대한수의학회지 (Korean Journal of Veterinary Research)

  • 제62권4호
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  • Pages.29.1-29.7
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  • 2022
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지
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Serological responses and protection levels in chickens administered with Newcastle disease vaccines

  • Geumji, Seung (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Jiye, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Hyobi, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Ji-Yeon, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Yang-Ho, Jang (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Yeon-Hee, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Moon, Her (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Seong-Joon, Yi (College of Veterinary Medicine and Zoonoses Research Institute, Kyungpook National University) ;
  • Keun-Woo, Lee (College of Veterinary Medicine and Zoonoses Research Institute, Kyungpook National University) ;
  • Il, Jang (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Young Ju, Lee (College of Veterinary Medicine and Zoonoses Research Institute, Kyungpook National University)
  • 투고 : 2022.08.23
  • 심사 : 2022.10.17
  • 발행 : 2022.12.31
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초록

Vaccination against Newcastle disease (ND) is the most effective means of controlling the disease, and these vaccines are commercialized only after their safety and effectiveness have been verified through tests that comply with Korean Standards of National Lot Release for Veterinary Biologics. This study investigated whether a relatively convenient and safe serological test can be used in place of the challenge test using highly virulent ND virus. Hemagglutination inhibition (HI) assay and enzyme-linked immunosorbent assay (ELISA) were considered positive of log2 2 or more and cutoff value of 200 or more, respectively, in both live and inactivated vaccines. However, when the antibody levels of the live and inactivated vaccines induced using the Ulster 2C, KBNP-C4152R2L, and K148/08 strains were compared, the antibody titers for inactivated vaccines were significantly higher than those for live vaccines in both the HI assay and ELISA. A strong positive correlation was observed between HI and ELISA antibody titers. The live vaccines corresponded to a survival rates of ≥ 80% and the inactivated vaccines corresponded to 100% survival rates. This study confirmed that standard efficacy tests can serve as serological tests, and can replace the challenge test and that the vaccine approval process can be improved.

키워드

과제정보

This research was supported by a grant from the Animal and Plant Quarantine Agency of the Republic of Korea (no. B-1543073-2021-23-01).

