Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Hepatic and Renal Safety of Concurrent Use of Conventional and Herbal Medications for Musculoskeletal Disorders: A Retrospective Observational Study

근골격계 질환에 대한 양약 및 한약 병용의 간과 신장에 대한 안전성: 후향적 관찰 연구

  • Kim, Se-Yoon (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Hyungsuk (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kang, Doyoung (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ko, Junhyuk (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Jongyeon (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Koh-Woon (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Bo-Hyung (East-West Medical Research Institute, Kyung Hee University) ;
  • Cho, Jae-Heung (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Song, Mi-Yeon (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Chung, Won-Seok (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 김세윤 (경희대학교 대학원 임상한의학과) ;
  • 김형석 (경희대학교 대학원 임상한의학과) ;
  • 강도영 (경희대학교 대학원 임상한의학과) ;
  • 고준혁 (경희대학교 대학원 임상한의학과) ;
  • 김종연 (경희대학교 대학원 임상한의학과) ;
  • 김고운 (경희대학교 대학원 임상한의학과) ;
  • 김보형 (경희대학교 동서의학연구소) ;
  • 조재흥 (경희대학교 대학원 임상한의학과) ;
  • 송미연 (경희대학교 대학원 임상한의학과) ;
  • 정원석 (경희대학교 대학원 임상한의학과)
  • Received : 2022.06.21
  • Accepted : 2022.06.28
  • Published : 2022.07.31
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Abstract

Objectives This study aimed to investigate whether the concurrent use of conventional and herbal medications affects liver and kidney function, by examining blood test data. Methods We retrospectively reviewed the electronic medical records of 590 inpatients with musculoskeletal diseases between 2013 and 2017. We investigated cases of drug-induced liver injury (DILI) according to the Roussel Uclaf Causality Assessment Method criteria and cases of drug-induced kidney injury (DIKI) based on the Kidney Disease Improving Global Outcomes definition. Results One case (0.17%) of DILI and one case (0.17%) of DIKI were identified. Significant improvements in serum laboratory data were observed after the concurrent use of both types of medications (p<0.05). The kappa coefficients ranged from 0.26 to 0.72, indicating that the values after the concurrent use of conventional and herbal medications showed a fair similarity to the baseline values of the patients. The linear regression test showed that female sex and high body mass index (BMI) were risk factors for an increase in the serum blood levels of liver function parameters. Conclusions The concurrent use of conventional and herbal medications for musculoskeletal disorders is relatively safe; however, clinicians should exercise caution when prescribing these medications to female patients and patients with a high BMI because of their potential effect on hepatic function.

Keywords

Acknowledgement

The authors thank Jae-Hyun Park, Hokyung Chang, and Hansol Lee from Kyung Hee University Korean Medicine Hospital for providing assistance in the analysis process.

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