Parasites, Hosts and Diseases

  • 제60권3호
  • /
  • Pages.181-185
  • /
  • 2022
  • /
  • 2982-5164(pISSN)
  • /
  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
권호 표지
DOI QR코드

DOI QR Code

Seropositivity Rates of Strongyloides stercoralis Antibody in the Southeastern Region of Republic of Korea: A Single-Center Retrospective Study

  • Kim, Taehwa (Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital) ;
  • Lim, Seungjin (Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital)
  • 투고 : 2022.04.29
  • 심사 : 2022.05.26
  • 발행 : 2022.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Strongyloides stercoralis infection is not endemic in the Republic of Korea (Korea) with a positivity rate of <1% in stool examination. However, there is a risk of hyperinfection in immunosuppressed individuals. It is necessary to determine the seropositivity of S. stercoralis antibodies in Korea. This study investigated the seropositivity of S. stercoralis antibodies in the southeastern area of Korea. From January 2019 to June 2021, serum samples were collected from participants who visited the study center in the southeastern region of Korea for routine health check-ups. We determined serum levels of specific anti-Strongyloides IgG antibodies in 834 samples by enzyme-linked immunosorbent assay. We observed that 92 samples (11.0%) tested showed a positive response. The age of the participants was 51±10.7 years, and 43.4% of them were men. The antibody positivity rate based on the location of the participants' residence were 12.3% (Gyoungsangnam-do), 10.2% (Busan), and 10.1% (Ulsan), respectively. Total eosinophil count was associated with positive test results (154.8±152.0 per mm3 versus 202.1±178.9 per mm3, P=0.006). Logistic regression analysis revealed that blood eosinophil count, age above 50 years, and residence in Sacheon were factors associated with the positive status of S. stercoralis antibody. Our finding suggests that it is necessary to test for S. stercoralis in actual clinical settings in Korea.

키워드

과제정보

The biospecimens and data used in this study were provided by the Human Material Bank of the Pusan National University Yangsan Hospital. This study was supported by Research institute for Convergence of biomedical science and technology, Pusan National University Yangsan Hospital grant number: Incubating Task Research Support 2020.

