Journal of Digestive Cancer Research

  • 제10권2호
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  • Pages.99-106
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  • 2022
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  • 2950-9394(pISSN)
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  • 2950-9505(eISSN)
대한소화기암연구학회 (Korean Society of Gastrointestinal Cancer Research)
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R을 이용한 결과 변수에 따른 최적의 Cut-off Point 결정

Determining the Optimal Cut-off Point According to the Outcome Variables Using R

  • 양주연 (연세대학교 의과대학 의학통계지원실) ;
  • 이혜선 (연세대학교 의과대학 의학통계지원실)
  • Juyeon Yang (Biostatistics Collaboration Unit, Yonsei University College of Medicine) ;
  • Hye Sun Lee (Biostatistics Collaboration Unit, Yonsei University College of Medicine)
  • 투고 : 2022.10.28
  • 심사 : 2022.11.12
  • 발행 : 2022.12.01
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초록

Clinical research ultimately aimed to promptly diagnose and prevent diseases through precise biomarker development. Finding the optimal cut-off point of a regularly measured biomarker can help its interpretation and ultimately help in disease investigation and diagnosis, more specifically in determining the presence of diseases. Therefore, this study aimed to use the characteristics of outcome variables in clinical research to explain how to determine the optimal cutoff point. The outcome variables can be divided into dichotomous, ordinal, and survival types. The optimal cut-off point can be determined by finding points that maximize the Youden index, extended Youden index, and log-rank statistics. This study will enable clinical researchers to accurately determine the optimal cut-off points for regularly measured biomarkers, thereby enabling prompt disease diagnosis for effective treatment.

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참고문헌

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