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CT Findings of Granulomatous Pneumocystis jiroveci Pneumonia in a Patient with Multiple Myeloma

다발성 골수종 환자에서 발생한 육아종성 폐포자충 폐렴의 컴퓨터단층촬영 소견

  • So Ra Shin (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Tae Sung Kim (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Joungho Han (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 신소라 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 김태성 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 한정호 (성균관대학교 의과대학 삼성서울병원 병리과)
  • Received : 2021.03.10
  • Accepted : 2021.04.17
  • Published : 2022.01.01

Abstract

Although the typical CT findings of Pneumocystis jiroveci pneumonia (PJP) include diffuse or multifocal areas of ground-glass opacities in both lungs, it can also rarely manifest as multiple pulmonary nodules. We report a rare case of atypical PJP in an immunocompromised patient with multiple myeloma, presenting as widespread ground-glass opacities and multiple necrotic subpleural nodules in both lungs on CT, which proved to be granulomatous PJP on percutaneous transthoracic needle biopsy.

폐포자충 폐렴의 전형적인 전산화단층촬영 소견은 양측 폐에 미만성 혹은 다발성의 간유리 음영으로 잘 알려져 있지만, 드물게 다발성 폐 결절 형태로 나타날 수도 있다. 본 저자들은 다발성 골수종 치료로 인해 면역력이 저하된 환자의 양측 폐에 생긴 광범위한 간유리음영 및 이와 동반된 다발성 괴사성 늑막하 결절들이 경피적 폐생검을 통해 육아종성 폐포자충 폐렴으로 확진된 증례를 보고한다.

Keywords

References

  1. Catherinot E, Lanternier F, Bougnoux ME, Lecuit M, Couderc LJ, Lortholary O. Pneumocystis jirovecii pneumonia. Infect Dis Clin North Am 2010;24:107-138
  2. Kanne JP, Yandow DR, Meyer CA. Pneumocystis jiroveci pneumonia: high-resolution CT findings in patients with and without HIV infection. AJR Am J Roentgenol 2012;198:W555-W561
  3. Fujii T, Nakamura T, Iwamoto A. Pneumocystis pneumonia in patients with HIV infection: clinical manifestations, laboratory findings, and radiological features. J Infect Chemother 2007;13:1-7
  4. Hardak E, Brook O, Yigla M. Radiological features of Pneumocystis jirovecii pneumonia in immunocompromised patients with and without AIDS. Lung 2010;188:159-163
  5. Travis WD, Pittaluga S, Lipschik GY, Ognibene FP, Suffredini AF, Masur H, et al. Atypical pathologic manifestations of Pneumocystis carinii pneumonia in the acquired immune deficiency syndrome. Review of 123 lung biopsies from 76 patients with emphasis on cysts, vascular invasion, vasculitis, and granulomas. Am J Surg Pathol 1990;14:615-625
  6. Lund FE, Hollifield M, Schuer K, Lines JL, Randall TD, Garvy BA. B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol 2006;176:6147-6154
  7. Hartel PH, Shilo K, Klassen-Fischer M, Neafie RC, Ozbudak IH, Galvin JR, et al. Granulomatous reaction to pneumocystis jirovecii: clinicopathologic review of 20 cases. Am J Surg Pathol 2010;34:730-734
  8. Lauffer L, Kini JA, Costello P, Godleski J. Granulomatous Pneumocystis carinii pneumonia in a non-AIDS patient: an atypical presentation. J Thorac Imaging 2004;19:196-199
  9. Ullmer E, Mayr M, Binet I, Ebnother-Staub C, Dalquen P, Soler M, et al. Granulomatous Pneumocystis carinii pneumonia in Wegener's granulomatosis. Eur Respir J 2000;15:213-216
  10. Kim HS, Shin KE, Lee JH. Single nodular opacity of granulomatous pneystis jirovecii pneumonia in an asymptomatic lymphoma patient. Korean J Radiol 2015;16:440-443