과제정보
This research was supported by the Korean Society of Ginseng (2020).
참고문헌
- Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 2008;83(5):584-94. https://doi.org/10.4065/83.5.584
- Tang C, Qin S, Wu W, Wu Y, Zhang T. Efficacy and potential application of neoadjuvant chemotherapy in patients with IIIa stage non-small cell lung cancer. Zhongguo Fei Ai Za Zhi 2017;20(2):100-6.
- Rossi A, La Salvia A, Di Maio M. Chemotherapy and intercalated gefitinib or erlotinib in the treatment of advanced non-small-cell lung cancer. Expert Rev Respir Med 2017;11(3):171-80. https://doi.org/10.1080/17476348.2017.1290526
- Tas F, Yildiz I, Kilic L, Ciftci R, Keskin S, Sen F. Same chemotherapy regimen leads different myelotoxicity in different malignancies: a comparison of chemotherapy-associated myelotoxicity in patients with advanced ovarian and non-small-cell lung cancer. Am J Ther 2016;23(3):e670-9. https://doi.org/10.1097/MJT.0b013e31828232b8
- Bock FJ, Tait SWG. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol 2020;21(2):85-100. https://doi.org/10.1038/s41580-019-0173-8
- Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281(5381):1309-12. https://doi.org/10.1126/science.281.5381.1309
- Chen Z, Berquez M, Luciani A. Mitochondria, mitophagy, and metabolic disease: towards assembling the puzzle. Cell Stress 2020;4(6):147-50. https://doi.org/10.15698/cst2020.06.222
- Zhang J. Autophagy and mitophagy in cellular damage control. Redox Biol 2013;1(1):19-23. https://doi.org/10.1016/j.redox.2012.11.008
- Kulikov AV, Luchkina EA, Gogvadze V, Zhivotovsky B. Mitophagy: link to cancer development and therapy. Biochem Biophys Res Commun 2017;482(3):432-9. https://doi.org/10.1016/j.bbrc.2016.10.088
- Fulda S, Galluzzi L, Kroemer G. Targeting mitochondria for cancer therapy. Nat Rev Drug Discov 2010;9(6):447-64. https://doi.org/10.1038/nrd3137
- Smith AG, Macleod KF. Autophagy, cancer stem cells and drug resistance. J Pathol 2019;247(5):708-18. https://doi.org/10.1002/path.5222
- Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2013;20(1):31-42. https://doi.org/10.1038/cdd.2012.81
- Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010;8(1):e1000298. https://doi.org/10.1371/journal.pbio.1000298
- Xiao B, Goh JY, Xiao L, Xian H, Lim KL, Liou YC. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem 2017;292(40):16697-708. https://doi.org/10.1074/jbc.M117.787739
- Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 2010;189(2):211-21. https://doi.org/10.1083/jcb.200910140
- Lee JW, Mo EJ, Choi JE, Jo YH, Jang H, Jeong JY, et al. Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology. J Ginseng Res 2016;40(3):229-36. https://doi.org/10.1016/j.jgr.2015.08.001
- Wang CZ, Anderson S, Du W, He TC, Yuan CS. Red ginseng and cancer treatment. Chin J Nat Med 2016;14(1):7-16. https://doi.org/10.3724/SP.J.1009.2016.00007
- Mohanan P, Subramaniyam S, Mathiyalagan R, Yang DC. Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions. J Ginseng Res 2018;42(2):123-32. https://doi.org/10.1016/j.jgr.2017.01.008
- Herceg Z, Wang ZQ. Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Mol Cell Biol 1999;19(7):5124-33. https://doi.org/10.1128/mcb.19.7.5124
- Eiyama A, Okamoto K. PINK1/Parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol 2015;33:95-101. https://doi.org/10.1016/j.ceb.2015.01.002
- Yang Y, Karakhanova S, Hartwig W, D'Haese JG, Philippov PP, Werner J, et al. Mitochondria and mitochondrial ROS in cancer: novel targets for anticancer therapy. J Cell Physiol 2016;231(12):2570-81. https://doi.org/10.1002/jcp.25349
- Chen T, Li B, Qiu Y, Qiu Z, Qu P. Functional mechanism of Ginsenosides on tumor growth and metastasis. Saudi J Biol Sci 2018;25(5):917-22. https://doi.org/10.1016/j.sjbs.2018.01.012
- Wang CH, Wu SB, Wu YT, Wei YH. Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging. Exp Biol Med (Maywood) 2013;238(5):450-60. https://doi.org/10.1177/1535370213493069
- Sinha K, Das J, Pal PB, Sil PC. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 2013;87(7):1157-80. https://doi.org/10.1007/s00204-013-1034-4
- Moungjaroen J, Nimmannit U, Callery PS, Wang L, Azad N, Lipipun V, et al. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J Pharmacol Exp Ther 2006;319(3):1062-9. https://doi.org/10.1124/jpet.106.110965
- Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 2011;36(1):30-8. https://doi.org/10.1016/j.tibs.2010.07.007
- Yoo SM, Jung YK. A molecular approach to mitophagy and mitochondrial dynamics. Mol Cells 2018;41(1):18-26. https://doi.org/10.14348/MOLCELLS.2018.2277
- Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008;183(5):795-803. https://doi.org/10.1083/jcb.200809125
- Tilija Pun N, Jang WJ, Jeong CH. Role of autophagy in regulation of cancer cell death/apoptosis during anti-cancer therapy: focus on autophagy flux blockade. Arch Pharm Res 2020;43(5):475-88. https://doi.org/10.1007/s12272-020-01239-w
- Bialik S, Dasari SK, Kimchi A. Autophagy-dependent cell death - where, how and why a cell eats itself to death. J Cell Sci 2018;131(18).