Archives of Plastic Surgery

  • 제49권3호
  • /
  • Pages.304-309
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  • 2022
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
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Ultrasonographic Assessment of the Cutaneous Changes Induced by Topical Use of Novel Peptides Comprising Laminin 5

  • Park, Kyong Chan (Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University) ;
  • Kim, Se Young (Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University) ;
  • Khan, Galina (Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University) ;
  • Park, Eun Soo (Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University)
  • 발행 : 2022.05.15
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초록

Background Laminin 5, which is found in the basement membrane of dermal-epidermal junction (DEJ), is a major adhesive component and associated with proliferating and migrating keratinocytes. In this study, we hypothesized that the topical application of the skin care products containing the novel peptides might restore the DEJ structure by deriving deposition of laminin 5 and promoting the keratinocyte migration. Here, we evaluated the restoration of DEJ by measuring the skin thickness. Methods Single-center retrospective analysis was performed on a total of 13 patients who underwent skin care using Baume L.C.E. (France, Laboratories d' Anjou) between January and March 2021. All patients applied the skin care agent for 2 weeks only on their left hand dorsum. Before the initiation of the application and after 2 weeks, both their hands were evaluated on photography and ultrasound. And the patients were asked to rate their satisfaction with the questionnaire after 2 weeks. Results There was no obvious improvement in photographic assessment and questionnaire. The post-pre difference of skin thickness in ultrasound images was, in left hand, 0.1 ± 0.37 in distal point and 0.1 ± 0.35 in proximal point; and, in right hand, 0 ± 0.17 in distal point and 0 ± 0.15 in proximal point, respectively. The pre-post difference was statistically significant in proximal point (p = 0.035). Conclusion Topical application of novel peptide derivative comprising laminin 5 demonstrated cutaneous changes including skin thickness, as assessed by ultrasound. Further studies using other modalities including dermal density measurement, three-dimensional photography, optical coherence tomography, or skin biopsy would be helpful to determine the skin-improving effects.

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과제정보

This work was supported by the Soonchunhyang University Research Fund.

