Acknowledgement
The current research was supported by Innovation Ability Promotion Project for Technology-based Small and Medium Enterprise in Shandong Province (2021TSGC1271, 2021TSGC1275), Shandong Provincial Central Government Guides Local Technology Development Fund Projects (YDZX20203700003775).
References
- Ertekin T, Bilir A, Aslan E, Koca B, Turamanlar O, Ertekin A, et al. The effect of diclofenac sodium on neural tube development in the early stage of chick embryos. Folia Morphol (Warsz). 2019;78(2):307-313. https://doi.org/10.5603/fm.a2018.0080
- Bertocchi P, Antoniella E, Valvo L, Alimonti S, Memoli A. Diclofenac sodium multisource prolonged release tablets--a comparative study on the dissolution profiles. J Pharm Biomed Anal. 2005;37(4):679-685. https://doi.org/10.1016/j.jpba.2004.11.041
- Gan TJ. Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin. 2010;26(7):1715-1731. https://doi.org/10.1185/03007995.2010.486301
- Sharma S, Setia H, Toor AP. Assessing the bioremediation potential of indigenously isolated Klebsiella sp. WAH1 for diclofenac sodium: optimization, toxicity and metabolic pathway studies. World J Microbiol Biotechnol. 2021;37(2):33. https://doi.org/10.1007/s11274-021-02998-4
- Menasse R, Hedwall PR, Kraetz J, Pericin C, Riesterer L, Sallmann A, et al. Pharmacological properties of diclofenac sodium and its metabolites. Scand J Rheumatol Suppl. 1978;7(22):5-16.
- Swan GE, Cuthbert R, Quevedo M, Green RE, Pain DJ, Bartels P, et al. Toxicity of diclofenac to Gyps vultures. Biol Lett. 2006;2(2):279-282. https://doi.org/10.1098/rsbl.2005.0425
- Green RE, Taggart MA, Das D, Pain DJ, Sashi Kumar C, Cunningham AA, et al. Collapse of Asian vulture populations: risk of mortality from residues of the veterinary drug diclofenac in carcasses of treated cattle. J Appl Ecol. 2006;43(5):949-956. https://doi.org/10.1111/j.1365-2664.2006.01225.x
- Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, et al. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature. 2004;427(6975):630-633. https://doi.org/10.1038/nature02317
- Galligan TH, Mallord JW, Prakash VM, Bhusal KP, Alam AS, Anthony FM, et al. Trends in the availability of the vulture-toxic drug, diclofenac, and other NSAIDs in South Asia, as revealed by covert pharmacy surveys. Bird Conserv Int. 2021;31(3):337-353. https://doi.org/10.1017/S0959270920000477
- Paudel K, Amano T, Acharya R, Chaudhary A, Baral HS, Bhusal KP, et al. Population trends in Himalayan Griffon in Upper Mustang, Nepal, before and after the ban on diclofenac. Bird Conserv Int. 2016;26(3):286-292. https://doi.org/10.1017/S0959270915000192
- Hussain I, Khan MZ, Khan A, Javed I, Saleemi MK. Toxicological effects of diclofenac in four avian species. Avian Pathol. 2008;37(3):315-321. https://doi.org/10.1080/03079450802056439
- Naidoo V, Swan GE. Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction. Comp Biochem Physiol C Toxicol Pharmacol. 2009;149(3):269-274. https://doi.org/10.1016/j.cbpc.2008.07.014
- Nethathe B, Chipangura J, Hassan IZ, Duncan N, Adawaren EO, Havenga L, et al. Diclofenac toxicity in susceptible bird species results from a combination of reduced glomerular filtration and plasma flow with subsequent renal tubular necrosis. PeerJ. 2021;9:e12002. https://doi.org/10.7717/peerj.12002
- Sun C, Lin S, Li Z, Liu H, Liu Y, Wang K, et al. iTRAQ-based quantitative proteomic analysis reveals the toxic mechanism of diclofenac sodium on the kidney of broiler chicken. Comp Biochem Physiol C Toxicol Pharmacol. 2021;249:109129. https://doi.org/10.1016/j.cbpc.2021.109129
- Xie J, Dong W, Liu R, Wang Y, Li Y. Research on the hepatotoxicity mechanism of citrate-modified silver nanoparticles based on metabolomics and proteomics. Nanotoxicology. 2018;12(1):18-31. https://doi.org/10.1080/17435390.2017.1415389
- Aslam B, Basit M, Nisar MA, Khurshid M, Rasool MH. Proteomics: technologies and their applications. J Chromatogr Sci. 2017;55(2):182-196. https://doi.org/10.1093/chromsci/bmw167
- Akter R, Sarker M. Effect of diclofenac sodium in broilers. Bangladesh J Vet Med. 2015;13(1):19-24. https://doi.org/10.3329/bjvm.v13i1.23710
- Ramzan M, Ashraf M, Hashmi H, Iqbal Z, Anjum A. Evaluation of diclofenac sodium toxicity at different concentrations in relation to time using broiler chicken model. J Anim Plant Sci. 2015;25(2):357-365.
