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RNA Metabolism in T Lymphocytes

  • Jin Ouk Choi (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Severance Biomedical Science Institute and Brain Korea 21 Project, Yonsei University College of Medicine) ;
  • Jeong Hyeon Ham (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Severance Biomedical Science Institute and Brain Korea 21 Project, Yonsei University College of Medicine) ;
  • Soo Seok Hwang (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Severance Biomedical Science Institute and Brain Korea 21 Project, Yonsei University College of Medicine)
  • Received : 2022.04.06
  • Accepted : 2022.08.30
  • Published : 2022.10.31
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Abstract

RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during T cell phase transition. Thymic selection, quiescence maintenance, activation, differentiation, and effector functions of T cells are dependent on selective RNA modulations. Recent technical improvements have unveiled the complex crosstalk between RNAs and T cells. Moreover, resting T cells contain large amounts of untranslated mRNAs, implying that the regulation of RNA metabolism might be a key step in controlling gene expression. Considering the immunological significance of T cells for disease treatment, an understanding of RNA metabolism in T cells could provide new directions in harnessing T cells for therapeutic implications.

Keywords

Acknowledgement

We thank all members of the Department of Biochemistry and Molecular Biology of Yonsei University College of Medicine for administrative support. This work was supported by the Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine. This work of SSH was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1A2C2093640 and 2018R1A5A2025079) and a faculty research grant (6-2021-0156) and a new faculty research seed money grant (2021-32-0055) of Yonsei University College of Medicine.

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