Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Serological responses and protection levels in chickens administered with Newcastle disease vaccines

  • Geumji, Seung (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Jiye, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Hyobi, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Ji-Yeon, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Yang-Ho, Jang (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Yeon-Hee, Kim (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Moon, Her (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Seong-Joon, Yi (College of Veterinary Medicine and Zoonoses Research Institute, Kyungpook National University) ;
  • Keun-Woo, Lee (College of Veterinary Medicine and Zoonoses Research Institute, Kyungpook National University) ;
  • Il, Jang (Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA)) ;
  • Young Ju, Lee (College of Veterinary Medicine and Zoonoses Research Institute, Kyungpook National University)
  • Received : 2022.08.23
  • Accepted : 2022.10.17
  • Published : 2022.12.31
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Abstract

Vaccination against Newcastle disease (ND) is the most effective means of controlling the disease, and these vaccines are commercialized only after their safety and effectiveness have been verified through tests that comply with Korean Standards of National Lot Release for Veterinary Biologics. This study investigated whether a relatively convenient and safe serological test can be used in place of the challenge test using highly virulent ND virus. Hemagglutination inhibition (HI) assay and enzyme-linked immunosorbent assay (ELISA) were considered positive of log2 2 or more and cutoff value of 200 or more, respectively, in both live and inactivated vaccines. However, when the antibody levels of the live and inactivated vaccines induced using the Ulster 2C, KBNP-C4152R2L, and K148/08 strains were compared, the antibody titers for inactivated vaccines were significantly higher than those for live vaccines in both the HI assay and ELISA. A strong positive correlation was observed between HI and ELISA antibody titers. The live vaccines corresponded to a survival rates of ≥ 80% and the inactivated vaccines corresponded to 100% survival rates. This study confirmed that standard efficacy tests can serve as serological tests, and can replace the challenge test and that the vaccine approval process can be improved.

Keywords

Acknowledgement

This research was supported by a grant from the Animal and Plant Quarantine Agency of the Republic of Korea (no. B-1543073-2021-23-01).

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