Journal of Convergence for Information Technology (융합정보논문지)

Convergence Society for SMB (중소기업융합학회)
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The convergence effect of phenylephrine, isoprenaline and prazosin on vascular contractility

혈관 수축성에 대한 phenylephrine, isoprenaline 및 prazosin의 융합성 조절 효과

  • Je, Hyun Dong (Dept. of Pharmacology, College of Pharmacy, Daegu Catholic University) ;
  • Min, Young Sil (Dept. of Pharmaceutical Science, Jungwon University)
  • 제현동 (대구가톨릭대학교 약학대학) ;
  • 민영실 (중원대학교 제약공학과)
  • Received : 2022.02.14
  • Accepted : 2022.04.20
  • Published : 2022.04.28
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Abstract

In the study, we endeavored to investigate the effect of phenylephrine, isoprenaline and prazosin on the tissue-specific vascular contractility and to determine the mechanism involved. There were few reports addressing the question whether thin or thick filament modulation is included in phenylephrine, isoprenaline and prazosin-induced regulation. We hypothesized that isoprenaline and prazosin play a role in tissue-dependent regulation of vascular contractility. Denuded arterial muscles of Sprague-Dawley male rats were suspended in organ baths and isometric tensions were transduced and recorded using isometric transducers and an automatic data acquisition system. Interestingly, sustained continuous contraction of thoracic and abdominal aorta. Furthermore, isoprenaline and prazosin together with phenylephrine inhibited transiently and persistently vasoconstriction of thoracic and abdominal aorta suggesting that additional mechanisms (e.g. decreased receptor density, chemical interaction, postreceptor signaling or distribution of agonists) might be included in the modulation of vascular contractility.

심혈관계 활성이 예측되는 phenylephrine, isoprenaline, prazosin의 단독 및 병용 투여에서 혈관수축 억제능을 관찰하였고 아직 보고가 빈약한 수축성 조절 기전에 대해 조직 선택적 조절 가설을 세워서 조사하였다. 내피가 손상된 혈관을 수조내에 현수시켰고 혈관에 의한 기계적 신호가 등장력 변환기에서 전기적 신호로 변환되어 생리측정기에 표시되었다. 내피가 손상된 혈관에서 phenylephrine은 조직에 비선택적으로 지속적인 수축을 유지하였고 phenylephrine과 병용된 isoprenaline은 등척성 수축 실험에서 흉부, 복부 대동맥 등 조직에 비선택적으로 평활근에 대한 직접 작용으로 수축성을 일시적으로 감소시켰고 phenylephrine과 병용된 prazosin은 조직에 비선택적으로 평활근에 대한 직접 작용으로 수축성을 지속적으로 감소시켰다. 따라서 일부 조직에서 adrenergic beta receptor 밀도가 감소되거나 수용체 결합력이 감소되거나 수용체 결합 후 신호전달이 감소되거나 약물의 분포가 감소되어 isoprenaline이 phenylephrine의 지속적 작용에 대해 일시적으로 억제하고 prazosin이 지속적으로 억제하는 것으로 생각된다.

Keywords

Acknowledgement

This research was supported by the 2021 research year program funded by Jungwon University.

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