Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

Potential Role of Bioactive Phytochemicals in Combination Therapies against Antimicrobial Activity

  • Received : 2020.11.05
  • Accepted : 2022.02.08
  • Published : 2022.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Since ancient times, plants have been a major source of novel drug molecules and have been used in the treatment of different infectious diseases. Secondary plant metabolites have miraculous healing properties and show potent therapeutic responses when used in combination drug therapy. The prime objective of this review is to summarize the concept of drug combination with special emphasis on the synergistic interactions between plant-derived bioactive phytochemicals with commercially available antimicrobial agents. The study also assesses the roles, importance, and applicability of phytochemicals in the management of different diseases. The review focuses on different aspects of combined antimicrobial activities, the possible mechanisms involved, and the current status of research in the field. The study was conducted based on an extensive literature survey that resulted in the following hypothesis: secondary metabolites derived from plants possess remarkable therapeutic activities. The study was designed as a systematic review that ensures unbiased and accurate representations of the relevant data and information. Jadad scale selection criteria were used for qualitative analysis of the articles to assess them based on the relevant secure score (minimum and maximum scores range between 1 and 5, respectively). Articles with secure scores > 3 were considered for the study. A comprehensive literature survey was conducted using resource databases including PubMed, Google Scholar, Bielefeld Academic Search Engine, Research Gate, Scopus, Medline, and Science Direct up to June 2019. This article contains concise information about the most commonly used bioactive phytochemicals with potent antifungal and antibacterial effects.

Keywords

Acknowledgement

Author would like to acknowledge the management of the Faculty of Pharmaceutical Science, Assam down town University for providing essential facilities and support to complete the study.

