한국환경보건학회지 (Journal of Environmental Health Sciences)

  • 제48권2호
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  • Pages.96-105
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  • 2022
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  • 1738-4087(pISSN)
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  • 2233-8616(eISSN)
한국환경보건학회 (Korean Society of Environmental Health)
권호 표지
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한국 성인에서 요중 3-페녹시벤조익산 농도와 자가보고 당뇨와의 연관성: 제2~3기 국민환경보건기초조사(2012~2017)

Association between Urinary 3-Phenoxybenzoic Acid Concentrations and Self-Reported Diabetes in Korean Adults: Korean National Environmental Health Survey (KoNEHS) Cycle 2~3 (2012~2017)

  • 최윤희 (고려대학교 보건과학대학 보건안전융합과학과) ;
  • 문경환 (고려대학교 4단계 BK21 러닝헬스시스템융합사업단)
  • Choi, Yun-Hee (Department of Health and Safety Convergence Science, College of Health Science, Korea University) ;
  • Moon, Kyong Whan (BK21 FOUR R&E Center for Learning Health System, Korea University)
  • 투고 : 2022.03.17
  • 심사 : 2022.04.14
  • 발행 : 2022.04.30
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초록

Background: Pyrethroid insecticides account for more than 30% of the global insecticide market and are frequently used in agricultural settings and residential and public pest control among the general population. While several animal studies have suggested that exposure to pyrethroids can alter glucose homeostasis, there is only limited evidence of the association between environmental pyrethroid exposure and diabetes in humans. Objectives: This study aimed to report environmental 3-phenoxybenzoic acid (3-PBA) concentrations in urine and evaluate its association with the risk of diabetes in Korean adults. Methods: We analyzed data from the Korean National Environmental Health Survey (KoNEHS) Cycle 2 (2012~2014) and Cycle 3 (2015~2017). A total of 10,123 participants aged ≥19 years were included. Multiple logistic regressions were used to calculate the odds ratios (ORs) for diabetes according to log-transformed urinary 3-PBA levels. We also evaluated age, sex, education, monthly income, marital status, alcohol drinking, physical activity, urinary cotinine, body mass index, and sampling season as potential effect modifiers of these associations. Results: After adjusting for all the covariates, we found significant dose-response relationships between urinary 3-PBA as quartile and the prevalence of diabetes in pooled data of KoNEHS Cycles 2 and 3. In subgroup analyses, the adverse effects of pyrethroid exposure on diabetes were significantly stronger among those aged 19~39 years (p-interaction<0.001) and those who consumed high levels of cotinine (p-interaction=0.020). Conclusions: Our findings highlight the potential diabetes risk of environmental exposure to pyrethroids and should be confirmed in large prospective studies in different populations in the future.

키워드

과제정보

본 연구는 환경부 국립환경과학원 제2기와 제3기 국민환경보건기초조사 자료를 제공받았으며(제2기: NIER-2012-00-01-944, 제3기: NIER-2017-01-01-001), 2021년 교육부의 재원으로 한국연구재단의 지원을 받아 수행되었습니다 (NRF-2021R1F1A1063967).

