DOI QR코드

DOI QR Code

Direction of Tissue Contraction after Microwave Ablation: A Comparative Experimental Study in Ex Vivo Bovine Liver

  • Junhyok Lee (Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University) ;
  • Hyunchul Rhim (Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University) ;
  • Min Woo Lee (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Tae Wook Kang (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kyoung Doo Song (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jeong Kyong Lee (Department of Radiology, Mokdong Hospital, Ewha Womans University, School of Medicine)
  • 투고 : 2020.05.03
  • 심사 : 2021.08.16
  • 발행 : 2022.01.01

초록

Objective: This study aimed to investigate the direction of tissue contraction after microwave ablation in ex vivo bovine liver models. Materials and Methods: Ablation procedures were conducted in a total of 90 sites in ex vivo bovine liver models, including the surface (n = 60) and parenchyma (n = 30), to examine the direction of contraction of the tissue in the peripheral and central regions from the microwave antenna. Three commercially available 2.45-GHz microwave systems (Emprint, Neuwave, and Surblate) were used. For surface ablation, the lengths of two overlapped square markers were measured after 2.5- and 5-minutes ablations (n = 10 ablations for each system for each ablation time). For parenchyma ablation, seven predetermined distances between the markers were measured on the cutting plane after 5- and 10-minutes ablations (n = 5 ablations for each system for each ablation time). The contraction in the radial and longitudinal directions and the sphericity index (SI) of the ablation zones were compared between the three systems using analysis of variance. Results: In the surface ablation experiment, the mean longitudinal contraction ratio and SI from a 5-minutes ablation using the Emprint, Neuwave, and Surblate systems were 28.92% and 1.04, 20.10% and 0.53, and 24.90% and 0.45, respectively (p < 0.001). A positive correlation between longitudinal contraction and SI was noted, and a similar radial contraction was observed. In the parenchyma ablation experiment, the mean longitudinal contraction ratio and SI from a 10-minutes ablation using the three pieces of equipment were 38.60% and 1.06, 32.45% and 0.61, and 28.50% and 0.50, respectively (p < 0.001). There was a significant difference in the longitudinal contraction properties, whereas there was no significant difference in the radial contraction properties. Conclusion: The degree of longitudinal contraction showed significant differences depending on the microwave ablation equipment, which may affect the SI of the ablation zone.

키워드

과제정보

We thank Dong Un Kim, B.S. (Korea) for his technical assistance in the ex-vivo experiment.

