DOI QR코드

DOI QR Code

A Review of the Clinical Study Trends on Korean Medicine Treatment for Polycystic Ovary Syndrome

다낭성 난소 증후군의 한의학적 치료에 대한 국내 임상 연구 고찰

  • Cho, Yu-Jin (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Lee, Yoon-Jae (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Ahn, Young-Tae (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Kang, Eun-Sol (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Kim, Hyo-Jeong (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Hong, Doo-Hyun (Dept. of Korean Neuropsychiatry, Jaseng Hospital of Korean Medicine) ;
  • Park, Kyoung-Sun (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine)
  • 조유진 (자생한방병원 한방부인과) ;
  • 이윤재 (자생의료재단 척추관절연구소) ;
  • 안영태 (자생한방병원 한방부인과) ;
  • 강은솔 (자생한방병원 한방부인과) ;
  • 김효정 (자생한방병원 한방부인과) ;
  • 홍두현 (자생한방병원 한방신경정신과) ;
  • 박경선 (자생한방병원 한방부인과)
  • Received : 2022.04.22
  • Accepted : 2022.05.27
  • Published : 2022.05.27

Abstract

Objectives: The purpose of this study is to analysis the Clinical Study Trends on Korean Medicine Treatment for Polycystic Ovary Syndrome. Methods: The key words such as 'polycystic ovary syndrome', 'polycystic ovarian syndrome', 'korean medicine', 'herbal medicine', 'acupuncture' are used for the research through 'OASIS', 'KCI', 'KISS', 'RISS'. Results: Ten clinical studies with 73 patients were selected. All studies were the noncomparative studies, and 8 case reports, 1 case series, 1 retrospective chart review. Symptoms accompanied by PCOS were oligomenorrhea, amenorrhea, irregular menstruation, hirsutism, acne, obesity etc. The most used treatment was herbal medicine in all studies with 72 patients (98.6%). The most frequently used acupuncture and moxibustion point was respectively 合谷 (LI4) and 關元 (CV4). The duration of treatment was between 3 months and 10 months, the average 159 days. Outcome measurements were Recovery of menstrual cycle (97.6%), Hormone test (23.8%), Sonogram (61.9%), Indexes of obesity (23.8%). In terms of menstrual recovery, 35 patients (85.4%) have recovered from menstruation in 8 studies with 41 patients. In hormone tests, all 10 patients have decrease of LH/FSH ratio and LH in 3 studies with 10 patients. Through sonogram, Ovulation menstruation was confirmed in all 6 patients. In all 10 patients of 3 studies evaluating weight before and after treatment, weight was reduced. Conclusions: The effect on Korean Medicine treatment for Polycystic Ovary Syndrome had mostly positive results. However, Further large, well-designed clinical trials are needed to establish the foundation of Korean Medicine treatment for Polycystic Ovary Syndrome.

