Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of the Extract of Stachys Affinis on DNFB-induced Allergic Contact Dermatitis in Mice

DNFB에 의해 알레르기성 접촉성 피부염이 유도된 마우스에서 초석잠 추출물의 효과

  • Lee, Yun-seong (Graduate School of Food Industry Convergence, Wonkwang University) ;
  • Jeong, Sun Oh (Department of Immunology, School of Medicine, Wonkwang University) ;
  • Pae, Hyun-Ock (Graduate School of Food Industry Convergence, Wonkwang University)
  • 이윤성 (원광대학교 식품산업융복합학과) ;
  • 정선오 (원광대학교 의과대학 면역학교실) ;
  • 배현옥 (원광대학교 식품산업융복합학과)
  • Received : 2021.11.08
  • Accepted : 2022.02.24
  • Published : 2022.02.25
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Abstract

This study aims to evaluate the anti-inflammatory effect of 80% ethanol extracts of Stachys affinis (MQ) on 1-fluoro-2,4-Dinitrofluorobenzene (DNFB) induced atopic dermatitis (AD) in Balb/c mice. AD-like allergic contact dermatitis was induced by challenge of DNFB on the ear after DNFB sensitization on the back sides of mice. MQ alleivated clinical severity in AD-like skin lesions. In addition, ear thickness of epidermis and penetration of inflammatory cells in AD-like skin lesions were decreased by topical application of MQ. The the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) were measured in AD mice using ELISA kits. Levels of TNF-α and IL-4 in serum were significantly decreased by topical application of MQ. Therefore, this study could give a clinical basis that MQ could be a agent to prevent AD.

Keywords

References

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