Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Emerging Mechanisms of Cyr61/CTGF/NOV Secretion in the Nervous System

  • Yang, Hayoung (Department of Biochemistry, Chungbuk National University) ;
  • Park, Young-Jun (Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Shim, Sungbo (Department of Biochemistry, Chungbuk National University)
  • Received : 2022.05.17
  • Accepted : 2022.06.02
  • Published : 2022.06.30
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Abstract

The Cyr61/CTGF/NOV (CCN) family is dynamically expressed in various tissues, including the nervous system, from the prenatal period to adulthood. However, major studies have been conducted only in limited fields, such as the cardiovascular and muscular systems, skeletal development, and cancer. In addition, although the CCN family is a secretory protein, very few studies have described its mechanism of secretion. Recently, it has been suggested that overexpression of CCN3 or intracellular accumulation due to problems in the secretory pathway can inhibit neuronal axonal growth. In this review, we have briefly summarized the structure and characteristics of the CCN family and its related diseases, with particular emphasis on the secretory mechanism and modifiers of the CCN family, newly identified in the nervous system.

Keywords

Acknowledgement

This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017M3C7A1046154, 2020R1A6A1A06046235, 2022R1I1A1A01068448) and the KRIBB Research Initiative Program (KGM 5322214).

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