과제정보
This study was supported by the KU Research Professor Program of Konkuk University.
참고문헌
- Nyakudya E, Jeong JH, Lee NK, Jeong YS. 2014. Platycosides from the roots of Platycodon grandiflorum and their health benefits. Prev. Nutr. Food Sci. 19: 59-68. https://doi.org/10.3746/PNF.2014.19.2.059
- Kim JY, Hwang YP, Kim DH, Han EH, Chung YC, Roh SH, et al. 2006. Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation. Biosci. Biotechnol. Biochem. 70: 858-864. https://doi.org/10.1271/bbb.70.858
- Kim M, Hwang IG, Kim SB, Choi AJ. 2020. Chemical characterization of balloon flower (Platycodon grandiflorum) sprout extracts and their regulation of inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Food Sci. Nutr. 8: 246-256. https://doi.org/10.1002/fsn3.1297
- Ryu CS, Kim CH, Lee SY, Lee KS, Choung KJ, Song GY, et al. 2012. Evaluation of the total oxidant scavenging capacity of saponins isolated from Platycodon grandiflorum. Food Chem. 132: 333-337. https://doi.org/10.1016/j.foodchem.2011.10.086
- Luo H, Lin S, Ren F, Wu L, Chen L, Sun Y. 2007. Antioxidant and antimicrobial capacity of Chinese medicinal herb extracts in raw sheep meat. J. Food Prot. 70: 1440-1445. https://doi.org/10.4315/0362-028X-70.6.1440
- Xie Y, Ye YP, Sun HX, Li D. 2008. Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenin-type saponins from the root of Platycodon grandiflorum. Vaccine 26: 3452-3460. https://doi.org/10.1016/j.vaccine.2008.04.023
- Noh EM, Kim JM, Lee HY, Song HK, Joung SO, Yang HJ, et al. 2019. Immuno-enhancement effects of Platycodon grandiflorum extracts in splenocytes and a cyclophosphamide-induced immunosuppressed rat model. BMC Complement. Altern. Med. 19: 322. https://doi.org/10.1186/s12906-019-2724-0
- Zhao X, Wang Y, Yan P, Cheng G, Wang C, Geng N, et al. 2017. Effects of polysaccharides from Platycodon grandiflorum on immunity-enhancing activity in vitro. Molecules 22: 1918. https://doi.org/10.3390/molecules22111918
- Yim NH, Hwang YH, Liang C, Ma JY. 2016. A platycoside-rich fraction from the root of Platycodon grandiflorum enhances cell death in A549 human lung carcinoma cells via mainly AMPK/mTOR/AKT signal-mediated autophagy induction. J. Ethnopharmacol. 194: 1060-1068. https://doi.org/10.1016/j.jep.2016.10.078
- Kim YS, Kim JS, Choi SU, Kim JS, Lee HS, Roh SH, et al. 2005. Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines. Planta Med. 71: 566-568. https://doi.org/10.1055/s-2005-864161
- Khan M, Maryam A, Zhang H, Mehmood T, Ma T. 2016. Killing cancer with platycodin D through multiple mechanisms. J. Cell Mol. Med. 20: 389-402. https://doi.org/10.1111/jcmm.12749
- Han LK, Zheng YN, Xu BJ, Okuda H, Kimura Y. 2002. Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. J. Nutr. 132: 2241-2245. https://doi.org/10.1093/jn/132.8.2241
- Zhao HL, Harding SV, Marinangeli CP, Kim YS, Jones PJ. 2008. Hypocholesterolemic and anti-obesity effects of saponins from Platycodon grandiflorum in hamsters fed atherogenic diets. J. Food Sci. 73: H195-200. https://doi.org/10.1111/j.1750-3841.2008.00915.x
- Hwang KA, Hwang YJ, Im PR, Hwang HJ, Song J, Kim YJ. 2019. Platycodon grandiflorum extract reduces high-fat diet-induced obesity through regulation of adipogenesis and lipogenesis pathways in mice. J. Med. Food 22: 993-999. https://doi.org/10.1089/jmf.2018.4370
- Ha YW, Na YC, Seo JJ, Kim SN, Linhardt RJ, Kim YS. 2006. Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry. J. Chromatogr. A. 1135: 27-35. https://doi.org/10.1016/j.chroma.2006.09.015
- Yoo DS, Choi YH, Cha MR, Lee BH, Kim SJ, Yon GH, et al. 2011. HPLC-ELSD analysis of 18 platycosides from balloon flower roots (Platycodi Radix) sourced from various regions in Korea and geographical clustering of the cultivation areas. Food Chem. 129: 645-651. https://doi.org/10.1016/j.foodchem.2011.04.106
- Park CS, Yoo MH, Noh KH, Oh DK. 2010. Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Appl. Microbiol. Biotechnol. 87: 9-19. https://doi.org/10.1007/s00253-010-2567-6
- Shin KC, Oh DK. 2016. Classification of glycosidases that hydrolyze the specific positions and types of sugar moieties in ginsenosides. Crit. Rev. Biotechnol. 36: 1036-1049. https://doi.org/10.3109/07388551.2015.1083942
- Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK, et al. 2000. Steaming of ginseng at high temperature enhances biological activity. J. Nat. Prod. 63: 1702-1704. https://doi.org/10.1021/np990152b
- Zhou W, Yan Q, Li JY, Zhang XC, Zhou P. 2008. Biotransformation of Panax notoginseng saponins into ginsenoside compound K production by Paecilomyces bainier sp. 229. J. Appl. Microbiol. 104: 699-706. https://doi.org/10.1111/j.1365-2672.2007.03586.x
- Jiang Y, Li W, Fan D. 2021. Biotransformation of ginsenoside Rb1 to ginsenoside CK by strain XD101: a safe bioconversion strategy. Appl. Biochem. Biotechnol. 193: 2110-2127. https://doi.org/10.1007/s12010-021-03485-0
- Shin KC, Kim DW, Oh YJ, Seo MJ, Na CS, Kim YS. 2021. Improved production of deglucosylated platycodin D from saponins from balloon flower leaf by a food-grade enzyme using high hydrostatic pressure. Heliyon 7: e08104. https://doi.org/10.1016/j.heliyon.2021.e08104
- Ahn HJ, You HJ, Park MS, Johnston TV, Ku S, Ji GE. 2018. Biocatalysis of platycoside E and platycodin D3 using fungal extracellular β-glucosidase responsible for rapid platycodin D production. Int. J. Mol. Sci. 19: 2671. https://doi.org/10.3390/ijms19092671
- Shin KC, Seo MJ, Kim DW, Yeom SJ, Kim YS. 2019. Characterization of β-glycosidase from Caldicellulosiruptor owensensis and its application in the production of platycodin D from balloon flower leaf. Catalysts 9: 1025. https://doi.org/10.3390/catal9121025
- Kil TG, Kang SH, Kim TH, Shin KC, Oh DK. 2019. Enzymatic biotransformation of balloon flower root saponins into bioactive platycodin D by deglucosylation with Caldicellulosiruptor bescii β-glucosidase. Int. J. Mol. Sci. 20: 3854. https://doi.org/10.3390/ijms20163854
- Kang SH, Kim TH, Shin KC, Ko YJ, Oh DK. 2019. Biotransformation of food-derived saponins, platycosides, into deglucosylated saponins Including deglucosylated platycodin D and their anti-inflammatory activities. J. Agric. Food Chem. 67: 1470-1477. https://doi.org/10.1021/acs.jafc.8b06399
- Jeong EK, Ha IJ, Kim YS, Na YC. 2014. Glycosylated platycosides: identification by enzymatic hydrolysis and structural determination by LC-MS/MS. J. Sep. Sci. 37: 61-68. https://doi.org/10.1002/jssc.201300918
- Li W, Zhao LC, Wang Z, Zheng YN, Liang J, Wang H. 2012. Response surface methodology to optimize enzymatic preparation of deapio-platycodin D and platycodin D from radix platycodi. Int. J. Mol. Sci. 13: 4089-4100. https://doi.org/10.3390/ijms13044089
- Ha IJ, Ha YW, Kang M, Lee J, Park D, Kim YS. 2010. Enzymatic transformation of platycosides and one-step separation of platycodin D by high-speed countercurrent chromatography. J. Sep. Sci. 33: 1916-1922. https://doi.org/10.1002/jssc.200900842
- Wie HJ, Zhao HL, Chang JH, Kim YS, Hwang IK, Ji GE. 2007. Enzymatic modification of saponins from Platycodon grandiflorum with Aspergillus niger. J. Agric. Food Chem. 55: 8908-8913. https://doi.org/10.1021/jf0716937
- Shin KC, Kil TG, Lee TE, Oh DK. 2021. Production of bioactive beapiosylated platycosides from glycosylated platycosides in balloon flower root using the crude enzyme from the food-available fungus Rhizopus oryzae. J. Agric. Food Chem. 69: 4766-4777. https://doi.org/10.1021/acs.jafc.0c06756
- Shin KC, Kim DW, Woo HS, Oh DK, Kim YS. 2020. Conversion of glycosylated platycoside E to deapiose-xylosylated platycodin D by cytolase PCL5. Int. J. Mol. Sci. 21: 1207. https://doi.org/10.3390/ijms21041207
- Kim SA, Jeong EB, Oh DK. 2021. Complete bioconversion of protopanaxadiol-type ginsenosides to compound k by extracellular enzymes from the isolated strain Aspergillus tubingensis. J. Agric. Food Chem. 69: 315-324. https://doi.org/10.1021/acs.jafc.0c07424
- Jeong EB, Kim SA, Shin KC, Oh DK. 2020. Biotransformation of protopanaxadiol-type ginsenosides in Korean ginseng extract into food-available compound K by an extracellular enzyme from Aspergillus niger. J. Microbiol. Biotechnol. 30: 1560-1567. https://doi.org/10.4014/jmb.2007.07003
- Lara-Espinoza C, Carvajal-Millan E, Balandran-Quintana R, Lopez-Franco Y, Rascon-Chu A. 2018. Pectin and pectin-based composite materials: beyond food texture. Molecules 23: 942. https://doi.org/10.3390/molecules23040942