Acknowledgement
This work was supported by the National Research Foundation, funded by the Korean government (Ministry of Science and ICT; NRF-2022R1C1C2003113).
References
- Choe, S.S., Huh, J.Y., Hwang, I.J., Kim, J.I., and Kim, J.B. (2016). Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front. Endocrinol. (Lausanne) 7, 30. https://doi.org/10.3389/fendo.2016.00030
- Emont, M.P., Jacobs, C., Essene, A.L., Pant, D., Tenen, D., Colleluori, G., Di Vincenzo, A., Jorgensen, A.M., Dashti, H., Stefek, A., et al. (2022). A singlecell atlas of human and mouse white adipose tissue. Nature 603, 926-933. https://doi.org/10.1038/s41586-022-04518-2
- Hwang, I. and Kim, J.B. (2019). Two faces of white adipose tissue with heterogeneous adipogenic progenitors. Diabetes Metab. J. 43, 752-762. https://doi.org/10.4093/dmj.2019.0174
- Jaitin, D.A., Adlung, L., Thaiss, C.A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019). Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner. Cell 178, 686-698.e14. https://doi.org/10.1016/j.cell.2019.05.054
- Kim, J.I., Park, J., Ji, Y., Jo, K., Han, S.M., Sohn, J.H., Shin, K.C., Han, J.S., Jeon, Y.G., Nahmgoong, H., et al. (2019). During adipocyte remodeling, lipid droplet configurations regulate insulin sensitivity through F-actin and G-actin reorganization. Mol. Cell. Biol. 39, e00210-19.
- Lee, S., Kim, J., and Park, J.E. (2021). Single-cell toolkits opening a new era for cell engineering. Mol. Cells 44, 127-135. https://doi.org/10.14348/molcells.2021.0002
- Nahmgoong, H., Jeon, Y.G., Park, E.S., Choi, Y.H., Han, S.M., Park, J., Ji, Y., Sohn, J.H., Han, J.S., Kim, Y.Y., et al. (2022). Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics. Cell Metab. 34, 458-472.e6. https://doi.org/10.1016/j.cmet.2021.11.014
- Rosen, E.D. and Spiegelman, B.M. (2014). What we talk about when we talk about fat. Cell 156, 20-44. https://doi.org/10.1016/j.cell.2013.12.012
- Sarvari, A.K., Van Hauwaert, E.L., Markussen, L.K., Gammelmark, E., Marcher, A.B., Ebbesen, M.F., Nielsen, R., Brewer, J.R., Madsen, J.G.S., and Mandrup, S. (2021). Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution. Cell Metab. 33, 437-453.e5. https://doi.org/10.1016/j.cmet.2020.12.004