Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Differential Diagnosis of Thick Myocardium according to Histologic Features Revealed by Multiparametric Cardiac Magnetic Resonance Imaging

  • Min Jae Cha (Department of Radiology, Chung-Ang University Hospital) ;
  • Cherry Kim (Department of Radiology, Korea University Ansan Hospital) ;
  • Chan Ho Park (Department of Radiology, Soonchunhyang University Cheonan Hospital) ;
  • Yoo Jin Hong (Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine) ;
  • Jae Min Shin (Department of Radiology and Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Tae Hoon Kim (Department of Radiology and Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Yoon Jin Cha (Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Chul Hwan Park (Department of Radiology and Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • Received : 2021.10.25
  • Accepted : 2022.02.27
  • Published : 2022.06.01
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Abstract

Left ventricular (LV) wall thickening, or LV hypertrophy (LVH), is common and occurs in diverse conditions including hypertrophic cardiomyopathy (HCM), hypertensive heart disease, aortic valve stenosis, lysosomal storage disorders, cardiac amyloidosis, mitochondrial cardiomyopathy, sarcoidosis and athlete's heart. Cardiac magnetic resonance (CMR) imaging provides various tissue contrasts and characteristics that reflect histological changes in the myocardium, such as cellular hypertrophy, cardiomyocyte disarray, interstitial fibrosis, extracellular accumulation of insoluble proteins, intracellular accumulation of fat, and intracellular vacuolar changes. Therefore, CMR imaging may be beneficial in establishing a differential diagnosis of LVH. Although various diseases share LV wall thickening as a common feature, the histologic changes that underscore each disease are distinct. This review focuses on CMR multiparametric myocardial analysis, which may provide clues for the differentiation of thickened myocardium based on the histologic features of HCM and its phenocopies.

Keywords

Acknowledgement

The authors wish to thank Ms. Inseon Park for all artistic support related to this work.

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