Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
권호 표지
DOI QR코드

DOI QR Code

Palisaded encapsulated neuroma on the lower lip: a case report

  • Seol, Jung Eun (Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Hong, Seong Min (Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Ahn, Sang Woo (Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Kim, Jong Uk (Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Jin, Woo Jung (Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Park, So Hee (Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Kim, Hyojin (Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine)
  • Received : 2021.05.02
  • Accepted : 2021.06.15
  • Published : 2022.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Palisading encapsulated neuroma is a rare, benign, cutaneous nerve sheath tumor. It usually occurs as an asymptomatic solitary skin-colored papule and commonly affects the nose and cheeks. Sometimes, it involves other sites, including the shoulder, upper arm, and trunk, but rarely involves the oral mucosa, including that of the lip. In our case, a 63-year-old female patient complained of a pinkish rubbery nodule on her lower lip. Histopathologic examination demonstrated a well-circumscribed nodule encapsulated by connective tissue stroma in the dermis. The nodule consisted of palisading spindle-shaped tumor cells with wavy and basophilic nuclei. The cells were arranged in streaming fascicles with multiple clefts and were strongly positive for S-100 proteins. To our knowledge, only three cases of palisading encapsulated neuroma on the lower lip have been reported in the Korean literature. Herein, we report a rare case of an oral palisaded encapsulated neuroma.

Keywords

References

  1. Reed RJ, Fine RM, Meltzer HD. Palisaded, encapsulated neuromas of the skin. Arch Dermatol 1972;106:865-70. https://doi.org/10.1001/archderm.1972.01620150051016
  2. Koutlas IG, Scheithauer BW. Palisaded encapsulated ("solitary circumscribed") neuroma of the oral cavity: a review of 55 cases. Head Neck Pathol 2010;4:15-26. https://doi.org/10.1007/s12105-010-0162-x
  3. Cho YH, Lee JH, Bang DS, Kim YC. A case of palisaded encapsulated neuroma of the lower lip. Korean J Dermatol 2002;40:1552-6.
  4. Cho DY, Kim DH, Choi KC, Chung BS. A case of palisaded encapsulated neuroma of the lower lip. Ann Dermatol 2006;18:37-9. https://doi.org/10.5021/ad.2006.18.1.37
  5. Lee SW, Yi JY, Cho BK, Houh W, Kim TY, Song KY. Palisaded encapsulated neuroma. Ann Dermatol 1990;2:136-40. https://doi.org/10.5021/ad.1990.2.2.136
  6. Manchanda AS, Narang RS, Puri G. Palisaded encapsulated neuroma. J Orofac Sci 2015;7:136-9. https://doi.org/10.4103/0975-8844.164308
  7. Dover JS, From L, Lewis A. Palisaded encapsulated neuromas: a clinicopathologic study. Arch Dermatol 1989;125:386-9. https://doi.org/10.1001/archderm.1989.01670150076012
  8. Val-Bernal JF, Alvarez-Canas C, Vega A. Palisaded encapsulated neuroma of the glans penis. Urology 1995;45:689-91. https://doi.org/10.1016/S0090-4295(99)80068-5
  9. Leblebici C, Savli TC, Yeni B, Cin M, Aksu AE. Palisaded encapsulated (solitary circumscribed) neuroma: a review of 30 cases. Int J Surg Pathol 2019;27:506-14. https://doi.org/10.1177/1066896919833172
  10. Dakin MC, Leppard B, Theaker JM. The palisaded, encapsulated neuroma (solitary circumscribed neuroma). Histopathology 1992;20:405-10. https://doi.org/10.1111/j.1365-2559.1992.tb01010.x
  11. Megahed M. Palisaded encapsulated neuroma (solitary circumscribed neuroma): a clinicopathologic and immunohistochemical study. Am J Dermatopathol 1994;16:120-5. https://doi.org/10.1097/00000372-199404000-00002
  12. Fletcher CD. Solitary circumscribed neuroma of the skin (socalled palisaded, encapsulated neuroma): a clinicopathologic and immunohistochemical study. Am J Surg Pathol 1989;13:574-80. https://doi.org/10.1097/00000478-198907000-00005
  13. Scolyer RA, Ferguson PM. Solitary circumscribed neuroma. In: The WHO Classification of Tumours Editorial Board, editor. WHO classification of tumours. Soft tissue and bone tumours. 5th ed. Lyon: IARC Press; 2020. p. 245-6.
  14. Kutzner H. Solitary circumscribed neuroma. In: Fletcher CD, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013. p. 181-2.
  15. Argenyi ZB, Santa Cruz D, Bromley C. Comparative light-microscopic and immunohistochemical study of traumatic and palisaded encapsulated neuromas of the skin. Am J Dermatopathol 1992;14:504-10. https://doi.org/10.1097/00000372-199212000-00003
  16. Lopes MA, Vargas PA, Almeida OP, Takahama A, Leon JE. Oral traumatic neuroma with mature ganglion cells: a case report and review of the literature. J Oral Maxillofac Pathol 2009;13:67-9. https://doi.org/10.4103/0973-029X.57672
  17. Maharudrappa B, Kumar GS. Neural tumours of oral and para oral region. Int J Dent Clin 2011;3:34-43.