Journal of Digestive Cancer Research

Korean Society of Gastrointestinal Cancer Research (대한소화기암연구학회)
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Immunotherapy for the Treatment of Gastric Cancer with High Microsatellite Instability

고빈도-현미부수체 불안정성(High Microsatellite Instability) 위암 환자의 면역치료

  • Seoyoung Lee (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • 이서영 (연세대학교 강남세브란스병원 내과학교실)
  • Received : 2022.11.07
  • Accepted : 2022.11.15
  • Published : 2022.12.01
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Abstract

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References

  1. Kloor M, von Knebel Doeberitz M. The immune biology of microsatellite-unstable cancer. Trends Cancer 2016;2:121-133. https://doi.org/10.1016/j.trecan.2016.02.004 
  2. Keytruda (pembrolizumab). Package insert. 2019. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125514s040lbl.pdf (accessed January 26, 2021). 
  3. Hause RJ, Pritchard CC, Shendure J, Salipante SJ. Classification and characterization of microsatellite instability across 18 cancer types. Nat Med 2016;22:1342-1350. Erratum in: Nat Med 2017;23:1241. Erratum in: Nat Med 2018;24:525. https://doi.org/10.1038/nm.4191 
  4. Chao J, Fuchs CS, Shitara K, et al. Assessment of pembrolizumab therapy for the treatment of microsatellite instability-high gastric or gastroesophageal junction cancer among patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 clinical trials. JAMA Oncol 2021;7:895-902. https://doi.org/10.1001/jamaoncol.2021.0275 
  5. National Comprehensive Cancer Network. Gastric cancer version 4. 2020. https://www.nccn.org/guidelines/recently-published-guidelines (accessed January 29, 2021). 
  6. Moehler M, Shitara K, Garrido M, et al. LBA6_PR nivolumab (nivo) plus chemotherapy (chemo) versus chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC)/esophageal adenocarcinoma (EAC): first results of the CheckMate 649 study. Ann Oncol 2020;31(Suppl 4):S1191. https://doi.org/10.1016/j.annonc.2020.08.2296 
  7. Pietrantonio F, Miceli R, Raimondi A, et al. Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer. J Clin Oncol 2019;37:3392-3400. https://doi.org/10.1200/JCO.19.01124