- Kannan K, Jain SK. Oxidative stress and apoptosis. Pathophysiology. 2000;7(3):153-163. https://doi.org/10.1016/S0928-4680(00)00053-5
- Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V. Role of apoptosis in disease. Aging (Albany NY). 2012;4(5):330-349. https://doi.org/10.18632/aging.100459
- Hassan IZ, Duncan N, Adawaren EO, Naidoo V. Could the environmental toxicity of diclofenac in vultures been predictable if preclinical testing methodology were applied? Environ Toxicol Pharmacol. 2018;64:181-186. https://doi.org/10.1016/j.etap.2018.10.006
- Naidoo V, Duncan N, Bekker L, Swan G. Validating the domestic fowl as a model to investigate the pathophysiology of diclofenac in Gyps vultures. Environ Toxicol Pharmacol. 2007;24(3):260-266. https://doi.org/10.1016/j.etap.2007.06.003
- Cuthbert RJ, Taggart MA, Saini M, Sharma A, Das A, Kulkarni MD, et al. Continuing mortality of vultures in India associated with illegal veterinary use of diclofenac and a potential threat from nimesulide. Oryx. 2016;50(1):104-112. https://doi.org/10.1017/S003060531500037X
- Goda K, Takahashi T, Kobayashi A, Shoda T, Kuno H, Sugai S. Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury. J Toxicol Sci. 2016;41(5):605-615. https://doi.org/10.2131/jts.41.605
- Boonyong C, Vardhanabhuti N, Jianmongkol S. Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death by reducing endoplasmic reticulum stress regardless of their direct reactive oxygen species scavenging capacity. J Pharm Pharmacol. 2020;72(4):583-591. https://doi.org/10.1111/jphp.13227
- Fecker LF, Stockfleth E, Braun FK, Rodust PM, Schwarz C, Kohler A, et al. Enhanced death ligandinduced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP. J Invest Dermatol. 2010;130(8):2098-2109. https://doi.org/10.1038/jid.2010.40
- Yamazaki T, Muramoto M, Oe T, Morikawa N, Okitsu O, Nagashima T, et al. Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling. Neuropharmacology. 2006;50(5):558-567. https://doi.org/10.1016/j.neuropharm.2005.10.016
- Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of vitamin A in the immune system. J Clin Med. 2018;7(9):258. https://doi.org/10.3390/jcm7090258
- Khillan JS. Vitamin A/retinol and maintenance of pluripotency of stem cells. Nutrients. 2014;6(3):1209-1222. https://doi.org/10.3390/nu6031209
- Tanumihardjo SA, Russell RM, Stephensen CB, Gannon BM, Craft NE, Haskell MJ, et al. Biomarkers of nutrition for development (BOND)-vitamin A review. J Nutr. 2016;146(9):1816S-1848S. https://doi.org/10.3945/jn.115.229708
- Ford ES, Mokdad AH, Giles WH, Brown DW. The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes. 2003;52(9):2346-2352. https://doi.org/10.2337/diabetes.52.9.2346
- Jin L, Yan S, Shi B, Shi H, Guo X, Li J. Retinoic acid attenuates oxidative injury in bovine mammary epithelial cells induced by hydrogen peroxide. Czech J Anim Sci. 2017;62(12):539-548. https://doi.org/10.17221/42/2016-CJAS
- Shi HY, Yan SM, Guo YM, Zhang BQ, Guo XY, Shi BL. Vitamin A pretreatment protects NO-induced bovine mammary epithelial cells from oxidative stress by modulating Nrf2 and NF-κB signaling pathways. J Anim Sci. 2018;96(4):1305-1316. https://doi.org/10.1093/jas/sky037
- Jiang H, Dan Z, Wang H, Lin J. Effect of ATRA on contents of liver retinoids, oxidative stress and hepatic injury in rat model of extrahepatic cholestasis. J Huazhong Univ Sci Technolog Med Sci. 2007;27(5):491-494. https://doi.org/10.1007/s11596-007-0503-5
- Dal-Pizzol F, Klamt F, Benfato MS, Bernard EA, Moreira JC. Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat Sertoli cells. Free Radic Res. 2001;34(4):395-404. https://doi.org/10.1080/10715760100300331
- Borghi C, Virdis A. Serum urate, uricase, and blood pressure control in gout. Hypertension. 2019;74(1):23-25. https://doi.org/10.1161/hypertensionaha.119.12831
- Werner AK, Witte CP. The biochemistry of nitrogen mobilization: purine ring catabolism. Trends Plant Sci. 2011;16(7):381-387. https://doi.org/10.1016/j.tplants.2011.03.012
- Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016;213:8-14. https://doi.org/10.1016/j.ijcard.2015.08.109
- Krebs HA. Regulatory mechanisms in purine biosynthesis. Adv Enzyme Regul. 1977;16:409-422. https://doi.org/10.1016/0065-2571(78)90086-9
- Zhang Y, Morar M, Ealick SE. Structural biology of the purine biosynthetic pathway. Cell Mol Life Sci. 2008;65(23):3699-3724. https://doi.org/10.1007/s00018-008-8295-8