대한의생명과학회지 (Biomedical Science Letters)

  • 제28권2호
  • /
  • Pages.120-126
  • /
  • 2022
  • /
  • 1738-3226(pISSN)
  • /
  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Angelica gigas Nakai on Immune Enhancement in Cyclophosphamide-induced Immune-suppressed Mice

  • Seo, Byung-cheol (Research Institute of Nutragen) ;
  • Kim, Su-Jin (Department of Biotechnology and Convergence, Daegu Haany University)
  • 투고 : 2022.06.02
  • 심사 : 2022.06.28
  • 발행 : 2022.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Natural products are important sources for drug development because they have a wide variety of useful biological properties. Angelica gigas Nakai (AGN) has been used as an herbal medicine. The present study was designed to evaluate the immune-enhancing effect of AGN in the cyclophosphamide (CP) induced immune-suppressed mice. As the result, we found that CP induced the reductions of body ratio, spleen weights, hematopoietic parameter and cytokine productions in mice. However, AGN recovered immunosuppression-mediated decreased body ratio, spleen and thymus weights as well as regulation of hematopoietic parameter including white blood cell, lymphocyte, and neutrophil. According to histological study, AGN regenerated on CP-mediated injured spleen. Moreover, AGN increased the CP-induced reduction of cytokine expression in spleen tissue. Collectively, the findings provide experimental evidence that AGN may be a candidate for health-improving herbs.

키워드

참고문헌

  1. Basha S, Surendran N, Pichichero M. Immune responses in neonates. Expert Review of Clinical Immunology. 2014. 10: 1171-1184. https://doi.org/10.1586/1744666X.2014.942288
  2. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradely A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 1993. 259: 1739-1742. https://doi.org/10.1126/science.8456300
  3. Delves PJ, Roitt IM. The immune system. New England Journal of Medicine. 2000. 343: 37-49. https://doi.org/10.1056/NEJM200007063430107
  4. De Souza C, Santini G, Marino G, Nati S, Congiu A, Vigorito A, Damasio E. Amifostine (WR-2721), a cytoprotective agent during high-dose cyclophosphamide treatment of non-Hodgkin's lymphomas: a phase II study. Brazilian Journal of Medical and Biological Research. 2000. 33: 791-798. https://doi.org/10.1590/S0100-879X2000000700009
  5. Gladstone D, Prestrud A, Pradhan A, Styler M, Topolsky D, Crilley P, Hoch S, Huppert A, Brodsky I. High-dose cyclophosphamide for severe systemic lupus erythematosus. Lupus. 2002. 11: 405-410. https://doi.org/10.1191/0961203302lu229oa
  6. Hoffman W, Lakkis FG, Chalasani G. B cells, antibodies, and more. Clinical Journal of the American Society of Nephrology. 2016. 11: 137-154. https://doi.org/10.2215/cjn.09430915
  7. Huitema AD, Smits KD, Mathot RA, Schellens JH, Rodenhuis S, Beijnen JH. The clinical pharmacology of alkylating agents in high-dose chemotherapy. Anti-Cancer Drugs. 2000. 11: 515-533. https://doi.org/10.1097/00001813-200008000-00002
  8. Jiang MH, Zhu L, Jiang JG. Immunoregulatory actions of polysaccharides from Chinese herbal medicine. Expert Opinion on Therapetic Targets. 2010. 14: 1367-1402. https://doi.org/10.1517/14728222.2010.531010
  9. Kim EY, Baik IH, Kim JH, Kim SR, Rhyu MR. Screening of the antioxidant activity of some medicinal plants. Korean Journal of Food Science and Technology. 2004. 36: 333-338.
  10. Kim KM, Jung JY, Hwang SW, Kim MJ, Kang JS. Isolation and purification of decursin and decursinol angelate in Angelica gigas Nakai. Journal of the Korean Society of Food Science and Nutrition. 2009. 38: 653-656. https://doi.org/10.3746/JKFN.2009.38.5.653
  11. Kumar SK, Bhat BV. Distinct mechanisms of the newborn innate immunity. Immunology Letters. 2016. 173: 42-54. https://doi.org/10.1016/j.imlet.2016.03.009
  12. Lee HJ, Lee HJ, Lee EO, Lee JH, Lee KS, Kim KH, Kim SH, Lu J. In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin. The American Journal of Chinese Medicine. 2009. 37: 127-142. https://doi.org/10.1142/S0192415X09006722
  13. Logani MK, Alekseev S, Bhopale MK, Slovinsky WS, Ziskin MC. Effect of millimeter waves and cyclophosphamide on cytokine regulation. Immunopharmacology and Immunotoxicology 2012. 34: 107-112. https://doi.org/10.3109/08923973.2011.583252
  14. Nathaniel D, George P, Weinkove R. Chimeric antigen receptor T-cell therapies: Optimising the dose. The British Journal of Clinical Pharmacology. 2020. 86: 1678-1689. https://doi.org/10.1111/bcp.14281
  15. Park KW, Choi SR, Shon ME, Jeong IY, Kang KS, Lee ST, Shim KH, Seo KI. Cytotoxic effects of decursin from Angelica gigas Nakai in human cancer cells. Journal of the Korean Society of Food Science and Nutrition. 2007. 36: 1385-1390. https://doi.org/10.3746/JKFN.2007.36.11.1385
  16. Son CG, Han SH, Cho JH, Shin JW, Cho CH, Lee YW. Induction of hemopoiesis by saenghyuldan, a mixture of Ginseng radix, Paeoniae radix alba, and Hominis placenta extracts. Acta Pharmacologica Sinica. 2003. 24: 120-126.