References

  1. Ulrich-Merzenich G, Panek D, Zeitler H, Vetter H, Wagner H. Drug development from natural products: exploiting synergistic effects. Indian J Exp Biol. 2010;48(3):208-19.
  2. Calixto JB. The role of natural products in modern drug discovery. Ann Braz Acad Sci. 2019;91(Suppl 3):e20190105. https://doi.org/10.1590/0001-3765201920190105
  3. Hemaiswarya S, Kruthiventi AK, Doble M. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine. 2008;15(8):639-52. https://doi.org/10.1016/j.phymed.2008.06.008
  4. Ma XH, Zheng CJ, Han LY, Xie B, Jia J, Cao ZW, et al. Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. Drug Discov Today. 2009;14(11-12):579-88. https://doi.org/10.1016/j.drudis.2009.03.012
  5. Rani A, Jain S, Dureja P, Kumar R, Kumar A. Synergistic interaction between synthetic and natural products: a promising tool for the development of environmentally safe potent antimicrobial agents. World Appl Sci J. 2009;5:59-63.
  6. Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem. 2014;6:25-64. https://doi.org/10.4137/pmc.s14459
  7. Roy A, Choudhury A, Bahadur S, Saha S. Phytoconstituent based mucoadhesive antifungal vaginal formulation: an effective and innovative approach. Biosci Biotechnol Res Commun. 2016;9(4):694-701. https://doi.org/10.21786/bbrc/9.4/17
  8. Tamma PD, Cosgrove SE, Maragakis LL. Combination therapy for treatment of infections with gram-negative bacteria. Clin Microbiol Rev. 2012;25(3):450-70. https://doi.org/10.1128/CMR.05041-11
  9. Nigam A, Gupta D, Sharma A. Treatment of infectious disease: beyond antibiotics. Microbiol Res. 2014;169(9-10):643-51. https://doi.org/10.1016/j.micres.2014.02.009
  10. Wagner H, Ulrich-Merzenich G. Synergy research: approaching a new generation of phytopharmaceuticals. J Nat Remedies. 2009;9(2):121-41.
  11. Tallarida RJ. Drug synergism: its detection and applications. J Pharmacol Exp Ther. 2001;298(3):865-72.
  12. Chen D, Liu X, Yang Y, Yang H, Lu P. Systematic synergy modeling: understanding drug synergy from a systems biology perspective. BMC Syst Biol. 2015;9:56. https://doi.org/10.1186/s12918-015-0202-y
  13. Tsao SM, Yin MC. Enhanced inhibitory effect from interaction of curcumin with amphotericin B or fluconazole against Candida species. J Food Drug Anal. 2000;8(3):208-12.
  14. Chung I, Kwon SH, Shim ST, Kyung KH. Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic. J Food Sci. 2007;72(9):M437-40.
  15. Amenu D. Antimicrobial activity of medicinal plant extracts and their synergistic effect on some selected pathogens. Am J Ethnomed. 2014;1(1):18-29.
  16. Rabadia A, Kamat S, Kamat D. Antifungal activity of essential oils against fluconazole resistant fungi. Int J Phytomed. 2011;3(4):506-10.
  17. Garcia-Gomes AS, Curvelo JA, Soares RM, Ferreira-Pereira A. Curcumin acts synergistically with fluconazole to sensitize a clinical isolate of Candida albicans showing a MDR phenotype. Med Mycol. 2012;50(1):26-32. https://doi.org/10.3109/13693786.2011.578156
  18. Pyun MS, Shin S. Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole. Phytomedicine. 2006;13(6):394-400. https://doi.org/10.1016/j.phymed.2005.03.011
  19. Faria NC, Kim JH, Goncalves LA, Martins Mde L, Chan KL, Campbell BC. Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus. Lett Appl Microbiol. 2011;52(5):506-13. https://doi.org/10.1111/j.1472-765X.2011.03032.x
  20. Canturk Z. Evaluation of synergistic anticandidal and apoptotic effects of ferulic acid and caspofungin against Candida albicans. J Food Drug Anal. 2018;26(1):439-43. https://doi.org/10.1016/j.jfda.2016.12.014
  21. Jayaraman P, Sakharkar MK, Lim CS, Tang TH, Sakharkar KR. Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro. Int J Biol Sci. 2010;6(6):556-68.
  22. Sudano Roccaro A, Blanco AR, Giuliano F, Rusciano D, Enea V. Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells. Antimicrob Agents Chemother. 2004;48(6):1968-73. https://doi.org/10.1128/AAC.48.6.1968-1973.2004
  23. Sakharkar MK, Jayaraman P, Soe WM, Chow VT, Sing LC, Sakharkar KR. In vitro combinations of antibiotics and phytochemicals against Pseudomonas aeruginosa. J Microbiol Immunol Infect. 2009;42(5):364-70.
  24. Liu MH, Otsuka N, Noyori K, Shiota S, Ogawa W, Kuroda T, et al. Synergistic effect of kaempferol glycosides purified from Laurus nobilis and fluoroquinolones on methicillin-resistant Staphylococcus aureus. Biol Pharm Bull. 2009;32(3):489-92. https://doi.org/10.1248/bpb.32.489
  25. Lewandowska U, Gorlach S, Owczarek K, Hrabec E, Szewczyk K. Synergistic interactions between anticancer chemotherapeutics and phenolic compounds and anticancer synergy between polyphenols. Postepy Hig Med Dosw (Online). 2014;68:528-40. https://doi.org/10.5604/17322693.1102278
  26. Zhu Y, He W, Gao X, Li B, Mei C, Xu R, et al. Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells. Sci Rep. 2015;5:17730. https://doi.org/10.1038/srep17730
  27. de Oliveira DR, Tintino SR, Braga MF, Boligon AA, Athayde ML, Coutinho HD, et al. In vitro antimicrobial and modulatory activity of the natural products silymarin and silibinin. Biomed Res Int. 2015;2015:292797. https://doi.org/10.1155/2015/292797
  28. de Andrade Neto JB, da Silva CR, de Sousa Campos R, Nascimento FBSA, Sampaio LS, da Silva AR, et al. Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole against strains of fluconazole-resistant Candida parapsilosis. Int J Curr Microbiol App Sci. 2015;4(5):68-79.
  29. Liu W, Li LP, Zhang JD, Li Q, Shen H, Chen SM, et al. Synergistic antifungal effect of glabridin and fluconazole. PLoS One. 2014;9(7):e103442. https://doi.org/10.1371/journal.pone.0103442
  30. Kobayashi T, Kakeya H, Miyazaki T, Izumikawa K, Yanagihara K, Ohno H, et al. Synergistic antifungal effect of lactoferrin with azole antifungals against Candida albicans and a proposal for a new treatment method for invasive candidiasis. Jpn J Infect Dis. 2011;64(4):292-6. https://doi.org/10.7883/yoken.64.292
  31. Ettayebi K, El Yamani J, Rossi-Hassani B. Synergistic effects of nisin and thymol on antimicrobial activities in Listeria monocytogenes and Bacillus subtilis. FEMS Microbiol Lett. 2000;183(1):191-5. https://doi.org/10.1016/S0378-1097(99)00665-5
  32. Reuk-ngam N, Chimnoi N, Khunnawutmanotham N, Techasakul S. Antimicrobial activity of coronarin D and its synergistic potential with antibiotics. Biomed Res Int. 2014;2014:581985. https://doi.org/10.1155/2014/581985
  33. Cojocneanu Petric R, Braicu C, Raduly L, Zanoaga O, Dragos N, Monroig P, et al. Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers. Onco Targets Ther. 2015;8:2053-66.
  34. Aiyegoro OA, Okoh A. Use of bioactive plant products in combination with standard antibiotics: Implications in antimicrobial chemotherapy. J Med Plants Res. 2009;3(13):1147-52.
  35. Wei Y, Yang P, Cao S, Zhao L. The combination of curcumin and 5-fluorouracil in cancer therapy. Arch Pharm Res. 2018;41(1):1-13. https://doi.org/10.1007/s12272-017-0979-x
  36. Sopirala MM, Mangino JE, Gebreyes WA, Biller B, Bannerman T, Balada-Llasat JM, et al. Synergy testing by Etest, microdilution checkerboard, and time-kill methods for pan-drug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2010;54(11):4678-83. https://doi.org/10.1128/AAC.00497-10
  37. Orhan G, Bayram A, Zer Y, Balci I. Synergy tests by E test and checkerboard methods of antimicrobial combinations against Brucella melitensis. J Clin Microbiol. 2005;43(1):140-3. https://doi.org/10.1128/JCM.43.1.140-143.2005
  38. Balouiri M, Sadiki M, Ibnsouda SK. Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal. 2016;6(2):71-9. https://doi.org/10.1016/j.jpha.2015.11.005