Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton

  • Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Tjahjandarie, Tjitjik Srie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Mardhiyyah, Shola (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Rahman, Ghinsha Zakatina (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Aldin, Muhammad Fajar (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Saputri, Ratih Dewi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya) ;
  • Ahmat, Norizan (Faculty of Applied Sciences, Universiti Teknologi MARA)
  • Received : 2022.02.24
  • Accepted : 2022.03.25
  • Published : 2022.06.30
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Abstract

Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1 - 3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 μM.

Keywords

Acknowledgement

Universitas Airlangga, Surabaya, Indonesia, provided financial assistance for this research (Penelitian Dasar Unggulan Perguruan Tinggi, No. 468/UN3.15/PT/2021 by Mulyadi Tanjung).

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