DOI QR코드

DOI QR Code

Endoscopic Management of Gastric Subepithelial Tumor

위상피하종양의 내시경적 진단 및 치료

  • Hyunchul Lim (Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine)
  • 임현철 (연세대학교 의과대학 용인세브란스병원 내과학교실)
  • Received : 2022.05.06
  • Accepted : 2022.05.20
  • Published : 2022.06.01

Abstract

Diagnosis of gastric subepithelial tumors (SETs) is sometimes difficult with conventional endoscopy or tissue sampling with standard biopsy, so non-invasive imaging modalities such as endoscopic ultrasound (EUS) and computed tomography are used to evaluate the characteristics of SETs features (size, location, originating layer, echogenicity, shape). However imaging modalities alone is not able to distinguish among all types of SETs, so histology is the gold standard for obtaining the final diagnosis. For tissue sampling, mucosal cutting biopsy and mucosal incision-assisted biopsy and EUS-guided fine-needle aspiration or biopsy (EUS-FNA or EUS-FNB) is commonly recommended. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are used for resection of SETs involving the mucosal and superficial submucosal layers, could not treat adequately and safely the SETs involving the deep mucosa and muscularis propria. Submucosal tunneling endoscopic resection (STER) and endoscopic full-thickness resection (EFTR) is used as a therapeutic option for the treatment of SETs with the development of reliable endoscopic closure techniques and tools.

Keywords

References

  1. Lee JH, Lee HL, Ahn YW, et al. Prevalence of gastric subepithelial tumors in Korea: a single center experience. Korean J Gastroenterol 2015;66:274-276. https://doi.org/10.4166/kjg.2015.66.5.274
  2. Yasuda K, Cho E, Nakajima M, Kawai K. Diagnosis of submucosal lesions of the upper gastrointestinal tract by endoscopic ultrasonography. Gastrointest Endosc 1990;36(2 Suppl):S17-S20. https://doi.org/10.1016/S0016-5107(90)71010-3
  3. Deprez PH, Moons LMG, O'Toole D, et al. Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2022;54:412-429. https://doi.org/10.1055/a-1751-5742
  4. Kaneko E, Kumagai J, Honda N, Nakamura S, Kino I. Evaluation of the new giant-biopsy forceps in the diagnosis of mucosal and submucosal gastric lesions. Endoscopy 1983;15:322-326. https://doi.org/10.1055/s-2007-1021545
  5. Cantor MJ, Davila RE, Faigel DO. Yield of tissue sampling for subepithelial lesions evaluated by EUS: a comparison between forceps biopsies and endoscopic submucosal resection. Gastrointest Endosc 2006;64:29-34. https://doi.org/10.1016/j.gie.2006.02.027
  6. Goto O, Kaise M, Iwakiri K. Advancements in the diagnosis of gastric subepithelial tumors. Gut Liver 2022;16:321-330. https://doi.org/10.5009/gnl210242
  7. Zhang XC, Li QL, Yu YF, et al. Diagnostic efficacy of endoscopic ultrasound-guided needle sampling for upper gastrointestinal subepithelial lesions: a meta-analysis. Surg Endosc 2016;30:2431-2441. https://doi.org/10.1007/s00464-015-4494-1
  8. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006; 130:1466-1478. https://doi.org/10.5858/2006-130-1466-GSTROM
  9. Facciorusso A, Sunny SP, Del Prete V, Antonino M, Muscatiello N. Comparison between fine-needle biopsy and fine-needle aspiration for EUS-guided sampling of subepithelial lesions: a meta-analysis. Gastrointest Endosc 2020;91:14-22.e2. https://doi.org/10.1016/j.gie.2019.07.018
  10. Webb K, Hwang JH. Endoscopic ultrasound-fine needle aspiration versus core biopsy for the diagnosis of subepithelial tumors. Clin Endosc 2013;46:441-444. https://doi.org/10.5946/ce.2013.46.5.441
  11. Standards of Practice Committee, Faulx AL, Kothari S, et al. The role of endoscopy in subepithelial lesions of the GI tract. Gastrointest Endosc 2017;85:1117-1132. https://doi.org/10.1016/j.gie.2017.02.022
  12. Park JJ. Long-term outcomes after endoscopic treatment of gastric gastrointestinal stromal tumor. Clin Endosc 2016;49:232-234.
  13. Lee SH, Park JH, Park DH, et al. Endoloop ligation of large pedunculated submucosal tumors (with videos). Gastrointest Endosc 2008;67:556-560. https://doi.org/10.1016/j.gie.2007.10.049
  14. Park YS, Park SW, Kim TI, et al. Endoscopic enucleation of upper-GI submucosal tumors by using an insulated-tip electrosurgical knife. Gastrointest Endosc 2004;59:409-415. https://doi.org/10.1016/S0016-5107(03)02717-2
  15. He Z, Sun C, Zheng Z, et al. Endoscopic submucosal dissection of large gastrointestinal stromal tumors in the esophagus and stomach. J Gastroenterol Hepatol 2013;28:262-267. https://doi.org/10.1111/jgh.12056
  16. Lv XH, Wang CH, Xie Y. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors: a systematic review and meta-analysis. Surg Endosc 2017;31:49-63.  https://doi.org/10.1007/s00464-016-4978-7