참고문헌

  1. Ryan MC, Christiano AM, Engvall E, et al. The functions of laminins: lessons from in vivo studies. Matrix Biol 1996;15(06):369-381 https://doi.org/10.1016/S0945-053X(96)90157-2
  2. Ko MS, Marinkovich MP. Role of dermal-epidermal basement membrane zone in skin, cancer, and developmental disorders. Dermatol Clin 2010;28(01):1-16
  3. Breitkreutz D, Koxholt I, Thiemann K, Nischt R. Skin basement membrane: the foundation of epidermal integrity-BM functions and diverse roles of bridging molecules nidogen and perlecan. BioMed Res Int 2013;2013:179784 https://doi.org/10.1155/2013/179784
  4. Ghohestani RF, Li K, Rousselle P, Uitto J. Molecular organization of the cutaneous basement membrane zone. Clin Dermatol 2001;19(05):551-562 https://doi.org/10.1016/S0738-081X(00)00175-9
  5. Villone D, Fritsch A, Koch M, Bruckner-Tuderman L, Hansen U, Bruckner P. Supramolecular interactions in the dermo-epidermal junction zone: anchoring fibril-collagen VII tightly binds to banded collagen fibrils. J Biol Chem 2008;283(36):24506-24513 https://doi.org/10.1074/jbc.M802415200
  6. Newton VL, Bradley RS, Seroul P, et al. Novel approaches to characterize age-related remodelling of the dermal-epidermal junction in 2D, 3D and in vivo. Skin Res Technol 2017;23(02):131-148 https://doi.org/10.1111/srt.12312
  7. Mondon P, Hillion M, Peschard O, et al. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. J Cosmet Dermatol 2015;14(02):152-160 https://doi.org/10.1111/jocd.12135
  8. Langton AK, Halai P, Griffiths CE, Sherratt MJ, Watson REB. The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction. Mech Ageing Dev 2016;156:14-16 https://doi.org/10.1016/j.mad.2016.03.006
  9. Gagnoux-Palacios L, Allegra M, Spirito F, et al. The short arm of the laminin gamma2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion. J Cell Biol 2001;153(04):835-850 https://doi.org/10.1083/jcb.153.4.835
  10. Rousselle P, Aumailley M. Kalinin is more efficient than laminin in promoting adhesion of primary keratinocytes and some other epithelial cells and has a different requirement for integrin receptors. J Cell Biol 1994;125(01):205-214 https://doi.org/10.1083/jcb.125.1.205
  11. Decline F, Rousselle P. Keratinocyte migration requires alpha2- beta1 integrin-mediated interaction with the laminin 5 gamma2 chain. J Cell Sci 2001;114(Pt 4):811-823 https://doi.org/10.1242/jcs.114.4.811
  12. Oltulu P, Ince B, Kokbudak N, Findik S, Kilinc F. Measurement of epidermis, dermis, and total skin thicknesses from six different body regions with a new ethical histometric technique. Turk J Plast Surg 2018;26:56-61 https://doi.org/10.4103/tjps.tjps_2_17
  13. Yurchenco PD. Basement membranes: cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol 2011;3(02):a004911 https://doi.org/10.1101/cshperspect.a004911
  14. Sekiguchi R, Yamada KM. Basement membranes in development and disease. Curr Top Dev Biol 2018;130:143-191 https://doi.org/10.1016/bs.ctdb.2018.02.005
  15. McKee KK, Harrison D, Capizzi S, Yurchenco PD. Role of laminin terminal globular domains in basement membrane assembly. J Biol Chem 2007;282(29):21437-21447 https://doi.org/10.1074/jbc.M702963200
  16. Ishihara J, Ishihara A, Fukunaga K, et al. Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nat Commun 2018;9(01):2163 https://doi.org/10.1038/s41467-018-04525-w
  17. Iorio V, Troughton LD, Hamill KJ. Laminins: roles and utility in wound repair. Adv Wound Care (New Rochelle) 2015;4(04):250-263 https://doi.org/10.1089/wound.2014.0533
  18. Colognato H, Yurchenco PD. Form and function: the laminin family of heterotrimers. Dev Dyn 2000;218(02):213-234 https://doi.org/10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R
  19. Aumailley M, Bruckner-Tuderman L, Carter WG, et al. A simplified laminin nomenclature. Matrix Biol 2005;24(05):326-332 https://doi.org/10.1016/j.matbio.2005.05.006
  20. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE. Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 1991;114(03):567-576 https://doi.org/10.1083/jcb.114.3.567
  21. Carter WG, Ryan MC, Gahr PJ. Epiligrin, a new cell adhesion ligand for integrin α 3 β 1 in epithelial basement membranes. Cell 1991;65(04):599-610 https://doi.org/10.1016/0092-8674(91)90092-D
  22. Roig-Rosello E, Rousselle P. The human epidermal basement membrane: a shaped and cell instructive platform that aging slowly alters. Biomolecules 2020;10(12):1607 https://doi.org/10.3390/biom10121607
  23. Jeong S, Yoon S, Kim S, et al. Anti-wrinkle benefits of peptides complex stimulating skin basement membrane proteins expression. Int J Mol Sci 2019;21(01):73 https://doi.org/10.3390/ijms21010073
  24. Crisan D, Crisan M, Moldovan M, Lupsor M, Badea R. Ultrasonographic assessment of the cutaneous changes induced by topical flavonoid therapy. Clin Cosmet Investig Dermatol 2012;5:7-13 https://doi.org/10.2147/CCID.S25840
  25. Crisan D, Lupsor M, Boca A, Crisan M, Badea R. Ultrasonographic assessment of skin structure according to age. Indian J Dermatol Venereol Leprol 2012;78(04):519
  26. Beguin A. A novel micronutrient supplement in skin aging: a randomized placebo-controlled double-blind study. J Cosmet Dermatol 2005;4(04):277-284 https://doi.org/10.1111/j.1473-2165.2005.00206.x
  27. Watson RE, Long SP, Bowden JJ, Bastrilles JY, Barton SP, Griffiths CE. Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product. Br J Dermatol 2008;158(03):472-477
  28. dal Farra C, Oberto G, Berghi A, Domloge N. An anti-aging effect on the lips and skin observed in in vivo studies on a new fibronectin-like peptide. J Am Acad Dermatol 2007;56(2, Suppl2):AB88
  29. Barba C, Mendez S, Roddick-Lanzilotta A, Kelly R, Parra JL, Coderch L. Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. Skin Res Technol 2008;14(02):243-248 https://doi.org/10.1111/j.1600-0846.2007.00280.x
  30. Barba C, Mendez S, Roddick-Lanzilotta A, Kelly R, Parra JL, Coderch L. Wool peptide derivatives for hand care. J Cosmet Sci 2007;58(02):99-107
  31. Van Mulder TJ, de Koeijer M, Theeten H, et al. High frequency ultrasound to assess skin thickness in healthy adults. Vaccine 2017;35(14):1810-1815 https://doi.org/10.1016/j.vaccine.2016.07.039