참고문헌

  1. Gowthaman V, Singh SD, Dhama K, Desingu PA, Kumar A, Malik YS, Munir M. Isolation and characterization of genotype XIII Newcastle disease virus from Emu in India. Virusdisease 2016;27:315-318.  https://doi.org/10.1007/s13337-016-0324-x
  2. Sinkovics JG, Horvath JC. Newcastle disease virus (NDV): brief history of its oncolytic strains. J Clin Virol 2000;16:1-15.  https://doi.org/10.1016/S1386-6532(99)00072-4
  3. Dimitrov KM, Abolnik C, Afonso CL, Albina E, Bahl J, Berg M, Briand FX, Brown IH, Choi KS, Chvala I, Diel DG, Durr PA, Ferreira HL, Fusaro A, Gil P, Goujgoulova GV, Grund C, Hicks JT, Joannis TM, Torchetti MK, Kolosov S, Lambrecht B, Lewis NS, Liu H, Liu H, McCullough S, Miller PJ, Monne I, Muller CP, Munir M, Reischak D, Sabra M, Samal SK, Servan de Almeida R, Shittu I, Snoeck CJ, Suarez DL, Van Borm S, Wang Z, Wong FY. Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus. Infect Genet Evol 2019;74:103917.  https://doi.org/10.1016/j.meegid.2019.103917
  4. Alexander DJ. Gordon memorial lecture: Newcastle disease. Br Poult Sci 2001;42:5-22.  https://doi.org/10.1080/713655022
  5. Gogoi P, Ganar K, Kumar S. Avian paramyxovirus: a brief review. Transbound Emerg Dis 2017;64:53-67.  https://doi.org/10.1111/tbed.12355
  6. Kapczynski DR, Afonso CL, Miller PJ. Immune responses of poultry to Newcastle disease virus. Dev Comp Immunol 2013;41:447-453.  https://doi.org/10.1016/j.dci.2013.04.012
  7. Courtney SC, Susta L, Gomez D, Hines NL, Pedersen JC, Brown CC, Miller PJ, Afonso CL. Highly divergent virulent isolates of Newcastle disease virus from the Dominican Republic are members of a new genotype that may have evolved unnoticed for over 2 decades. J Clin Microbiol 2013;51:508-517.  https://doi.org/10.1128/JCM.02393-12
  8. OIE Terrestrial Manual 2021. Newcastle disease (infection with newcastle disease virus). Chapter 3.3.14. In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals [Internet]. Paris: World Organisation for Animal Health; 2021 [cited 2022 Jan 22]. Available from: https://www.woah.org/fileadmin/Home/eng/Health_standards/tahm/3.03.14_NEWCASTLE_DIS.pdf. 
  9. Mebatsion T, Koolen MJ, de Vaan LT, de Haas N, Braber M, ROmer-OberdOrfer A, van den Elzen P, van der Marel P. Newcastle disease virus (NDV) marker vaccine: an immunodominant epitope on the nucleoprotein gene of NDV can be deleted or replaced by a foreign epitope. J Virol 2002;76:10138-10146.  https://doi.org/10.1128/JVI.76.20.10138-10146.2002
  10. Alexander DJ. Newcastle disease and other avian paramyxoviruses. Rev Sci Tech 2000;19:443-462.  https://doi.org/10.20506/rst.19.2.1231
  11. Alders RG. Making Newcastle disease vaccines available at village level. Vet Rec 2014;174:502-503.  https://doi.org/10.1136/vr.g3209
  12. Dimitrov KM, Afonso CL, Yu Q, Miller PJ. Newcastle disease vaccines-a solved problem or a continuous challenge? Vet Microbiol 2017;206:126-136.  https://doi.org/10.1016/j.vetmic.2016.12.019
  13. Berhane Y, Hisanaga T, Xu W, Mosos Campos NA, Kehler H, Calderon Parra CP, Pasick J. Characterization of Colombian serotype 1 avian paramyxoviruses, 2008-2010. Virus Genes 2017;53:584-592.  https://doi.org/10.1007/s11262-017-1461-z
  14. Mayers J, Mansfield KL, Brown IH. The role of vaccination in risk mitigation and control of Newcastle disease in poultry. Vaccine 2017;35:5974-5980.  https://doi.org/10.1016/j.vaccine.2017.09.008
  15. Ministry of Agriculture, Food and Rural Affairs (MAFRA). Public notice 2019-42 [Internet]. Sejong: MAFRA; 2019 [cited 2021 Sep 9]. Available from: https://www.law.go.kr/LSW/admRulLsInfoP.do?admRulSeq= 2100000181394. 
  16. Animal and Plant Health Inspection Service, Veterinary Drugs and Biologics Division. Korean Standards of National Lot Release for Veterinary Biologics. Vol. 2. pp. 576-755, Gimcheon, 2020. 
  17. Lee YJ, Sung HW, Choi JG, Kim JH, Song CS. Molecular epidemiology of Newcastle disease viruses isolated in South Korea using sequencing of the fusion protein cleavage site region and phylogenetic relationships. Avian Pathol 2004;33:482-491.  https://doi.org/10.1080/03079450400003700
  18. Reed LJ, Muench H. A simple method of estimating fifty per cent endpoints. Am J Epidemiol 1938;27:493-497.  https://doi.org/10.1093/oxfordjournals.aje.a118408
