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  • 제22권2호
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  • Pages.16.1-16.20
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  • 2022
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Change of Dendritic Cell Subsets Involved in Protection Against Listeria monocytogenes Infection in Short-Term-Fasted Mice

  • Young-Jun Ju (Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University) ;
  • Kyung-Min Lee (Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University) ;
  • Girak Kim (Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University) ;
  • Yoon-Chul Kye (Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University) ;
  • Han Wool Kim (Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University) ;
  • Hyuk Chu (Division of Zoonotic and Vector Borne Disease Research, Center for Infectious Disease Research, National Institute of Health) ;
  • Byung-Chul Park (Institute of Green Bio Science and Technology, Seoul National University) ;
  • Jae-Ho Cho (Department of Microbiology and Immunology, Chonnam National University Medical School, Hwasun Hospital) ;
  • Pahn-Shick Chang (Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University) ;
  • Seung Hyun Han (Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Cheol-Heui Yun (Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University)
  • 투고 : 2021.09.03
  • 심사 : 2022.03.13
  • 발행 : 2022.04.30
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초록

The gastrointestinal tract is the first organ directly affected by fasting. However, little is known about how fasting influences the intestinal immune system. Intestinal dendritic cells (DCs) capture antigens, migrate to secondary lymphoid organs, and provoke adaptive immune responses. We evaluated the changes of intestinal DCs in mice with short-term fasting and their effects on protective immunity against Listeria monocytogenes (LM). Fasting induced an increased number of CD103+CD11b- DCs in both small intestinal lamina propria (SILP) and mesenteric lymph nodes (mLN). The SILP CD103+CD11b- DCs showed proliferation and migration, coincident with increased levels of GM-CSF and C-C chemokine receptor type 7, respectively. At 24 h post-infection with LM, there was a significant reduction in the bacterial burden in the spleen, liver, and mLN of the short-term-fasted mice compared to those fed ad libitum. Also, short-term-fasted mice showed increased survival after LM infection compared with ad libitum-fed mice. It could be that significantly high TGF-β2 and Aldh1a2 expression in CD103+CD11b- DCs in mice infected with LM might affect to increase of Foxp3+ regulatory T cells. Changes of major subset of DCs from CD103+ to CD103- may induce the increase of IFN-γ-producing cells with forming Th1-biased environment. Therefore, the short-term fasting affects protection against LM infection by changing major subset of intestinal DCs from tolerogenic to Th1 immunogenic.

키워드

과제정보

This work was carried out with the support of Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ016201 and Project No. PJ016613), Rural Development Administration, Republic of Korea. Y-JJ, K-ML, GK, Y-CK, and HWK were supported by the BK21 Plus Program of the Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.

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