과제정보
This work was supported by grants from the Next-Generation BioGreen 21 Program (PJ01344401) of the Rural Development Administration, and by R&D Program for Forest Science Technology (Project No. 2021339A00-2123-CD02) provided by Korea Forest Service (Korea Forestry Promotion Institute), Republic of Korea.
참고문헌
- Hostettmann KA, Marston A. Saponins. Chemistry and pharmacology of natural products. Cambridge: United Kingdom: Cambridge University Press; 1995.
- Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 1999;55:567-75. https://doi.org/10.1007/s002280050674
- Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci 2001;16:S28-37. https://doi.org/10.3346/jkms.2001.16.s.s28
- Han JY, Kwon YS, Yang DC, Jung YR, Choi YE. Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng. Plant Cell Physiol 2006;47:1653-62. https://doi.org/10.1093/pcp/pcl032
- Han JY, Kim HJ, Kwon YS, Choi YE. The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol 2011;52:2062-73. https://doi.org/10.1093/pcp/pcr150
- Han JY, Hwang HS, Choi SW, Kim HJ, Choi YE. Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol 2012;53:1535-45. https://doi.org/10.1093/pcp/pcs106
- Yan X, Fan Y, Wei W, Wang P, Liu Q, Wei Y, Zhang L, Zhao G, Yue J, Zhou Z. Production of bioactive ginsenoside compound K in metabolically engineered yeast. Cell Res 2014;24:770-3. https://doi.org/10.1038/cr.2014.28
- Mao Q, Zhang PH, Wang Q, Li SL. Ginsenoside F2 induces apoptosis in humor gastric carcinoma cells through reactive oxygen species-mitochondria pathway and modulation of ASK-1/JNK signaling cascade in vitro and in vivo. Phytomedicine 2014;21(4):515-22. https://doi.org/10.1016/j.phymed.2013.10.013
- Ahuja A, Kim JH, Yi YS, Cho JY. Functional role of ginseng-derived compounds in cancer. J Ginseng Res 2018;42(3):248-54. https://doi.org/10.1016/j.jgr.2017.04.009
- Jin J, Shahi S, Kang HK, van Veen HW, Fan T-P. Metabolites of ginsenosides as novel BCRP inhibitors. Biochem Biophys Res Commun 2006;345(4):1308-14. https://doi.org/10.1016/j.bbrc.2006.04.152
- Shim SH, Baek K-H, Kim YS. Inhibition of human 20S proteasome by ginsenosides from Panax ginseng. Bull Korean Chem Soc 2009;30:1385-7. https://doi.org/10.5012/bkcs.2009.30.6.1385
- Lee JI, Ha YW, Choi TW, et al. Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells. Planta Med 2011;77(2):133-40. https://doi.org/10.1055/s-0030-1250160
- Chen XJ, Zhang XJ, Shui YM, Wan JB, Gao JL. Anticancer activities of protopanaxadiol- and protopanaxatriol-type ginsenosides and their metabolites. Evid-Based Complement Altern Med 2016;2016:1-19.
- Helms S. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev 2004;9:259-74.
- Wang M, Li H, Liu W, Cao H, Hu X, Gao X, Xu F, Li Z, Hua H, Li D. Dammarane-type leads panaxadiol and protopanaxadiol for drug discovery: biological activity and structural modification. Eur J Med Chem 2020;189:112087. https://doi.org/10.1016/j.ejmech.2020.112087
- Begemann MB, Gray BN, January E, Gordon GC, He Y, Liu H, Wu X, Brutnell TP, Mockler TC, Oufattole M. Precise insertion and guided editing of higher plant genomes using Cpf1 CRISPR nucleases. Sci Rep 2017;7:11606. https://doi.org/10.1038/s41598-017-11760-6
- Petolino JF, Srivastava V, Daniell H. Editing Plant Genomes: a new era of crop improvement. Plant Biotechnol J 2016;14:435-6. https://doi.org/10.1111/pbi.12542
- Murashige T, Skoog F. A revised medium for rapid growth and bioassays with tobacco tissue. Physiol Plant 1962;15:473-97. https://doi.org/10.1111/j.1399-3054.1962.tb08052.x
- Kim JY, Adhikari PB, Ahn CH, Kim DH, Kim YC, Han JY, et al. High frequency somatic embryogenesis and plant regeneration of interspecific ginseng hybrid between Panax ginseng and Panax quinquefolius. J Ginseng Res 2019;43:38-48. https://doi.org/10.1016/j.jgr.2017.08.002
- Park J, Lim K, Kim JS, Bae S. Cas-analyzer: an online tool for assessing genome editing results using NGS data. Bioinformatics 2017;33:286-8. https://doi.org/10.1093/bioinformatics/btw561
- Choi HI, Waminal NE, Park HM, Kim NH, Choi BS, Park M, Choi D, Lim YP, Kwon SJ, Park BS, et al. Major repeat components covering one-third of the ginseng (Panax ginseng C.A. Meyer) genome and evidence for allotetraploidy. Plant J 2014;77:906-16. https://doi.org/10.1111/tpj.12441
- Jayakodi M, Choi BS, Lee SC, Kim NH, Park JY, Jang W, et al. Ginseng Genome Database: an open-access platform for genomics of Panax ginseng. BMC Plant Biology 2018;18:62. https://doi.org/10.1186/s12870-018-1282-9
- Bae S, Park J, Kim JS. Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases. Bioinformatics 2014;30:1473-5. https://doi.org/10.1093/bioinformatics/btu048
- Choi HW, Koo DH, Bang KH, Paek KY, Seong NS, Bang JW. FISH and GISH analysis of the genomic relationships among Panax species. Genes Genom 2009;31:99-105. https://doi.org/10.1007/BF03191143
- Park SB, Chun JH, Ban YW, Han JY, Choi YE. Alteration of Panax ginseng saponin composition by overexpression and RNA interference of the protopanaxadiol 6-hydroxylase gene (CYP716A53v2). J Ginseng Res 2016;40:47-54. https://doi.org/10.1016/j.jgr.2015.04.010