DOI QR코드

DOI QR Code

Donation after Circulatory Death in Lung Transplantation

  • Hyun, Seungji (Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine) ;
  • Haam, Seokjin (Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine)
  • Received : 2022.07.12
  • Accepted : 2022.07.21
  • Published : 2022.08.05

Abstract

The shortage of donor lungs has become a serious obstacle to implementing lung transplantation (LTx). Donation after circulatory death (DCD) donors are among the several donor pools utilized to overcome the problem posed by the shortage of donation after brain death (DBD) donors. The active use of DCD donors is expected to significantly reduce mortality on the waiting list for LTx, as LTx from DCD donors has comparable outcomes to LTx from DBD donors. Further studies on efforts to shorten the warm ischemic time and use uncontrolled DCD are required.

Keywords

Acknowledgement

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

References

  1. Hardy JD, Webb WR, Dalton ML Jr, Walker GR Jr. Lung homotransplantation in man. JAMA 1963;186:1065-74.
  2. Halpern SD, Hasz RD, Abt PL. Incidence and distribution of transplantable organs from donors after circulatory determination of death in U.S. intensive care units. Ann Am Thorac Soc 2013;10:73-80. https://doi.org/10.1513/annalsats.201211-109oc
  3. Thuong M, Ruiz A, Evrard P, et al. New classification of donation after circulatory death donors definitions and terminology. Transpl Int 2016;29:749-59. https://doi.org/10.1111/tri.12776
  4. WHO; Transplantation Society (TTS); Organization Nacional de Transplantes (ONT). Third WHO Global Consultation on Organ Donation and Transplantation: striving to achieve self-sufficiency, March 23-25, 2010, Madrid, Spain. Transplantation 2011;91 Suppl 11:S27-8. https://doi.org/10.1097/TP.0b013e3182190b29
  5. Egan TM, Lambert CJ Jr, Reddick R, Ulicny KS Jr, Keagy BA, Wilcox BR. A strategy to increase the donor pool: use of cadaver lungs for transplantation. Ann Thorac Surg 1991;52:1113-21. https://doi.org/10.1016/0003-4975(91)91290-C
  6. Van Raemdonck DE, Jannis NC, De Leyn PR, Flameng WJ, Lerut TE. Warm ischemic tolerance in collapsed pulmonary grafts is limited to 1 hour. Ann Surg 1998;228:788-96. https://doi.org/10.1097/00000658-199812000-00010
  7. Kang CH, Anraku M, Cypel M, et al. Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysis. J Heart Lung Transplant 2011;30:289-98. https://doi.org/10.1016/j.healun.2010.09.004
  8. Detry O, Le Dinh H, Noterdaeme T, et al. Categories of donation after cardiocirculatory death. Transplant Proc 2012;44:1189-95. https://doi.org/10.1016/j.transproceed.2012.05.001
  9. Bernat JL, D'Alessandro AM, Port FK, et al. Report of a National Conference on Donation after cardiac death. Am J Transplant 2006;6:281-91. https://doi.org/10.1111/j.1600-6143.2005.01194.x
  10. Lewis J, Peltier J, Nelson H, et al. Development of the University of Wisconsin Donation After Cardiac Death Evaluation Tool. Prog Transplant 2003;13:265-73. https://doi.org/10.7182/prtr.13.4.w48g8051530058q3
  11. Manara AR, Murphy PG, O'Callaghan G. Donation after circulatory death. Br J Anaesth 2012;108 Suppl 1:i108-21. https://doi.org/10.1093/bja/aer357
  12. DeVita MA, Brooks MM, Zawistowski C, Rudich S, Daly B, Chaitin E. Donors after cardiac death: validation of identification criteria (DVIC) study for predictors of rapid death. Am J Transplant 2008;8:432-41. https://doi.org/10.1111/j.1600-6143.2007.02087.x
  13. Copeland H, Hayanga JW, Neyrinck A, et al. Donor heart and lung procurement: a consensus statement. J Heart Lung Transplant 2020;39:501-17. https://doi.org/10.1016/j.healun.2020.03.020
  14. Oto T, Levvey B, McEgan R, et al. A practical approach to clinical lung transplantation from a Maastricht Category III donor with cardiac death. J Heart Lung Transplant 2007;26:196-9. https://doi.org/10.1016/j.healun.2006.11.599
  15. Steen S, Sjoberg T, Pierre L, Liao Q, Eriksson L, Algotsson L. Transplantation of lungs from a non-heart-beating donor. Lancet 2001;357:825-9. https://doi.org/10.1016/S0140-6736(00)04195-7
  16. Oto T, Rabinov M, Griffiths AP, et al. Unexpected donor pulmonary embolism affects early outcomes after lung transplantation: a major mechanism of primary graft failure? J Thorac Cardiovasc Surg 2005;130:1446.
  17. Okazaki M, Date H, Inokawa H, et al. Optimal time for post-mortem heparinization in canine lung transplantation with non-heart-beating donors. J Heart Lung Transplant 2006;25:454-60. https://doi.org/10.1016/j.healun.2005.08.017
  18. de Antonio DG, Marcos R, Laporta R, et al. Results of clinical lung transplant from uncontrolled non-heart-beating donors. J Heart Lung Transplant 2007;26:529-34. https://doi.org/10.1016/j.healun.2007.01.028
  19. Van Raemdonck D, Keshavjee S, Levvey B, et al. Donation after circulatory death in lung transplantation: five-year follow-up from ISHLT Registry. J Heart Lung Transplant 2019;38:1235-45. https://doi.org/10.1016/j.healun.2019.09.007
  20. Chambers DC, Cherikh WS, Harhay MO, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult lung and heartlung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant 2019;38:1042-55. https://doi.org/10.1016/j.healun.2019.08.001
  21. Villavicencio MA, Axtell AL, Spencer PJ, et al. Lung transplantation from donation after circulatory death: United States and single-center experience. Ann Thorac Surg 2018;106:1619-27. https://doi.org/10.1016/j.athoracsur.2018.07.024
  22. Levvey BJ, Harkess M, Hopkins P, et al. Excellent clinical outcomes from a national donation-after-determination-of-cardiac-death lung transplant collaborative. Am J Transplant 2012;12:2406-13. https://doi.org/10.1111/j.1600-6143.2012.04193.x
  23. Krutsinger D, Reed RM, Blevins A, et al. Lung transplantation from donation after cardiocirculatory death: a systematic review and meta-analysis. J Heart Lung Transplant 2015;34:675-84. https://doi.org/10.1016/j.healun.2014.11.009