Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Effect of nonsurgical periodontal therapy and smoking status on hematological variables related to anemia of chronic disease in chronic periodontitis patient: a case-control study

  • Show, Sangita (Department of Periodontology, Trinity Dental & Maxillofacial Multispeciality Clinic) ;
  • Bagchi, Somen (Department of Periodontics, Dr. R. Ahmed Dental College and Hospital) ;
  • Dey, Arka Kanti (Department of Oral and Maxillofacial Surgery, Diamond Harbour Government Medical College and Hospital) ;
  • Boyapati, Ramanarayana (Department of Periodontology, Sibar Institute of Dental Sciences) ;
  • Pal, Pritish Chandra (Department of Periodontology, Pacific Dental College and Hospital) ;
  • Tejaswi, Kanikanti Siva (Department of Periodontology, Sibar Institute of Dental Sciences)
  • Received : 2022.01.12
  • Accepted : 2022.03.07
  • Published : 2022.07.31
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Abstract

Background: Chronic infectious, inflammatory, or neoplastic disorders are associated with anemia of chronic disease. Chronic inflammatory diseases such as periodontitis may contribute to masked anemia, especially in smokers. This study was aimed at verifying and comparing the efficacy of nonsurgical periodontal therapy (NSPT) for improving anemia among chronic periodontitis patients with and without the habit of smoking. Methods: Thirty systemically healthy individuals with chronic periodontitis were divided into two groups of 15 each, smokers (group A) and nonsmokers (group B). The groups were compared based on hematological parameters such as serum erythropoietin (SE) and serum ferritin (SF) levels at baseline and 3 months after NSPT for anemia evaluation. Results: The baseline SE levels in groups A and B were 11.84 and 15.19 mIU/mL (p=0.031), respectively; the corresponding levels at 3 months after NSPT were 13.00 and 17.74 mIU/mL (p=0.022). The baseline SF levels in groups A and B were 95.49 and 44.86 ng/mL (p=0.018), respectively; the corresponding levels at 3 months after NSPT were 77.06 and 39.05 ng/mL (p=0.009). Group B showed a significant increase and decrease in the SE and SF levels, respectively, at 3 months after NSPT (p=0.035 and p=0.039, respectively), whereas group A showed insignificant changes (p=0.253 and p=0.618, respectively). Conclusion: NSPT led to an improvement in anemia among chronic periodontitis patients. However, the improvement is less in smokers compared to that in nonsmokers. Furthermore, SF and SE levels might serve as effective biomarkers for assessing anemia in smokers and nonsmokers with chronic periodontitis.

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References

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