참고문헌

  1. Viney ME, Lok JB. Strongyloides spp. In Hodgkin J, Anderson Peds, WormBook eds, The C. elegans Research Community, WormBook. 2007, pp 1-15. https://doi/10.1895/wormbook.1.141.1
  2. Winnicki W, Eder M, Mazal P, Mayer FJ, Sengolge G, Wagner L. Prevalence of Strongyloides stercoralis infection and hyperinfection syndrome among renal allograft recipients in Central Europe. Sci Rep 2018; 8: 15406. https://doi.org/10.1038/s41598-018-33775-3
  3. Park K, Kim MS, Chang J, Kim EJ, Yoo C, Kim MJ, Sung H, Kim MN. A case of chronic strongyloidiasis with recurrent hyperinfection. Lab Med Online 2019; 9: 171-176 (in Korean). https://doi.org/10.3343/lmo.2019.9.3.171
  4. Keiser PB, Nutman TB. Strongyloides stercoralis in the immunocompromised population. Clin Microbiol Rev 2004; 17: 208-217. https://doi.org/10.1128/CMR.17.1.208-217.2004
  5. Kim J, Joo HS, Kim DH, Lim H, Kang YH, Kim MS. A case of gastric strongyloidiasis in a Korean patient. Korean J Parasitol 2003; 41: 63-67. https://doi.org/10.3347/kjp.2003.41.1.63
  6. Kim J, Joo HS, Ko HM, Na MS, Hwang SH, Im JC. A case of fatal hyperinfective strongyloidiasis with discovery of autoinfective filariform larvae in sputum. Korean J Parasitol 2005; 43: 51-55. https://doi.org/10.3347/kjp.2005.43.2.51
  7. Cho JY, Kwon JG, Ha KH, Oh JY, Jin MI, Heo SW, Lee GH, Cho CH. A case of steroid-induced hyperinfective strongyloidiasis with bacterial meningitis. Korean J Gastroenterol 2012; 60: 330-334 (in Korean). https://doi.org/10.4166/kjg.2012.60.5.330
  8. Rah YM, Yun SA, Yoon HJ, Lee SY. Strongyloides hyperinfection in an elderly patient treated for stomach cancer. Ann Geriatr Med Res 2014; 18: 241-245 (in Korean). https://doi.org/10.4235/jkgs.2014.18.4.241
  9. Seo AN, Goo YK, Chung DI, Hong Y, Kwon O, Bae HI. Comorbid gastric adenocarcinoma and gastric and duodenal Strongyloides stercoralis infection: a case report. Korean J Parasitol 2015; 53: 95-99. https://doi.org/10.3347/kjp.2015.53.1.95
  10. Won EJ, Jeon J, Koh YI, Ryang DW. Strongyloidiasis in a diabetic patient accompanied by gastrointestinal stromal tumor: cause of eosinophilia unresponsive to steroid therapy. Korean J Parasitol 2015; 53: 223-226. https://doi.org/10.3347/kjp.2015.53.2.223
  11. Kim JH, Kim DS, Yoon YK, Sohn JW, Kim MJ. Donor-derived strongyloidiasis infection in solid organ transplant recipients: a review and pooled analysis. Transplant Proc 2016; 48: 2442-2449. https://doi.org/10.1016/j.transproceed.2015.11.045
  12. Kim EJ. Acute respiratory distress syndrome with alveolar hemorrhage due to strongyloidiasis hyperinfection in an older patient. Ann Geriatr Med Res 2018; 22: 200-203. https://doi.org/10.4235/agmr.18.0041
  13. Ra H, Chung JW, Chung DH, Kim JH, Kim YJ, Kim KO, Kwon KA, Park DK. Strongyloidiasis presenting as yellowish nodules in colonoscopy of an immunocompetent patient. Clin Endosc 2019; 52: 80-82. https://doi.org/10.5946/ce.2018.078
  14. Bae J, Jeong MJ, Shin DH, Kim HW, Ahn SH, Choi JH, Yu HS. Phylogenetic positioning of a Strongyloides stercoralis isolate recovered from a Korean patient and comparison with other Asian isolates. Korean J Parasitol 2020; 58: 689-694. https://doi.org/10.3347/kjp.2020.58.6.689
  15. Youn H. Review of zoonotic parasites in medical and veterinary fields in the Republic of Korea. Korean J Parasitol 2009; 47 (suppl): 133-141. https://10.3347/kjp.2009.47.S.S133
  16. Buonfrate D, Bisanzio D, Giorli G, Odermatt P, Furst T, Greenaway C, French M, Reithinger R, Gobbi F, Montresor A, Bisoffi Z. The global prevalence of Strongyloides stercoralis infection. Pathogens 2020; 9: 468. https://doi.org/10.3390/pathogens9060468
  17. Bisoff Z, Buonfrate D, Sequi M, Mejia R, Cimino RO, Krolewiecki AJ, Albonico M, Gobbo M, Bonafini S, Angheben A, Requena-Mendez A. Diagnostic accuracy of five serologic tests for Strongyloides stercoralis infection. PLoS Negl Trop Dis 2014; 8: e2640. https://doi.org/10.1371/journal.pntd.0002640
  18. Beck HE, Zimmermann NE, McVicar TR, Vergopolan N, Berg A, Wood EF. Present and future Koppen-Geiger climate classification maps at 1-km resolution. Sci Data 2018; 5: 180214. https://doi.org/10.1038/sdata.2018.214
  19. Statistical Geographic Information System. Population and household theme map list [Internet]. Available from: https://sgis.kostat.go.kr/view/thematicMap/thematicMapMain?stat_thema_map_id=sI8uqsnppF20160121115806975w5w92MFI5L&theme=CTGR_001&mapType=05&CTGRS=CTGR_001:recommend,CTGR_002:recommend,CTGR_003:recommend,CTGR_004:recommend,CTGR_005:recommend,CTGR_006:recommend (in Korean).
  20. Suntaravitun P, Dokmaikaw A. Prevalence of intestinal parasites and associated risk factors for infection among rural communities of Chachoengsao Province, Thailand. Korean J Parasitol 2018; 56: 33-39. https://doi.org/10.3347/kjp.2018.56.1.33
  21. Kobayashi J, Sato Y, Toma H, Shimabukuro I, Tasaki T, Takara M, Shiroma Y. Epidemiological features of strongyloides infection in Okinawa, Japan: comparative study with other endemic areas. Jpn J Trop Med Hyg 2000; 28: 9-14. https://doi.org/10.2149/tmh1973.28.9
  22. Zhou X, James AA, Wang C, Li J, Chen X, Yan G, Xu J. Strongyloidiasis: an emerging infectious disease in China. Am J Trop Med Hyg 2013; 88: 420-425. https://doi.org/10.4269/ajtmh.12-0596
  23. Mirzaei L, Ashrafi K, Roushan ZA, Mahmoudi MR, Masooleh IS, Rahmati B, Saadat F, Mirjalali H, Sharifdini M. Strongyloides stercoralis and other intestinal parasites in patients receiving immunosuppressive drugs in northern Iran: a closer look at risk factors. Epidemiol Health 2021; 43: e2021009. https://doi.org/10.4178/epih.e2021009
  24. Statistical Geographic Information System. Number of agricultural workers 2020 [Internet]. Available from: https://sgis.kostat.go.kr/view/thematicMap/thematicMapMain?stat_thema_map_id=JouDrDrEIF201601211158069886Mv8uqz22x&theme=CTGR_004&mapType=05&CTGRS=CTGR_001:recommend,CTGR_002:recommend,CTGR_003:recommend,CTGR_004:recommend,CTGR_005:recommend,CTGR_006:recommend (in Korean).