The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Clinical Effect of Gyeongok-go: A Systematic Review of Randomized Controlled Trials

경옥고의 임상 효능 : 체계적 고찰

  • Kang, Heekyung (Dept. of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Han, Changwoo (Dept. of Internal Medicine, Korean Medicine Hospital of Pusan National University)
  • 강희경 (부산대학교한방병원 한방내과) ;
  • 한창우 (부산대학교한방병원 한방내과)
  • Received : 2022.06.07
  • Accepted : 2022.06.29
  • Published : 2022.06.30
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Abstract

Purpose: The purpose of this study was to confirm the clinical efficacy of Gyeongok-go. Methods: Public/Publisher MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), Excerpta Medica dataBASE (EMBASE), Research Information Sharing Service (RISS), ScienceON, Korean Traditional Knowledge Portal (KTKP), and China National Knowledge Infrastructure (CNKI) were searched for randomized controlled clinical trials administering Gyeongok-go as an intervention, published from inception to December 31, 2021. The risk-of-bias of the included trials was assessed with the Cochrane risk-of-bias tool for randomized trials version 2. From the experimental and control groups of the selected trials, the mean value (or rate) of each outcome was extracted and statistically compared. Results: Statistically significant mean differences were in VO2max (MD 6.82), post-exercise heart rate (MD -8.76 at 5 min, -11.58 at 30 min, -14.6 at 60 min), senescence scale (MD -6.52), Th1 cells and Th2 cells in pulmonary tuberculosis (MD 2.79 and -1.64), yin-deficient and qi-deficient score (MD -9.64 and -9.76), and phlegm-dampness score (MD 5.56). Overall risk-of-bias was 20% low risk, 80% some concerns, and 0% high risk. There were no reports of adverse events. Conclusions: Gyeongok-go is likely to have the effect of improving cardiorespiratory endurance, increasing fatigue recovery ability, reducing senescence, and enhancing immune function in tuberculosis patients. Also, it is more suitable for those who are yin-deficient or qi-deficient, and those with phlegm-dampness probably need caution.

Keywords

Acknowledgement

본 연구는 2021년도 부산대학교병원 임상연구비 지원으로 이루어 졌음.

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