Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma. PLoS One 2019; 14: e0225211. https://doi.org/10.1371/journal.pone.0225211