대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

교모세포종에 대한 통합암치료의 치료 효과 증례보고

A Case Report on the Therapeutic Effect of Integrated Cancer Therapy for Glioblastoma Multiforme

  • 양진성 (대전대학교 한의과대학 비계내과학 교실) ;
  • 장혁준 (대전대학교 한의과대학 비계내과학 교실) ;
  • 송시연 (대전대학교 한의과대학 비계내과학 교실) ;
  • 박지혜 (대전대학교 한의과대학 비계내과학 교실) ;
  • 박소정 (부산대학교 한방병원 한방내과) ;
  • 유화승 (대전대학교 한의과대학 비계내과학 교실)
  • Yang, Jin-sung (Dept. of Gastroenterology, School of Korean Medicine, Daejeon University) ;
  • Jang, Hyuk-jun (Dept. of Gastroenterology, School of Korean Medicine, Daejeon University) ;
  • Song, Si-yeon (Dept. of Gastroenterology, School of Korean Medicine, Daejeon University) ;
  • Park, Ji-hye (Dept. of Gastroenterology, School of Korean Medicine, Daejeon University) ;
  • Park, So-jung (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Yoo, Hwa-seung (Dept. of Gastroenterology, School of Korean Medicine, Daejeon University)
  • 투고 : 2022.03.17
  • 심사 : 2022.05.19
  • 발행 : 2022.05.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: The purpose of this report is to present the effects of integrative cancer treatment (ICT) on a patient diagnosed with glioblastoma multiforme (GBM). Methods: A 71-year-old male GBM patient received ICT from May 14 to October 12, 2021 and concurrently received temozolomide and radiotherapy. The effect on symptoms was evaluated using a visual analog scale (VAS), and changes in tumor size were assessed using magnetic resonance imaging. Results: After treatment, the VAS score for nausea decreased from 5 to 1, and the tumor size also reduced. Conclusion: ICT could be effective in treating GBM patients by reducing the size of the tumor as well as alleviating the side effects.

키워드

과제정보

본 연구는 보건복지부의 지원에 의하여 이루어진 것임(과제고유번호 : HI19C1046).

참고문헌

  1. Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, et al. Brain and other central nervous system tumor statistics, 2021. CA Cancer J Clin 2021;71(5):381-406. https://doi.org/10.3322/caac.21693
  2. Jung KW, Yoo H, Kong HJ, Won YJ, Park S, Lee SH. Population-based survival data for brain tumors in Korea. J Neurooncol 2012;109(2):301-7. https://doi.org/10.1007/s11060-012-0893-5
  3. Louis DN, Perry A, Reifenberger G, Deimling AV, Branger DF, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016;131(6):803-20. https://doi.org/10.1007/s00401-016-1545-1
  4. Verlut C, Mouillet G, Magnin E, Miny JB, Viennet G, Cattin F, et al. Age, Neurological Status MRC Scale, and Postoperative Morbidity are Prognostic Factors in Patients with Glioblastoma Treated by Chemoradiotherapy. Clin Med Insights Onco 2016;10:77-82.
  5. Nicholas S, Mathios D, Ruzevick J, Jackson C, Yang I, Lim M. Current Trends in Glioblastoma Multiforme Treatment: Radiation Therapy and Immune Checkpoint Inhibitors. Brain Tumor Res Treat 2013;1(1):2-8. https://doi.org/10.14791/btrt.2013.1.1.2
  6. Boo SJ. Self-care Agency and Quality of Life in Brain Tumor Patients after Surgery. Asian Oncol Nurs 2015;15(4):211-8. https://doi.org/10.5388/aon.2015.15.4.211
  7. Yang JN, Yun YJ, Hong JW, Han CW, Kwon JN, Lee I, et al. Case Report on Long Term Survival of Glioblastoma Patient Treated with Integrative Medicine. J Korean Med 2018;39(1):75-85. https://doi.org/10.13048/jkm.18008
  8. Lee HR, Oh JW, Kang MS, Lee EJ. A Case Report on Diarrhea after Chemotherapy in a Soeumin Patient with Glioblastoma. J Sasang Constitut Med 2019;31(4):65-73. https://doi.org/10.7730/JSCM.2019.31.4.65
  9. Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, et al. Selenium for preventing cancer. Cochrane Database Syst Rev 2018;1(1):CD005195.
  10. Tripathy J, Tripathy A, Thangaraju M, Suar M, Elangovan S. α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFb signaling. Life Sci 2018;207:15-22. https://doi.org/10.1016/j.lfs.2018.05.039
  11. Traverso N, Ricciarelli R, Nitti M, Marengo B, Furfaro AL, Pronzato MA, et al. Role of glutathione in cancer progression and chemoresistance. O id Med Cell Longev 2013;2013:972913.
  12. Bot ger F, Valles-Marti A, Cahn L, Jimenez CR. High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. J Exp Clin Cancer Res 2021;40(1):343. https://doi.org/10.1186/s13046-021-02134-y
  13. Lee JH, Lee JH, Lim YS, Yeon JE, Song TJ, Yu SJ, et al. Sustained efficacy of adjuvant immunotherapy with cytokine-induced killer cells for hepatocellular carcinoma: an extended 5-year follow-up. Cancer Immunol Immunother 2019;68(1):23-32. https://doi.org/10.1007/s00262-018-2247-4
  14. Seong JY, Joo JM. Inorganic Nanoparticles for Blood-Brain Barrier Penetration and Drug Delivery. Polymer Science and Technology 2021;32(3):216-23.
  15. Nam KY, Choi JE, Hong SC, Pyo MK, Park JD. Recent Progress in Research on Anticancer Activities of Ginsenoside-Rg3. Kor J Pharmacogn 2014;45(1):1-10.
  16. Peng Z, Wu WW, Yi P. The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol 2021;11:630825. https://doi.org/10.3389/fphar.2020.630825
  17. Pan L, Zhang T, Cao H, Sun H, Liu G. Ginsenoside Rg3 for Chemotherapy-Induced Myelosuppression: A Meta-Analysis and Systematic Review. Front Pharmacol 2020;11:649. https://doi.org/10.3389/fphar.2020.00649
  18. Yang P, Jiang Y, Pan Y, Ding X, Rhea P, Ding J, et al. Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression. Sci Rep 2019;9(1):6428. https://doi.org/10.1038/s41598-019-41444-2
  19. Jung HJ. Distribution of the studies on the sachonghyeol(Four Command Points) in Korea. Korean J Acupunct 2010;27(3);119-27.
  20. Pasqualini C, Kozaki T, Bruschi M, Nguyen THH, Minard-Colin VR, Castel D, et al. Modeling the Interaction between the Microenvironment and Tumor Cells in Brain Tumors. Neuron 2020;108(6):1025-44. https://doi.org/10.1016/j.neuron.2020.09.018
  21. Amani H, Habibey RH, Shokri FS, Hajmiresmail SJ, Akhavan O, Mashaghi AZ, et al. Selenium nanoparticles for targeted stroke therapy through modulation of infammatory and metabolic signaling. Sci Rep 2019;9(1):6044. https://doi.org/10.1038/s41598-019-42633-9