참고문헌

  1. Agency for Toxic Substances and Disease Registry. Public health statement for pyrethrins and pyrethroids. Available: https://wwwn.cdc.gov/TSP/PHS/PHS.aspx?phsid=785&toxid=153 [accessed 12 December 2021].
  2. Choi YH, Kang MS, Huh DA, Chae WR, Moon KW. Priority setting for management of hazardous biocides in Korea using chemical ranking and scoring method. Int J Environ Res Public Health. 2020; 17(6): 1970. https://doi.org/10.3390/ijerph17061970
  3. U.S. Environmental Protection Agency. Pyrethroids and pyrethrins. Available: https://19january2017snapshot.epa.gov/ingredients-used-pesticide-products/pyrethrins-and-pyrethroids_.html [accessed 11 August 2021].
  4. Research and Markets. Research and markets: global insecticides market (type, crop type and geography) - size, share, global trends, company profiles, analysis, segmentation and forecast, 2013 - 2020. Available: https://www.businesswire.com/news/home/20141203006466/en/Research-and-Markets-Global-Insecticides-Market-Type-Crop-Type-and-Geography---Size-Share-Global-Trends-Company-Profiles-Analysis-Segmentation-and-Forecast-2013---2020 [accessed 25 October 2021].
  5. Barr DB, Olsson AO, Wong LY, Udunka S, Baker SE, Whitehead RD, et al. Urinary concentrations of metabolites of pyrethroid insecticides in the general U.S. population: National Health and Nutrition Examination Survey 1999-2002. Environ Health Perspect. 2010; 118(6): 742-748. https://doi.org/10.1289/ehp.0901275
  6. Health Canada. Second report on human biomonitoring of environmental chemicals in Canada: results of the Canadian Health Measures Survey Cycle 2 (2009-2011). Available: https://www.canada.ca/en/health-canada/services/environmental-workplacehealth/reports-publications/environmental-contaminants/secondreport-human-biomonitoring-environmental-chemicals-canadahealth-canada-2013.html [accessed 15 September 2021].
  7. Jain RB. Variability in the levels of 3-phenoxybenzoic acid by age, gender, and race/ethnicity for the period of 2001-2002 versus 2009-2010 and its association with thyroid function among general US population. Environ Sci Pollut Res Int. 2016; 23(7): 6934-6939. https://doi.org/10.1007/s11356-015-5954-9
  8. Choi W, Kim S, Baek YW, Choi K, Lee K, Kim S, et al. Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012- 2014). Int J Hyg Environ Health. 2017; 220(2 Pt A): 29-35. https://doi.org/10.1016/j.ijheh.2016.10.002
  9. Park C, Hwang M, Kim H, Ryu S, Lee K, Choi K, et al. Early snapshot on exposure to environmental chemicals among Korean adults-results of the first Korean National Environmental Health Survey (2009-2011). Int J Hyg Environ Health. 2016; 219(4-5): 398-404. https://doi.org/10.1016/j.ijheh.2016.04.001
  10. Jung SK, Choi W, Kim SY, Hong S, Jeon HL, Joo Y, et al. Profile of environmental chemicals in the Korean population-results of the Korean National Environmental Health Survey (KoNEHS) Cycle 3, 2015-2017. Int J Environ Res Public Health. 2022; 19(2): 626. https://doi.org/10.3390/ijerph19020626
  11. Xu H, Mao Y, Xu B. Association between pyrethroid pesticide exposure and hearing loss in adolescents. Environ Res. 2020; 187: 109640. https://doi.org/10.1016/j.envres.2020.109640
  12. Ye X, Pan W, Zhao Y, Zhao S, Zhu Y, Liu W, et al. Association of pyrethroids exposure with onset of puberty in Chinese girls. Environ Pollut. 2017; 227: 606-612. https://doi.org/10.1016/j.envpol.2017.04.035
  13. Zuo L, Chen L, Chen X, Liu M, Chen H, Hao G. Pyrethroids exposure induces obesity and cardiometabolic diseases in a sex-different manner. Chemosphere. 2022; 291(Pt 2): 132935. https://doi.org/10.1016/j.chemosphere.2021.132935
  14. Hansen MR, Jors E, Lander F, Condarco G, Schlunssen V. Is cumulated pyrethroid exposure associated with prediabetes? A crosssectional study. J Agromedicine. 2014; 19(4): 417-426. https://doi.org/10.1080/1059924X.2014.945708
  15. Narendra M, Kavitha G, Helah Kiranmai A, Raghava Rao N, Varadacharyulu NC. Chronic exposure to pyrethroid-based allethrin and prallethrin mosquito repellents alters plasma biochemical profile. Chemosphere. 2008; 73: 360-364. https://doi.org/10.1016/j.chemosphere.2008.05.070
  16. Veerappan M, Hwang I, Pandurangan M. Effect of cypermethrin, carbendazim and their combination on male albino rat serum. Int J Exp Pathol. 2012; 93: 361-369. https://doi.org/10.1111/j.1365-2613.2012.00828.x
  17. Xiao X, Kim Y, Kim D, Yoon KS, Clark JM, Park Y. Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice. Food Chem Toxicol. 2017; 108(Pt A): 161-170. https://doi.org/10.1016/j.fct.2017.07.053
  18. Eraslan G, Kanbur M, Silici S, Altinordulu S, Karabacak M. Effecs of cypermethrin on some biochemical changes in rats: the protective role of propolis. Exp Anim. 2008; 57(5): 453-460. https://doi.org/10.1538/expanim.57.453
  19. Manna S, Bhattacharyya D, Mandal TK, Das S. Repeated dose toxicity of deltamethrin in rats. Indian J Pharmacol. 2005; 37(3): 160-164. https://doi.org/10.4103/0253-7613.16212
  20. Muthuviveganandavel V, Muthuraman P, Muthu S, Srikumar K. A study on low dose cypermethrin induced histopathology, lipid peroxidation and marker enzyme changes in male rat. Pestic Biochem Physiol. 2008; 91(1): 12-16. https://doi.org/10.1016/j.pestbp.2007.11.010
  21. Wang J, Zhu Y, Cai X, Yu J, Yang X, Cheng J. Abnormal glucose regulation in pyrethroid pesticide factory workers. Chemosphere. 2011; 82(7): 1080-1082. https://doi.org/10.1016/j.chemosphere.2010.10.065
