Particle and aerosol research (한국입자에어로졸학회지)

Korean Association for Particle and Aerosol Research (한국입자에어로졸학회)
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Anti-bacterial properties and safety evaluation of disinfectant using Dendropanax morbifera (Hwangchil) extract for passenger cabin in the subway

지하철 객실 적용을 위한 황칠 추출물 소독제의 항균특성 및 안전성 평가

  • Received : 2022.02.04
  • Accepted : 2022.04.09
  • Published : 2022.06.30
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Abstract

Due to the syndrome coronavirus 2 (SARS-CoV-2) pandemic, the subway passenger cabin should be continuously sterilized. However, a disinfectant such as chlorine is toxic and can lead to different issues to human health. In this paper, we introduced a novel disinfectant based on natural product (Dendropanax morbifera extract). Via ultra-high performance liquid chromatography - mass spectrometer (UHPLC-MS), different compounds from Dendropanax morbifera extract showed antivirus potentials. Antimicrobial experiments confirmed that the air-disinfectant containing Dendropanax morbifera can eliminate harmful microorganisms including Gram (-), Gram (+), and yeast within 5 mins. The as-prepared air-disinfectant also showed high antivirus activity against H1N1, HRV, and EV71. Deodorization test also indicates that the as-prepared air-disinfectant can lower the harmful gas such as ammonia and trimethylamine in the atmosphere. To evaluate the potential of air-disinfectant containing Dendropanax morbifera in practical applications, different safety tests including acute oral toxicity, acute skin irritation, and eye irritation were conducted. Results showed that the as-prepared disinfectant did not negatively affect tested animals during these safety investigations.

Keywords

Acknowledgement

서울특별시 서울산업진흥원 <서울글로벌챌린지 2021> 사업을 통해 우수 논문으로 선정되어 작성된 논문이다.

References

  1. Abdelrahman, Z., Li, M., and Wang, X. (2020). Comparative review of SARS-CoV-2, SARS-CoV, MERS-cov, and Influenza A respiratory viruses. Frontiers in Immunology, 11, 552909. https://doi.org/10.3389/fimmu.2020.552909
  2. Astani, A., Navid, M.H., and Schnitzler, P. (2014). Attachment and penetration of acyclovir-resistant Herpes simplex virus are inhibited by Melissa officinalis extract. Phytotherapy Research, 28, 1547-1552. https://doi.org/10.1002/ptr.5166
  3. Astani, A., Reichling, J., and Schnitzler, P. (2012). Melissa officinalis extract inhibits attachment of Herpes simplex virus in vitro. Chemotherapy, 58, 70-77. https://doi.org/10.1159/000335590
  4. Chiow, K.H., Phoon, M.C., Putti, T., Tan, B.K.H., and Chow, V.T. (2016). Evaluation of antiviral activities of Houttuynia cordata Thunb. Extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pacific Journal of Tropical Medicine, 9, 1-7. https://doi.org/10.1016/j.apjtm.2015.12.002
  5. Ge, L., Wan, H., Tang, S., Chen, H., Li, J., Zhang, K., Zhou, B., Fei, J., Wu, S., and Zeng, X. (2018). Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. Flower buds exert pronounced anti-HBV activities. RSC Advances, 8, 35374-35385. https://doi.org/10.1039/c8ra07549b
  6. Hyun, T.K., Kim, M.O., Lee, H., Kim, Y., Kim, E., and Kim, J.S. (2013). Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera Leveille. Food Chemistry, 141, 1947-1955. https://doi.org/10.1016/j.foodchem.2013.05.021
  7. Kampf, G. (2018). Efficiacy of ethanol against viruses in hand disinfection. Journal of Hospital Infection 98, 331-338. https://doi.org/10.1016/j.jhin.2017.08.025
  8. Kim, R.-W., Lee, S.-Y., Kim, S.-G., Heo, Y.-R., Son, M.-K. (2016). Antimicrobial, antioxidant and cytotoxic activities of Dendropanax morbifera Leveille exract for mouthwash and denture cleaning solution. The Journal of Advanced Prosthodontics, 8, 172-180. https://doi.org/10.4047/jap.2016.8.3.172
  9. Knipping, K., Garssen, J., and van't Land, B. (2012). An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts. Virology Journal 2012 9:1, 9, 1-8. https://doi.org/10.1186/1743-422x-9-1
  10. Langland, J., Jacobs, B., Wagner, C.E., Ruiz, G., and Cahill, T.M. (2018). Antiviral activity of metal chelates of caffeic acid and similar compounds towards herpes simplex, VSV-Ebola pseudotyped and vaccinia viruses. Antiviral Research, 160, 143-150. https://doi.org/10.1016/j.antiviral.2018.10.021
  11. Li, Y.L., Ma, S.C., Yang, Y.T., Ye, S.M., and But, P.P.H. (2002). Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge. Journal of Ethnopharmacology, 79, 365-368. https://doi.org/10.1016/S0378-8741(01)00410-X
  12. Lin, C.-W., Tsai, F.-J., Tsai, C.-H., Lai, C.-C., Wan, L., Ho, T.-Y., Hsieh, C.-C., and Chao, P.-D.L. (2005). Anti-SARS coronavirus 3c-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Research, 68, 36-42. https://doi.org/10.1016/j.antiviral.2005.07.002
  13. Sauter, D., Schwarz, S., Wang, K., Zhang, R., Sun, B., and Schwarz, W. (2014). Genistein as antiviral drug against HIV ion channel. Planta medica, 80, 682-687. https://doi.org/10.1055/s-0034-1368583
  14. Schwarz, S., Sauter, D., Wang, K., Zhang, R., Sun, B., Karioti, A., Bilia, A.R., Efferth, T., and Schwarz, W. (2014). Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta medica, 80, 177-182. https://doi.org/10.1055/s-0033-1360277
  15. Sithisarn, P., Michaelis, M., Schubert-Zsilavecz, M., and Cinatl, J. (2013). Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin a and baicalein in H5N1 influenza a virus-infected cells. Antiviral Research, 97, 41-48. https://doi.org/10.1016/j.antiviral.2012.10.004
  16. Wang, G.F., Shi, L.P., Ren, Y.D., Liu, Q.F., Liu, H.F., Zhang, R.J., Li, Z., Zhu, F.H., He, P.L., Tang, W., Tao, P.Z., Li, C., Zhao, W.M., and Zuo, J.P. (2009). Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Research, 83, 186-190. https://doi.org/10.1016/j.antiviral.2009.05.002
  17. Yu, M.-S., Lee, J., Lee, J.M., Kim, Y., Chin, Y.-W., Jee, J.-G., Keum, Y.-S., and Jeong, Y.-J. (2012). Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorganic & Medicinal Chemistry Letters, 22, 4049-4054. https://doi.org/10.1016/j.bmcl.2012.04.081