Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
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Development and Clinical Application of Real-Time Light-Guided Vocal Fold Injection

실시간 광유도 성대주입술의 개발과 임상적 적용

  • Huh, Gene (Department of Otorhinolaryngology-Head & Neck Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Cha, Wonjae (Department of Otorhinolaryngology-Head & Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • 허진 (가톨릭대학교 의과대학 성빈센트병원 이비인후-두경부외과학교실) ;
  • 차원재 (서울대학교 의과대학 분당서울대학교병원 이비인후-두경부외과학교실)
  • Received : 2021.12.06
  • Accepted : 2021.12.27
  • Published : 2022.04.30
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Abstract

Vocal fold injection (VFI) is widely accepted as a first line treatment in treating unilateral vocal fold paralysis and other vocal fold diseases. Although VFI is advantageous for its minimal invasiveness and efficiency, the invisibility of the needle tip remains an essential handicap in precise localization. Real-time light-guided vocal fold injection (RL-VFI) is a novel technique that was developed under the concept of performing simultaneous injection with precise placement of the needle tip under light guidance. RL-VFI has confirmed its possibility of technical implementation and the feasibility in injecting the needle from various directions through ex vivo animal studies. Further in vivo animal study has approved the safety and feasibility of the procedure when various transcutaneous approaches were applied. Currently, RL-VFI device is authorized for clinical use by the Ministry of Food and Drug Safety in South Korea and is clinically applied to patients with safe and favorable outcome. Several clinical studies are currently under process to approve the safety and the efficiency of RL-VFI. RL-VFI is expected to improve the complication rate and the functional outcome of voice. Furthermore, it will support laryngologists in overcoming the steep learning curve by its intuitive guidance.

Keywords

Acknowledgement

The corresponding author, W. Cha, is the inventor of the device. Pusan National University and Pusan National University Hospital hold the patents related to the device, as granted by the Korean Intellectual Property Office (KR101699229B1), the Patent Cooperation Treaty (WO2017039193A1), and United States Patent and Trademark Office (US15/536,419). Pusan National University and Pusan National University Hospital granted Solmedix Ltd. an exclusive license and the right to use.

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