  22. Leso V, Capitanelli I, Lops EA, Ricciardi W, Iavicoli I. Occupational chemical exposure and diabetes mellitus risk. Toxicol Ind Health. 2017; 33(3): 222-249. https://doi.org/10.1177/0748233715624594
  23. Park J, Park SK, Choi YH. Environmental pyrethroid exposure and diabetes in U.S. adults. Environ Res. 2019; 172: 399-407. https://doi.org/10.1016/j.envres.2018.12.043
  24. National Institute of Environmental Research. Manual for analysis of environmental pollutants in biological samples (organic chemicals). Incheon: National Institute of Environmental Research; 2006 Dec. Report No.: GOVP1200717001. 302 p.
  25. Lee I, Park YJ, Kim MJ, Kim S, Choi S, Park J, et al. Associations of urinary concentrations of phthalate metabolites, bisphenol A, and parabens with obesity and diabetes mellitus in a Korean adult population: Korean National Environmental Health Survey (KoNEHS) 2015-2017. Environ Int. 2021; 146: 106227. https://doi.org/10.1016/j.envint.2020.106227
  26. Vazquez G, Duval S, Jacobs DR Jr, Silventoinen K. Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis. Epidemiol Rev. 2007; 29: 115-128. https://doi.org/10.1093/epirev/mxm008
  27. Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2007; 298(22): 2654-2664. https://doi.org/10.1001/jama.298.22.2654
  28. Hwang MY, Ryu JM, Kwon YM, Hong SY, Park CH. Seasonal variations of exposure to environmental chemicals: implication from the Korean National Environmental Health Survey (2012-2014). J Environ Health Sci. 2018; 44(6): 572-580.
  29. Montgomery MP, Kamel F, Saldana TM, Alavanja MC, Sandler DP. Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study, 1993-2003. Am J Epidemiol. 2008; 167(10): 1235-1246. https://doi.org/10.1093/aje/kwn028
  30. Starling AP, Umbach DM, Kamel F, Long S, Sandler DP, Hoppin JA. Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study. Occup Environ Med. 2014; 71(9): 629-635. https://doi.org/10.1136/oemed-2013-101659
  31. Hocine L, Merzouk H, Merzouk SA, Ghorzi H, Youbi M, Narce M. The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns. Pestic Biochem Physiol. 2016; 134: 49-54. https://doi.org/10.1016/j.pestbp.2016.04.007
  32. Xiao X, Qi W, Clark JM, Park Y. Permethrin potentiates adipogenesis via intracellular calcium and endoplasmic reticulum stressmediated mechanisms in 3T3-L1 adipocytes. Food Chem Toxicol. 2017; 109(Pt 1): 123-129. https://doi.org/10.1016/j.fct.2017.08.049
  33. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, et al. Glucose metabolism and catecholamines. Crit Care Med. 2007; 35(9 Suppl): S508-S518. https://doi.org/10.1097/01.CCM.0000278047.06965.20
  34. Qi D, Rodrigues B. Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism. Am J Physiol Endocrinol Metab. 2007; 292(3): E654-E667. https://doi.org/10.1152/ajpendo.00453.2006
  35. de Boer SF, van der Gugten J, Slangen JL, Hijzen TH. Changes in plasma corticosterone and catecholamine contents induced by low doses of deltamethrin in rats. Toxicology. 1988; 49(2-3): 263-270. https://doi.org/10.1016/0300-483X(88)90007-8
  36. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol. 2004; 24(5): 816-823. https://doi.org/10.1161/01.ATV.0000122852.22604.78
  37. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes. 2003; 52(1): 1-8. https://doi.org/10.2337/diabetes.52.1.1
  38. Hwang M, Lee Y, Choi K, Park C. Urinary 3-phenoxybenzoic acid levels and the association with thyroid hormones in adults: Korean National Environmental Health Survey 2012-2014. Sci Total Environ. 2019; 696: 133920. https://doi.org/10.1016/j.scitotenv.2019.133920
  39. Food and Agriculture Organization of the United Nations (FAO). Food Outlook - Biannual Report on Global Food Markets. Rome: FAO; 2020. p.127.
  40. Hu P, Su W, Vinturache A, Gu H, Cai C, Lu M, et al. Urinary 3-phenoxybenzoic acid (3-PBA) concentration and pulmonary function in children: a National Health and Nutrition Examination Survey (NHANES) 2007-2012 analysis. Environ Pollut. 2021; 270: 116178. https://doi.org/10.1016/j.envpol.2020.116178
  41. Ueyama J, Hirosawa N, Mochizuki A, Kimata A, Kamijima M, Kondo T, et al. Toxicokinetics of pyrethroid metabolites in male and female rats. Environ Toxicol Pharmacol. 2010; 30(1): 88-91. https://doi.org/10.1016/j.etap.2010.03.017
  42. Tyler CR, Beresford N, van der Woning M, Sumpter JP, Tchorpe K. Metabolism and environmental degradation of pyrethroid insecticides produce compounds with endocrine activities. Environ Toxicol Chem. 2000; 19(4): 801-809. https://doi.org/10.1897/1551-5028(2000)019<0801:MAEDOP>2.3.CO;2
  43. Song G, Moreau M, Efremenko A, Lake BG, Wu H, Bruckner JV, et al. Evaluation of age-related pyrethroid pharmacokinetic differences in rats: physiologically-based pharmacokinetic model development using in vitro data and in vitro to in vivo extrapolation. Toxicol Sci. 2019; 169(2): 365-379. https://doi.org/10.1093/toxsci/kfz042
  44. Sheets LP. A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides. Neurotoxicology. 2000; 21(1-2): 57-63.
  45. Li AJ, Martinez-Moral MP, Kannan K. Temporal variability in urinary pesticide concentrations in repeated-spot and first-morningvoid samples and its association with oxidative stress in healthy individuals. Environ Int. 2019; 130: 104904. https://doi.org/10.1016/j.envint.2019.104904