  19. Perelman D, Goldman WF, Borkow G. Enhancement of antibody titers against Newcastle disease virus in vaccinated chicks by administration of Phyto V7. J Vaccines Vaccin 2013;4:203. 
  20. Animal and Plant Quarantine Agency. Public notice 2021-51 [Internet]. Gimcheon: Animal and Plant Quarantine Agency; 2021 [cited 2021 Sep 9]. Available from: https://law.go.kr/LSW/admRulLsInfoP.do?admRulSeq = 2100000204493#AJAX/. 
  21. Fawzy M, Ali RR, Elfeil WK, Saleh AA, El-Tarabilli MM. Efficacy of inactivated velogenic Newcastle disease virus genotype VII vaccine in broiler chickens. Vet Res Forum 2020;11:113-120. 
  22. Nagai Y, Klenk HD, Rott R. Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus. Virology 1976;72:494-508.  https://doi.org/10.1016/0042-6822(76)90178-1
  23. Ogawa R, Yanagida N, Saeki S, Saito S, Ohkawa S, Gotoh H, Kodama K, Kamogawa K, Sawaguchi K, Iritani Y. Recombinant fowlpox viruses inducing protective immunity against Newcastle disease and fowlpox viruses. Vaccine 1990;8:486-490.  https://doi.org/10.1016/0264-410X(90)90251-G
  24. Kim JN, Won H, Mo IP. Efficacy of ELISA for measurement of protective Newcastle disease antibody level in broilers. Korean J Vet Res 2006;46:185-196. 
  25. Koh WS, Lee JW, Kwak KH, Kwon JT, Song HJ. Comparison of ELISA and HI titers in broiler chicks vaccinated with infectious bronchitis virus and Newcastle disease virus. Korean J Vet Serv 2001;24:21-29. 
  26. Ge J, Liu Y, Jin L, Gao D, Bai C, Ping W. Construction of recombinant baculovirus vaccines for Newcastle disease virus and an assessment of their immunogenicity. J Biotechnol 2016;231:201-211.  https://doi.org/10.1016/j.jbiotec.2016.03.037
  27. Lee YJ, Sung HW, Choi JG, Lee EK, Yoon H, Kim JH, Song CS. Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutininneuraminidase proteins. J Vet Sci 2008;9:301-308.  https://doi.org/10.4142/jvs.2008.9.3.301
  28. Thayer SG, Villegas P, Fletcher OJ. Comparison of two commercial enzyme-linked immunosorbent assays and conventional methods for avian serology. Avian Dis 1987;31:120-124.  https://doi.org/10.2307/1590783
  29. Jeurissen SH, Boonstra-Blom AG, Al-Garib SO, Hartog L, Koch G. Defence mechanisms against viral infection in poultry: a review. Vet Q 2000;22:204-208.  https://doi.org/10.1080/01652176.2000.9695059
  30. Al-Garib SO, Gielkens AL, Gruys DE, Hartog L, Koch G. Immunoglobulin class distribution of systemic and mucosal antibody responses to Newcastle disease in chickens. Avian Dis 2003;47:32-40.  https://doi.org/10.1637/0005-2086(2003)047[0032:ICDOSA]2.0.CO;2
  31. Chansiripornchai N, Sasipreeyajan J. Efficacy of live B1 or Ulster 2C Newcastle disease vaccines simultaneously vaccinated with inactivated oil adjuvant vaccine for protection of Newcastle disease virus in broiler chickens. Acta Vet Scand 2006;48:2.  https://doi.org/10.1186/1751-0147-48-2
  32. Brown J, Resurreccion RS, Dickson TG. The relationship between the hemagglutination-inhibition test and the enzyme-linked immunosorbent assay for the detection of antibody to Newcastle disease. Avian Dis 1990;34:585-587.  https://doi.org/10.2307/1591248
  33. Marquardt WW, Snyder DB, Savage PK, Kadavil SK, Yancey FS. Antibody response to Newcastle disease virus given by two different routes as measured by ELISA and hemagglutination-inhibition test and associated tracheal immunity. Avian Dis 1985;29:71-79.  https://doi.org/10.2307/1590695
  34. Adair BM, McNulty MS, Todd D, Connor TJ, Burns K. Quantitative estimation of Newcastle disease virus antibody levels in chickens and turkeys by ELISA. Avian Pathol 1989;18:175-192.  https://doi.org/10.1080/03079458908418589
  35. Kapczynski DR, King DJ. Protection of chickens against overt clinical disease and determination of viral shedding following vaccination with commercially available Newcastle disease virus vaccines upon challenge with highly virulent virus from the California 2002 exotic Newcastle disease outbreak. Vaccine 2005;23:3424-3433.  https://doi.org/10.1016/j.vaccine.2005.01.140
  36. Wilson RA, Perrotta C, Frey B, Eckroade RJ. An enzymelinked immunosorbent assay that measures protective antibody levels to Newcastle disease virus in chickens. Avian Dis 1984;28:1079-1085. https://doi.org/10.2307/1590283