대한본초학회지 (The Korea Journal of Herbology)

  • 제37권4호
  • /
  • Pages.49-57
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  • 2022
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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Streptozotocin으로 유발된 흰쥐의 당뇨 증상 개선에 미치는 한약재 첨가 청국장 추출물의 영향

Effects of Herbal Medicine-added Cheonggugjang extract on Improvement of the Symptoms in Streptozotocin-induced Diabetic Rats

  • 조창숙 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김소영 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 최문열 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김미형 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 고경아 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김미려 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 서부일 (대구한의대학교 한의과대학 본초약리학교실)
  • Jo, Chang Suk (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, So Young (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Choi, Moon-Yeol (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Mi Hyung (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Ko, Kyung A (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Mi Ryeo (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Seo, Bu-il (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University)
  • 투고 : 2022.06.13
  • 심사 : 2022.07.25
  • 발행 : 2022.07.30
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초록

Objective : This study was conducted to investigate antidiabetic effects of chunggugjang with medicinal herbal complex (CJ) in streptozotocin (STZ)-induced animal models. Method : STZ (65 mg/kg) was injected intraperitoneally to induce diabetes. Then rats were divided into 5 groups ; NG (normal diet + 0.9% saline), COS (STZ +saline 5 mL/kg), COB (STZ + fermented soybean(100 mg/kg), CJ 100/200 (STZ+CJ(100 and 200 mg/kg), CJ 300/600 (STZ+CJ(300 and 600 mg/kg). 4 weeks later, oral glucose tolerance test (OGTT) was performed. After sacrificing rats, serum levels of blood urea nitrogen (BUN), creatinine, aspartate amino transferase (AST), alanine amino transferase (ALT), total cholesterol (TC), and triglyceride (TG) were measured and histological changes were observed. Result : Body weight change and food efficiency ratio (FER) were decreased in the CJ 300/600 group than in the COS group. But, there was no change in water intake. Serum levels of glucose, AST, ALT and BUN were lower in the CJ 300/600 group than in the COS group. Also, TG, TC, and creatinine were decreased in the CJ 300/600 group than in the COS group. According to OGTT, 120 minutes postprandial glucose levels were lower in the CJ 300/600 group than in the COS group. In addition, administration of CJ extracts restored histopathological damage. Conclusion : The results suggest that CJ can be used as a functional material for diabetes treatment as it has the effect to improve pathological symptoms in STZ-induced diabetic rats.

키워드

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