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  • 제22권4호
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  • Pages.32.1-32.20
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  • 2022
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Why Should We Consider Potential Roles of Oral Bacteria in the Pathogenesis of Sjögren Syndrome?

  • Sung-Ho Chang (Department of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute, Seoul National University) ;
  • Sung-Hwan Park (Divison of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Mi-La Cho (Department of Medical Life Science, College of Medicine, The Catholic University of Korea) ;
  • Youngnim Choi (Department of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute, Seoul National University)
  • 투고 : 2022.04.23
  • 심사 : 2022.06.22
  • 발행 : 2022.08.31
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초록

Sjögren syndrome (SS) is a chronic autoimmune disorder that primarily targets the salivary and lacrimal glands. The pathology of these exocrine glands is characterized by periductal focal lymphocytic infiltrates, and both T cell-mediated tissue injury and autoantibodies that interfere with the secretion process underlie glandular hypofunction. In addition to these adaptive mechanisms, multiple innate immune pathways are dysregulated, particularly in the salivary gland epithelium. Our understanding of the pathogenetic mechanisms of SS has substantially improved during the past decade. In contrast to viral infection, bacterial infection has never been considered in the pathogenesis of SS. In this review, oral dysbiosis associated with SS and evidence for bacterial infection of the salivary glands in SS were reviewed. In addition, the potential contributions of bacterial infection to innate activation of ductal epithelial cells, plasmacytoid dendritic cells, and B cells and to the breach of tolerance via bystander activation of autoreactive T cells and molecular mimicry were discussed. The added roles of bacteria may extend our understanding of the pathogenetic mechanisms and therapeutic approaches for this autoimmune exocrinopathy.

키워드

과제정보

This study was supported by the National Research Foundation of Korea (Daejun, Korea) through the grants 2018R1A5A2024418 and 2020R1A2C2007038 awarded to Youngnim Choi and a grant 2020R1A2C1100163 awarded to Sung-Ho Chang.

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