Journal of Chest Surgery

  • 제55권3호
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  • Pages.214-224
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  • 2022
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  • 2765-1606(pISSN)
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  • 2765-1614(eISSN)
대한심장혈관흉부외과학회 (The Korean Society for Thoracic and Cardiovascular Surgery)
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Prognostic Role of Circulating Tumor Cells in the Pulmonary Vein, Peripheral Blood, and Bone Marrow in Resectable Non-Small Cell Lung Cancer

  • Lee, Jeong Moon (Department of Thoracic and Cardiovascular Surgery, Wonkwang University School of Medicine) ;
  • Jung, Woohyun (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital) ;
  • Yum, Sungwon (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital) ;
  • Lee, Jeong Hoon (Division of Biomedical Informatics, Seoul National University Biomedical Informatics, Seoul National University College of Medicine) ;
  • Cho, Sukki (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital)
  • 투고 : 2021.11.17
  • 심사 : 2022.03.02
  • 발행 : 2022.06.05
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초록

Background: Studies of the prognostic role of circulating tumor cells (CTCs) in early-stage non-small cell lung cancer (NSCLC) are still limited. This study investigated the prognostic power of CTCs from the pulmonary vein (PV), peripheral blood (PB), and bone marrow (BM) for postoperative recurrence in patients who underwent curative resection for NSCLC. Methods: Forty patients who underwent curative resection for NSCLC were enrolled. Before resection, 10-mL samples were obtained of PB from the radial artery, blood from the PV of the lobe containing the tumor, and BM aspirates from the rib. A microfabricated filter was used for CTC enrichment, and immunofluorescence staining was used to identify CTCs. Results: The pathologic stage was stage I in 8 patients (20%), II in 15 (38%), III in 14 (35%), and IV in 3 (8%). The median number of PB-, PV-, and BM-CTCs was 4, 4, and 5, respectively. A time-dependent receiver operating characteristic curve analysis showed that PB-CTCs had excellent predictive value for recurrence-free survival (RFS), with the highest area under the curve at each time point (first, second, and third quartiles of RFS). In a multivariate Cox proportional hazard regression model, PB-CTCs were an independent risk factor for recurrence (hazard ratio, 10.580; 95% confidence interval, 1.637-68.388; p<0.013). Conclusion: The presence of ≥4 PB-CTCs was an independent poor prognostic factor for RFS, and PV-CTCs and PB-CTCs had a positive linear correlation in patients with recurrence.

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과제정보

This work was supported by the SNUBH Research Fund (grant no., 02-2014-068).

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