Keywords

References

  1. Hart R, Hickey M, Franks S. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Practice & Research Clinical Obstetrics & Gynaecology. 2004;8(5):671-83. https://doi.org/10.1016/j.bpobgyn.2004.05.001
  2. Health Insurance Review & Assessment Service [Internet]. [cite 2022 April 7]. Available from:http://opendata.hira.or.kr/op/opc/olap4thDsInfo.do
  3. Azziz R. Polycystic ovary syndrome. Obstetrics & Gynecology. 2018;132(2):321-36. https://doi.org/10.1097/AOG.0000000000002698
  4. The Society of Korean Medicine Obstetrics and Gynecology. Oriental Obstetrics & Gynecology (2nd volume). 3rd rev. ed. Seoul:Euiseongdang. 2016:182-92.
  5. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nature Reviews Endocrinology. 2018;14(5):270-84. https://doi.org/10.1038/nrendo.2018.24
  6. Yoon JG, et al. Electroacupuncture for Treatment of Polycystic Ovarian Syndrome: Systematic Review of Randomized Controlled Trials. The Journal of Korean Obstetrics and Gynecology. 2018;31(4):39-53. https://doi.org/10.15204/JKOBGY.2018.31.4.039
  7. Park EJ, et al. A correlation study of pattern identification instrument and biomarkers for polycystic ovary syndrome. The Journal of Korean Obstetrics and Gynecology. 2018;31(3):33-49. https://doi.org/10.15204/JKOBGY.2018.31.3.033
  8. Park EJ, et al. Preliminary Study on Development of Pattern Identification Instrument for Polycystic Ovarian Syndrome. The Journal of Korean Obstetrics and Gynecology. 2017;30(1):68-84. https://doi.org/10.15204/JKOBGY.2017.30.1.068
  9. Yeo EJ, et al. Effects of Pinelliae Rhizoma (PR) on Ovarian Tissue in Polycystic Ovary Syndrome (PCOS) Rats. The Journal of Korean Obstetrics and Gynecology. 2012;25(2):66-77. https://doi.org/10.15204/JKOBGY.2012.25.2.066
  10. Yang DS, et al. Effects of Cyperi Rhizoma (CR) on the polycystic ovaries induced by estradiol valerate in rats. The Journal of Korean Obstetrics and Gynecology. 2010;23(4):35-46. https://doi.org/10.15204/JKOBGY.2010.23.4.035
  11. Yang JM, et al. Effects of J okyeongjongok-Tang on the Maturation of Follicles and NGF Expression in Rats with Estradiol Valerate-induced Polycystic Ovaries. The Journal of Korean Obstetrics and Gynecology. 2011;24(2):52-67. https://doi.org/10.15204/JKOBGY.2011.24.2.052
  12. Park SY, Park KD, Yoon YJ. A Study on the Clinical Study of Herbal Medicine for Glucose-Lipid Metabolism Abnormalities in Polycystic Ovary Syndrome. The Journal of Korean Obstetrics and Gynecology. 2019;32(4):67-86. https://doi.org/10.15204/JKOBGY.2019.32.4.067
  13. Won AN, Choi MS, Kim DI. A Review on Clinical Studies of Herbal Treatment for Infertility Caused by Polycystic Ovary Syndrome-Focusing on Chinese Clinical Trials. The Journal of Korean Obstetrics and Gynecology. 2014;27(4):43-56. https://doi.org/10.15204/JKOBGY.2014.27.4.043
  14. Kim SH, et al. Recent acupuncture therapy for polycystic ovary syndromes: systematic review. The Journal of Korean Obstetrics and Gynecology. 2014;27(2):71-82. https://doi.org/10.15204/JKOBGY.2014.27.2.071
  15. Shin HG, et al. A Case Series of Polycystic Ovary Syndrome with Improved Hyperandrogenism Treated with Korean Medicine. The Journal of Korean Obstetrics and Gynecology. 2021;34(3):175-91. https://doi.org/10.15204/JKOBGY.2021.34.3.175
  16. Kim MW, et al. Case Report of Patients of Oligomenorrhea due to Polycystic Ovarian Syndrome Improved by Jokyeongjongok-tang-gami. The Journal of Korean Obstetrics and Gynecology. 2020;33(3):175-86. https://doi.org/10.15204/JKOBGY.2020.33.3.175
  17. Hwangbo SM, et al. 6 Cases of Polycystic Ovarian Disease Patients Recovering Ovulatory Menstrual Cycle with the Korean Medical Treatment: a Case Report. The Journal of Korean Obstetrics and Gynecology. 2019;32(1):108-26. https://doi.org/10.15204/JKOBGY.2019.32.1.108
  18. Jung MY, Yoo JE. A case report of polycystic ovary syndrome treated by Sajaehyangbu-hwan. The Journal of Korean Medicine. 2018;39(3):101-9. https://doi.org/10.13048/jkm.18029
  19. Lee JH, Jung SY. Case report of 20 amenorrhea or oligomenorrhea patients due to polycystic ovarian syndrome. The Journal of Korean Obstetrics and Gynecology. 2016;29(3):47-56. https://doi.org/10.15204/JKOBGY.2016.29.3.047
  20. Kim JY, Jung SY. Clinical study for the one case that diagnosed polycystic ovarian disease. The Journal of Korean Obstetrics and Gynecology. 2014;27(3):151-7. https://doi.org/10.15204/JKOBGY.2014.27.3.151
  21. Oh TG, et al. Clinical Study for the One Case that Diagnosed Polycystic Ovarian Disease. The Journal of Korean Obstetrics and Gynecology. 2008;21(2):284-91.
  22. Kim DH. A case study on obese patient with oligomenorrhea and polycystic ovary. Journal of Korean Medicine for Obesity Research. 2008;8(1):101-8.
  23. Lee JS. A case study on inferility with obesity and polycystic ovary. Journal of Korean Medicine for Obesity Research. 2005;5(1):157-63.
  24. Park SH, et al. Analysis of the characteristics and treatment of polycystic ovary syndrome patients in a Korean medicine hospital. The Journal of Korean Obstetrics and Gynecology. 2019;32(1):37-47. https://doi.org/10.15204/JKOBGY.2019.32.1.037
  25. Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clinical epidemiology. 2014;6:1. https://doi.org/10.2147/CLEP.S37559
  26. Min EG. The polycystic ovary syndrome. Korean Journal of Obstetrics and Gynecology. 2008;51(8):805-19.
  27. Vandenbroucke JP, et al. Oral contraceptives and the risk of venous thrombosis. New England Journal of Medicine. 2001;344(20):1527-35. https://doi.org/10.1056/NEJM200105173442007
  28. Yang SJ, et al. Effects of Changbu DodamTang on the Polycystic Ovaries Induced by Estradiol Valerate in Rats. The Journal of Korean Obstetrics and Gynecology. 2002;15(2):1-1.
  29. Ahn KH, et al. Effects of Guisinhwan on the ovulation and ovary in rats. The Journal of Korean Obstetrics and Gynecology. 2005;18(3):1-16.
  30. Kwon CY, Cho IH, Park KS. Therapeutic effects and mechanisms of herbal medicines for treating polycystic ovary syndrome: a review. Frontiers in Pharmacology. 2020;11:1192. https://doi.org/10.3389/fphar.2020.01192
  31. Stener-Victorin E, et al. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Acta obstetricia et gynecologica Scandinavica. 2000;79(3):180-8. https://doi.org/10.1080/j.1600-0412.2000.079003180.x
  32. Kwon SR, et al. Effects of electroacupuncture on Samumgyo (SP-6) Chagung (CA-111) on polycystic ovary in rats. Korean Journal of Obstetrics and Gynecology. 2003;16(2):76-86.
  33. Ko JH, Kim KJ. Comparison of body composition according to the obesity types based upon percent body fat, BMI and waist circumference in women. J Growth and Development. 2007;15(1):1-7.