The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Protective effects of Dioscorea batas Decaisne water extract on acute pancreatitis

산약(山藥) 물 추출물의 급성 췌장염 보호 효과

  • Kweon, Bitna (Department of Pharmacology, School of Korean Medicine, Wonkwang University) ;
  • Bae, Gi-Sang (Department of Pharmacology, School of Korean Medicine, Wonkwang University)
  • 권빛나 (원광대학교 한의과대학 약리학교실) ;
  • 배기상 (원광대학교 한의과대학 약리학교실)
  • Received : 2022.06.14
  • Accepted : 2022.07.25
  • Published : 2022.07.30
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Abstract

Objectives : Dioscorea batas Decaisne (DB) has been known to be good for the digestive system on Eastern Asia. However, the protective effect of DB on acute pancreatitis (AP) has not been studied. In this study, we tried to investigate the protective effect of DB water extract on caerulein-induced AP. Methods : To measure the protective effect of DB on AP, Mice were injected with cholecystokinin analogue caerulein (50 ㎍/kg) hourly for 6 times. DB water extract (200 or 400 mg/kg) or saline (control group) was administered orally 1 h before the first injection of caerulein. The mice were sacrificed at 6 h after the last injection of caerulein. The pancreas tissues and serum samples were immediately taken for further analysis. Results : Administration of DB water extract showed the inhibitory effect on the increase of pancreas weight/body weight ratio, pancreatic histological damage. And the rise of serum lipase level was significantly reduced in DB water extract treatment group during AP in mice. However administration of DB water extract did not show significant reduction in serum amylase level. Also, mRNA levels of pro-inflammatory cytokines Interleukin (IL)-6 and Tumor necrosis factor (TNF)-𝛼 but not IL-1𝛽 were inhibited by administration of DB water extract. Conclusions : Taken together, we found that administration of DB water extract ameliorates the severity of caerulein-induced AP, which suggests the potential to be an effective treatment on AP.

Keywords

Acknowledgement

이 논문은 2019년 정부(교육부)의 재원으로 한국연구재단의지원을 받아 수행된 연구임(한국연구재단-2019-글로벌박사양성사업-2019H1A2A1076626). 이 성과는 정부(교육부/과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2019R1A2C1090032/2021R1I1A2053285).

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