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The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease

  • Chan-Su Park (Department of Pathology, Johns Hopkins University School of Medicine) ;
  • Nilabh Shastri (Department of Pathology, Johns Hopkins University School of Medicine)
  • Received : 2021.11.30
  • Accepted : 2022.01.10
  • Published : 2022.02.28
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Abstract

Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of adipose tissue and the intestines from anti-inflammatory to pro-inflammatory, which promotes low grade systemic inflammation and insulin resistance in obese mice. Various T cell subsets either help maintain metabolic homeostasis in healthy states or contribute to obesity-associated metabolic syndromes. In this review, we will discuss the T cell subsets that reside in adipose tissue and intestines and their role in the development of obesity-induced systemic inflammation.

Keywords

Acknowledgement

We thank Scheherazade Sadegh-Nasseri for suggestions and guidance on the manuscript and J David Peske and Jesus Contreras Rodriguez for editorial comments. This work was supported by NIH grant (R01AI130210, R01AI121174, R37AI060040).

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