Korean Journal of Radiology

  • 제23권4호
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  • Pages.455-465
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  • 2022
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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Comparative Study between ZOOMit and Conventional Intravoxel Incoherent Motion MRI for Assessing Parotid Gland Abnormalities in Patients with Early- or Mid-Stage Sjögren's Syndrome

  • Qing-Qing Zhou (Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University) ;
  • Wei Zhang (Department of Immunology and Rheumatology, The Affiliated Jiangning Hospital of Nanjing Medical University) ;
  • Yu-Sheng Yu (Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University) ;
  • Hong-Yan Li (Department of Immunology and Rheumatology, The Affiliated Jiangning Hospital of Nanjing Medical University) ;
  • Liang Wei (Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University) ;
  • Xue-Song Li (Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University) ;
  • Zhen-Zhen He (Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University) ;
  • Hong Zhang (Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University)
  • 투고 : 2021.09.02
  • 심사 : 2021.12.27
  • 발행 : 2022.04.01
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초록

Objective: To compare the reproducibility and performance of quantitative metrics between ZOOMit and conventional intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) in the diagnosis of early- and mid-stage Sjögren's syndrome (SS). Materials and Methods: Twenty-two patients (mean age ± standard deviation, 52.0 ± 10.8 years; male:female, 2:20) with early- or mid-stage SS and 20 healthy controls (46.9 ± 14.6 years; male:female, 7:13) were prospectively enrolled in our study. ZOOMit IVIM and conventional IVIM MRI were performed simultaneously in all individuals using a 3T scanner. Quantitative IVIM parameters - including tissue diffusivity (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) - inter- and intra-observer reproducibility in measuring these parameters, and their ability to distinguish patients with SS from healthy individuals were assessed and compared between ZOOMit IVIM and conventional IVIM methods, appropriately. MR gland nodular grade (MRG) was also examined. Results: Inter- and intra-observer reproducibility was better with ZOOMit imaging than with conventional IVIM imaging (ZOOMit vs. conventional, intraclass correlation coefficient of 0.897-0.941 vs. 0.667-0.782 for inter-observer reproducibility and 0.891-0.968 vs. 0.814-0.853 for intra-observer reproducibility). Significant differences in ZOOMit f, ZOOMit D*, D*, conventional D*, and MRG between patients with SS and healthy individuals (all p < 0.05) were observed. ZOOMit D* outperformed conventional D* in diagnosing early- and mid-stage SS (area under receiver operating curve, 0.867 and 0.658, respectively; p = 0.002). The combination of ZOOMit D*, MRG, and ZOOMit f as a new diagnostic index for SS, increased diagnostic area under the curve to 0.961, which was higher than that of any single parameter (all p < 0.01). Conclusion: Considering its better reproducibility and performance, ZOOMit IVIM may be preferred over conventional IVIM MRI, and may subsequently improve the ability to diagnose early- and mid-stage SS.

키워드

과제정보

This work was supported by Science and Technology Development Fund project of Nanjing Medical University (NMUB2020166), the Key Project of Jiangning Hospital Youth Innovation Research (JNYYZXKY202022) and Jiangning District Science and Technology Benefit People Project (20212021NJNQKJHMJHXM0133).

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