참고문헌

  1. Lee JK, Siripongsakun S, Bahrami S, Raman SS, Sayre J, Lu DS. Microwave ablation of liver tumors: degree of tissue contraction as compared to RF ablation. Abdom Radiol (NY) 2016;41:659-666 https://doi.org/10.1007/s00261-016-0725-8
  2. Brace CL, Diaz TA, Hinshaw JL, Lee FT Jr. Tissue contraction caused by radiofrequency and microwave ablation: a laboratory study in liver and lung. J Vasc Interv Radiol 2010;21:1280-1286 https://doi.org/10.1016/j.jvir.2010.02.038
  3. Sommer CM, Sommer SA, Mokry T, Gockner T, Gnutzmann D, Bellemann N, et al. Quantification of tissue shrinkage and dehydration caused by microwave ablation: experimental study in kidneys for the estimation of effective coagulation volume. J Vasc Interv Radiol 2013;24:1241-1248 https://doi.org/10.1016/j.jvir.2013.04.008
  4. Liu D, Brace CL. Evaluation of tissue deformation during radiofrequency and microwave ablation procedures: influence of output energy delivery. Med Phys 2019;46:4127-4134 https://doi.org/10.1002/mp.13688
  5. Farina L, Nissenbaum Y, Cavagnaro M, Goldberg SN. Tissue shrinkage in microwave thermal ablation: comparison of three commercial devices. Int J Hyperthermia 2018;34:382-391 https://doi.org/10.1080/02656736.2017.1362115
  6. Amabile C, Farina L, Lopresto V, Pinto R, Cassarino S, Tosoratti N, et al. Tissue shrinkage in microwave ablation of liver: an ex vivo predictive model. Int J Hyperthermia 2017;33:101-109 https://doi.org/10.1080/02656736.2016.1208292
  7. Rossmann C, Garrett-Mayer E, Rattay F, Haemmerich D. Dynamics of tissue shrinkage during ablative temperature exposures. Physiol Meas 2014;35:55-67 https://doi.org/10.1088/0967-3334/35/1/55
  8. Liu D, Brace CL. CT imaging during microwave ablation: analysis of spatial and temporal tissue contraction. Med Phys 2014;41:113303
  9. Farina L, Weiss N, Nissenbaum Y, Cavagnaro M, Lopresto V, Pinto R, et al. Characterisation of tissue shrinkage during microwave thermal ablation. Int J Hyperthermia 2014;30:419-428 https://doi.org/10.3109/02656736.2014.957250
  10. Kim C. Understanding the nuances of microwave ablation for more accurate post-treatment assessment. Future Oncol 2018;14:1755-1764 https://doi.org/10.2217/fon-2017-0736
  11. Lubner MG, Brace CL, Hinshaw JL, Lee FT Jr. Microwave tumor ablation: mechanism of action, clinical results, and devices. J Vasc Interv Radiol 2010;21:S192-S203 https://doi.org/10.1016/j.jvir.2010.04.007
  12. Ruiter SJS, Heerink WJ, de Jong KP. Liver microwave ablation: a systematic review of various FDA-approved systems. Eur Radiol 2019;29:4026-4035 https://doi.org/10.1007/s00330-018-5842-z
  13. Fallahi H, Prakash P. Antenna designs for microwave tissue ablation. Crit Rev Biomed Eng 2018;46:495-521 https://doi.org/10.1615/CritRevBiomedEng.2018028554
  14. Alonzo M, Bos A, Bennett S, Ferral H. The emprintTM ablation system with thermosphereTM technology: one of the newer next-generation microwave ablation technologies. Semin Intervent Radiol 2015;32:335-338
  15. Vogl TJ, Basten LM, Nour-Eldin NA, Kaltenbach B, Bodelle B, Wichmann JL, et al. Evaluation of microwave ablation of liver malignancy with enabled constant spatial energy control to achieve a predictable spherical ablation zone. Int J Hyperthermia 2018;34:492-500 https://doi.org/10.1080/02656736.2017.1358408
  16. Weiss N, Goldberg SN, Nissenbaum Y, Sosna J, Azhari H. Planar strain analysis of liver undergoing microwave thermal ablation using x-ray CT. Med Phys 2015;42:372-380 https://doi.org/10.1118/1.4903896
  17. Lencioni R, de Baere T, Martin RC, Nutting CW, Narayanan G. Image-guided ablation of malignant liver tumors: recommendations for clinical validation of novel thermal and non-thermal technologies-a western perspective. Liver Cancer 2015;4:208-214 https://doi.org/10.1159/000367747
  18. Park MJ, Kim YS, Rhim H, Lim HK, Lee MW, Choi D. A comparison of US-guided percutaneous radiofrequency ablation of medium-sized hepatocellular carcinoma with a cluster electrode or a single electrode with a multiple overlapping ablation technique. J Vasc Interv Radiol 2011;22:771-779 https://doi.org/10.1016/j.jvir.2011.02.005
  19. Ierardi AM, Mangano A, Floridi C, Dionigi G, Biondi A, Duka E, et al. A new system of microwave ablation at 2450 MHz: preliminary experience. Updates Surg 2015;67:39-45 https://doi.org/10.1007/s13304-015-0288-1
  20. Hinshaw JL, Lubner MG, Ziemlewicz TJ, Lee FT Jr, Brace CL. Percutaneous tumor ablation tools: microwave, radiofrequency, or cryoablation--what should you use and why? Radiographics 2014;34:1344-1362 https://doi.org/10.1148/rg.345140054
  21. Brace CL. Microwave ablation technology: what every user should know. Curr Probl Diagn Radiol 2009;38:61-67 https://doi.org/10.1067/j.cpradiol.2007.08.011
  22. Brace CL. Radiofrequency and microwave ablation of the liver, lung, kidney, and bone: what are the differences? Curr Probl Diagn Radiol 2009;38:135-143 https://doi.org/10.1067/j.cpradiol.2007.10.001
  23. Brace CL. Microwave tissue ablation: biophysics, technology, and applications. Crit Rev Biomed Eng 2010;38:65-78 https://doi.org/10.1615/CritRevBiomedEng.v38.i1.60
  24. Brace C. Thermal tumor ablation in clinical use. IEEE Pulse 2011;2:28-38 https://doi.org/10.1109/MPUL.2011.942603