Journal of Digestive Cancer Research

Korean Society of Gastrointestinal Cancer Research (대한소화기암연구학회)
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Helicobacter pylori and Gastroesophageal Reflux Disease

헬리코박터 파일로리 감염과 위식도역류질환

  • Yeon-Ji Kim (Division of Gastroenterology, Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University)
  • 김연지 (노원을지대학교병원 내과학교실 소화기내과)
  • Received : 2022.11.01
  • Accepted : 2022.11.15
  • Published : 2022.12.01
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Abstract

Helicobacter pylori (H. pylori) infection is associated with gastroduodenal diseases such as gastritis, peptic ulcer diseases, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. Furthermore, various extragastroduodenal diseases have been suggested to be related with H. pylori infection. Although no single factor has been considered the cause of gastroesophageal reflux disease (GERD), a negative association was found between the prevalence of H. pylori and GERD severity. Additionally, the role of eradication therapy of H. pylori in reflux esophagitis is controversial, and a significant correlation was found between successful H. pylori eradication rate and reflux esophagitis development. H. pylori infection remains an inconclusive and important issue in GERD. Thus, more experimental studies are necessary to elucidate the potential mechanisms.

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References

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